Thomas Andrillon
@thomasandrillon.bsky.social
Studying the stream of consciousness during sleep and wakefulness
Neuroscientist at the Paris Brain Institute
Chargé de Recherche Inserm
Adjunct Senior Research Fellow at Monash University
Co-Editor-in-Chief of Neuroscience of Consciousness (OUP)
Neuroscientist at the Paris Brain Institute
Chargé de Recherche Inserm
Adjunct Senior Research Fellow at Monash University
Co-Editor-in-Chief of Neuroscience of Consciousness (OUP)
Is #ketamine a good pharmacological model of #schyzophrenia?
W/ @lucieberko.bsky.social, @standehaene.bsky.social, R Gaillard, and A Salvador, we investigated the impact of ketamine on conscious processing and attention in healthy subjects.
Check the preprint!
www.biorxiv.org/content/10.1...
🧠🧪
W/ @lucieberko.bsky.social, @standehaene.bsky.social, R Gaillard, and A Salvador, we investigated the impact of ketamine on conscious processing and attention in healthy subjects.
Check the preprint!
www.biorxiv.org/content/10.1...
🧠🧪
November 13, 2025 at 1:03 PM
Is #ketamine a good pharmacological model of #schyzophrenia?
W/ @lucieberko.bsky.social, @standehaene.bsky.social, R Gaillard, and A Salvador, we investigated the impact of ketamine on conscious processing and attention in healthy subjects.
Check the preprint!
www.biorxiv.org/content/10.1...
🧠🧪
W/ @lucieberko.bsky.social, @standehaene.bsky.social, R Gaillard, and A Salvador, we investigated the impact of ketamine on conscious processing and attention in healthy subjects.
Check the preprint!
www.biorxiv.org/content/10.1...
🧠🧪
A high NRD was predictive of mortality, which suggests that NRD helps patients to cope with breathing disturbances, but it might induce long-term adverse effects (e.g., perturbation of sleep), impacting survival!
September 10, 2025 at 2:31 PM
A high NRD was predictive of mortality, which suggests that NRD helps patients to cope with breathing disturbances, but it might induce long-term adverse effects (e.g., perturbation of sleep), impacting survival!
Key findings:
➡️ NRD is present only in COPD patients
➡️ NRD drops during all sleep stages compared to wake
➡️ NRD is lowest in deep sleep (N3) and REM
➡️ Patients with better sleep quality show larger NRD decreases at night
➡️ NRD is present only in COPD patients
➡️ NRD drops during all sleep stages compared to wake
➡️ NRD is lowest in deep sleep (N3) and REM
➡️ Patients with better sleep quality show larger NRD decreases at night
September 10, 2025 at 2:31 PM
Key findings:
➡️ NRD is present only in COPD patients
➡️ NRD drops during all sleep stages compared to wake
➡️ NRD is lowest in deep sleep (N3) and REM
➡️ Patients with better sleep quality show larger NRD decreases at night
➡️ NRD is present only in COPD patients
➡️ NRD drops during all sleep stages compared to wake
➡️ NRD is lowest in deep sleep (N3) and REM
➡️ Patients with better sleep quality show larger NRD decreases at night
We propose here a semi-automated analysis pipeline to analyse long (whole-night) EMG recordings.
We measured respiratory muscle activity during polysomnography (sleep) in COPD patients and used an automated approach to extract NRD from thousands of breaths without manual scoring.
We measured respiratory muscle activity during polysomnography (sleep) in COPD patients and used an automated approach to extract NRD from thousands of breaths without manual scoring.
September 10, 2025 at 2:31 PM
We propose here a semi-automated analysis pipeline to analyse long (whole-night) EMG recordings.
We measured respiratory muscle activity during polysomnography (sleep) in COPD patients and used an automated approach to extract NRD from thousands of breaths without manual scoring.
We measured respiratory muscle activity during polysomnography (sleep) in COPD patients and used an automated approach to extract NRD from thousands of breaths without manual scoring.
We discuss how metrics of consciousness (contents or states) could be integrated to better account for consciousness and its dynamics.
September 4, 2025 at 3:18 PM
We discuss how metrics of consciousness (contents or states) could be integrated to better account for consciousness and its dynamics.
We try to bridge the two main approaches of conscious studies: the state (being conscious) and content (being conscious of) approach by examining how both states and contents evolve within and across wakefulness and sleep.
September 4, 2025 at 3:18 PM
We try to bridge the two main approaches of conscious studies: the state (being conscious) and content (being conscious of) approach by examining how both states and contents evolve within and across wakefulness and sleep.
🧠 New preprint! 🧠
As part of a forthcoming book on consciousness, we wrote a chapter on:
Spontaneous thoughts and experiences across wakefulness and sleep
osf.io/preprints/ps...
with @parboulakis.bsky.social @ademertzi.bsky.social and @jdsitt.bsky.social
A brief 🧵!
As part of a forthcoming book on consciousness, we wrote a chapter on:
Spontaneous thoughts and experiences across wakefulness and sleep
osf.io/preprints/ps...
with @parboulakis.bsky.social @ademertzi.bsky.social and @jdsitt.bsky.social
A brief 🧵!
