Team hope/good trouble/go high💙
https://www.hopkinsmedicine.org/profiles/details/tanya-prowell
NEW RPCT: 5, 10, or 15d of Paxlovid in 156 immunocompromised (IC) outpatients w/ #COVID19. No diff in sustained viral suppression d15-44.
🔑 takeaways: Rebound isn’t rare (1 in 4 of severely IC), & enrichment/endpoint selection matter.
www.sciencedirect.com/science/arti...
NEW RPCT: 5, 10, or 15d of Paxlovid in 156 immunocompromised (IC) outpatients w/ #COVID19. No diff in sustained viral suppression d15-44.
🔑 takeaways: Rebound isn’t rare (1 in 4 of severely IC), & enrichment/endpoint selection matter.
www.sciencedirect.com/science/arti...
Prosp cohorts (China, N=74K):
At 8-10 yrs, EBV VCA-IgA was assoc w/:
Overall cancer risk ⬆️ 5x
Lung cancer 1.8x
Liver cancer 1.7x
Nasopharyngeal cancer 26x Lymphoma 3.2x
Dose-response +.
🔑 We need ways to prevent/treat mono.
#DrugDevelopment
www.nature.com/articles/s41...
Prosp cohorts (China, N=74K):
At 8-10 yrs, EBV VCA-IgA was assoc w/:
Overall cancer risk ⬆️ 5x
Lung cancer 1.8x
Liver cancer 1.7x
Nasopharyngeal cancer 26x Lymphoma 3.2x
Dose-response +.
🔑 We need ways to prevent/treat mono.
#DrugDevelopment
www.nature.com/articles/s41...
📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need.
www.thelancet.com/action/showP...
📢 Prospective cohort study (CO-FLOW) of adults hospitalized for #COVID19 finds only 1 in 8 fully recovered at 3m, & only 1 in 4 at 3y. More than half had ⬇️ memory & concentration at 3y. This is #LongCovid. HUGE unmet #DrugDevelopment need.
www.thelancet.com/action/showP...
NEW study of outpatients w/ #COVID19 + self-reported #BrainFog after infection vs healthy controls finds marked hypometabolism on PET & brain wave changes on EEG corresponding to areas responsible for attention, memory, language, & decision-making. www.nature.com/articles/s41...
NEW study of outpatients w/ #COVID19 + self-reported #BrainFog after infection vs healthy controls finds marked hypometabolism on PET & brain wave changes on EEG corresponding to areas responsible for attention, memory, language, & decision-making. www.nature.com/articles/s41...
👉 9/25/25: in person (ASCO HQ, in DC area)
or
👉 1/29/26: virtual
See you there! #MedSky #OncSky #MedEd
👉 9/25/25: in person (ASCO HQ, in DC area)
or
👉 1/29/26: virtual
See you there! #MedSky #OncSky #MedEd
ascopubs.org/toc/edbk/cur...
#OncoAlert
ascopubs.org/toc/edbk/cur...
#OncoAlert
Invasive cardiopulm exercise testing (iCPET) at Brigham & Women’s finds people w/ #MECFS & #longCovid have symptomatic ⬇️ aerobic capacity at peak exercise due to preload insufficiency & impaired systemic O2 extraction, latter c/w peripheral L➡️R shunt &/or limb skel muscle dysfunction. /1
Invasive cardiopulm exercise testing (iCPET) at Brigham & Women’s finds people w/ #MECFS & #longCovid have symptomatic ⬇️ aerobic capacity at peak exercise due to preload insufficiency & impaired systemic O2 extraction, latter c/w peripheral L➡️R shunt &/or limb skel muscle dysfunction. /1
The # of Americans with new disability has increased sharply in the #pandemic. The # who report a cognitive disability specifically has grown by 43% since 2019. #COVID19 #LongCovid
www.nytimes.com/interactive/...
The # of Americans with new disability has increased sharply in the #pandemic. The # who report a cognitive disability specifically has grown by 43% since 2019. #COVID19 #LongCovid
www.nytimes.com/interactive/...
📢The 2024 @health.nationalacademies.org Long COVID Definition: What Clinicians Need to Know.
If you provide patient care, in any specialty, this 3 pg paper is must read. You are seeing people w/ #longCovid, whether you realize it yet or not.
link.springer.com/content/pdf/...
📢The 2024 @health.nationalacademies.org Long COVID Definition: What Clinicians Need to Know.
If you provide patient care, in any specialty, this 3 pg paper is must read. You are seeing people w/ #longCovid, whether you realize it yet or not.
link.springer.com/content/pdf/...
#BlackWomenInMedicine #LatinasInMedicine #LGBTQ #MedSky
#BlackWomenInMedicine #LatinasInMedicine #LGBTQ #MedSky
A randomized, double-blind, placebo-cont trial (N=50) of plasma exchange (2x/wk x 3w) vs sham (saline) in people with mod-severe #LongCovid found no benefit in any efficacy endpoint. Grateful for RCTs & for quality journals publishing them even if neg. www.nature.com/articles/s41...
A randomized, double-blind, placebo-cont trial (N=50) of plasma exchange (2x/wk x 3w) vs sham (saline) in people with mod-severe #LongCovid found no benefit in any efficacy endpoint. Grateful for RCTs & for quality journals publishing them even if neg. www.nature.com/articles/s41...
Clinicians, YOU are the most trusted source of info on #vaccines for your patients. Regardless of your specialty, take a moment to check if they are up to date on immunizations & inform them that #VaccinesWork.
Clinicians, YOU are the most trusted source of info on #vaccines for your patients. Regardless of your specialty, take a moment to check if they are up to date on immunizations & inform them that #VaccinesWork.
Based on 🇺🇸 wastewater monitoring, #COVID19, #flu A, & #RSV (which cause similar symptoms) & #norovirus (which causes vomiting & diarrhea) are 🚀 nationwide. Other infections are low.
There are antiviral meds to treat Covid & flu, so get tested/seek care if sick!
wastewaterscan.org
Based on 🇺🇸 wastewater monitoring, #COVID19, #flu A, & #RSV (which cause similar symptoms) & #norovirus (which causes vomiting & diarrhea) are 🚀 nationwide. Other infections are low.
There are antiviral meds to treat Covid & flu, so get tested/seek care if sick!
wastewaterscan.org
IMPORTANT
I’ve been thinking a lot today about the crisis of 🇺🇸 illiteracy. More than half of US adults read below 6th grade level, & 1 in 5 can’t read at all. The harms of illiteracy to us ALL are astounding (see 📸). If you can read this, you can help fix this. /1
IMPORTANT
I’ve been thinking a lot today about the crisis of 🇺🇸 illiteracy. More than half of US adults read below 6th grade level, & 1 in 5 can’t read at all. The harms of illiteracy to us ALL are astounding (see 📸). If you can read this, you can help fix this. /1
#MedSky #HCWvsHunger #tariffs
#MedSky #HCWvsHunger #tariffs
You can contact your elected officials in Congress even if you don’t know who they are. Call the Congressional switchboard (📸 below), & they will connect to the right Rep/Senators based on your address. You can also find them online here: www.congress.gov/members/find...
You can contact your elected officials in Congress even if you don’t know who they are. Call the Congressional switchboard (📸 below), & they will connect to the right Rep/Senators based on your address. You can also find them online here: www.congress.gov/members/find...
Looks like EMA changed their handle, so I just deleted my post & reposted with their new handle: @ema.europa.eu.
Looks like EMA changed their handle, so I just deleted my post & reposted with their new handle: @ema.europa.eu.
Go to the non-partisan vote.org to register to vote or confirm you are registered & sign up for election reminders. Those <18 can pledge to register to vote at 18.
Go to the non-partisan vote.org to register to vote or confirm you are registered & sign up for election reminders. Those <18 can pledge to register to vote at 18.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
NEW Retrospective cohort study (N=225K, kids to 21y >3/4 not vaccinated) from NIH RECOVER characterizes diffs in #longCOVID symptoms by race after severe & non-severe #COVID19 illness.
#PedSky, may help direct your ROS (eg, #POTS in Asian pts).
www.nature.com/articles/s41...
NEW Retrospective cohort study (N=225K, kids to 21y >3/4 not vaccinated) from NIH RECOVER characterizes diffs in #longCOVID symptoms by race after severe & non-severe #COVID19 illness.
#PedSky, may help direct your ROS (eg, #POTS in Asian pts).
www.nature.com/articles/s41...
A syst review of 31 #LongCovid studies finds exec dysfunction (nonverbal reasoning, language, & recall deficits) are common even after “mild” #COVID19 & correlated w/ changes in frontal & cerebellar regions of brain. Many symptoms mimic #ADHD.
www.cell.com/action/showP...
A syst review of 31 #LongCovid studies finds exec dysfunction (nonverbal reasoning, language, & recall deficits) are common even after “mild” #COVID19 & correlated w/ changes in frontal & cerebellar regions of brain. Many symptoms mimic #ADHD.
www.cell.com/action/showP...
#Norovirus infections, which cause severe vomiting/diarrhea, are continuing to 🚀. See 🧵 for what you need to know. A key point is that this virus is so contagious & you MUST #WashYourHands w/ soap & water. Hand sanitizer is not effective vs norovirus.
www.science.org/content/arti...
#Norovirus infections, which cause severe vomiting/diarrhea, are continuing to 🚀. See 🧵 for what you need to know. A key point is that this virus is so contagious & you MUST #WashYourHands w/ soap & water. Hand sanitizer is not effective vs norovirus.
www.science.org/content/arti...