September 4, 2025 at 3:18 PM
🧠 New preprint! 🧠
As part of a forthcoming book on consciousness, we wrote a chapter on:
Spontaneous thoughts and experiences across wakefulness and sleep
osf.io/preprints/ps...
with @parboulakis.bsky.social @ademertzi.bsky.social and @jdsitt.bsky.social
A brief 🧵!
As part of a forthcoming book on consciousness, we wrote a chapter on:
Spontaneous thoughts and experiences across wakefulness and sleep
osf.io/preprints/ps...
with @parboulakis.bsky.social @ademertzi.bsky.social and @jdsitt.bsky.social
A brief 🧵!
Using top-down (spectral) or bottom-up (catch-22, @bendfulcher.bsky.social) feature extraction, we show we can decode dream occurrence in both NREM and REM sleep.
This idea here was not to get the perfect classifier but to show that the Dream database could help *you* build the next Dreamcatcher!
This idea here was not to get the perfect classifier but to show that the Dream database could help *you* build the next Dreamcatcher!
August 14, 2025 at 1:40 PM
Using top-down (spectral) or bottom-up (catch-22, @bendfulcher.bsky.social) feature extraction, we show we can decode dream occurrence in both NREM and REM sleep.
This idea here was not to get the perfect classifier but to show that the Dream database could help *you* build the next Dreamcatcher!
This idea here was not to get the perfect classifier but to show that the Dream database could help *you* build the next Dreamcatcher!
Using automated sleep scoring algorithms, we show that dream occurrence in NREM is associated with an increase in the probability of wakefulness within NREM (i.e., the signal looks a bit more like wake).
August 14, 2025 at 1:40 PM
Using automated sleep scoring algorithms, we show that dream occurrence in NREM is associated with an increase in the probability of wakefulness within NREM (i.e., the signal looks a bit more like wake).
William Wong and Rubén Herzog (@rherzoga.bsky.social) performed analyses to showcase the database's potential (we scratched only the surface!).
We confirm dreams are pervasive during sleep and not at all restricted to REM sleep!
[E: experience/dreaming; EWR: E without recall; NE: no experience]
We confirm dreams are pervasive during sleep and not at all restricted to REM sleep!
[E: experience/dreaming; EWR: E without recall; NE: no experience]
August 14, 2025 at 1:40 PM
William Wong and Rubén Herzog (@rherzoga.bsky.social) performed analyses to showcase the database's potential (we scratched only the surface!).
We confirm dreams are pervasive during sleep and not at all restricted to REM sleep!
[E: experience/dreaming; EWR: E without recall; NE: no experience]
We confirm dreams are pervasive during sleep and not at all restricted to REM sleep!
[E: experience/dreaming; EWR: E without recall; NE: no experience]
This paper was first the opportunity to clarify the concept of dreaming in science.
We propose a common definition and a consensus methodology to study dreams with a neuroscientific approach!
We propose a common definition and a consensus methodology to study dreams with a neuroscientific approach!
August 14, 2025 at 1:40 PM
This paper was first the opportunity to clarify the concept of dreaming in science.
We propose a common definition and a consensus methodology to study dreams with a neuroscientific approach!
We propose a common definition and a consensus methodology to study dreams with a neuroscientific approach!
💤🧠🧪 New article! 🧪🧠💤
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
August 14, 2025 at 1:40 PM
💤🧠🧪 New article! 🧪🧠💤
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
But nope...
So excited about the upcoming ChatGPT-6 though!
So excited about the upcoming ChatGPT-6 though!
August 8, 2025 at 3:28 PM
But nope...
So excited about the upcoming ChatGPT-6 though!
So excited about the upcoming ChatGPT-6 though!
We were so close!
August 8, 2025 at 3:28 PM
We were so close!
Does SW density explain the link between ADHD and behaviour?
We ran mediation analyses to figure this out!
➡️ SW density mediated ADHD-related increases in omission errors, RT variability, sleepiness, etc...
More than a biomarker, sleep intrusions could represent a mechanism of lapses in ADHD!
We ran mediation analyses to figure this out!
➡️ SW density mediated ADHD-related increases in omission errors, RT variability, sleepiness, etc...
More than a biomarker, sleep intrusions could represent a mechanism of lapses in ADHD!
August 1, 2025 at 7:25 AM
Does SW density explain the link between ADHD and behaviour?
We ran mediation analyses to figure this out!
➡️ SW density mediated ADHD-related increases in omission errors, RT variability, sleepiness, etc...
More than a biomarker, sleep intrusions could represent a mechanism of lapses in ADHD!
We ran mediation analyses to figure this out!
➡️ SW density mediated ADHD-related increases in omission errors, RT variability, sleepiness, etc...
More than a biomarker, sleep intrusions could represent a mechanism of lapses in ADHD!
These slow waves correlated with behaviour and subjective experience:
– ⬇️ with RT
– ⬆️ with RT variability
– ⬆️ with omissions
- ⬆️ with sleepiness
– ⬇️ with RT
– ⬆️ with RT variability
– ⬆️ with omissions
- ⬆️ with sleepiness
August 1, 2025 at 7:25 AM
These slow waves correlated with behaviour and subjective experience:
– ⬇️ with RT
– ⬆️ with RT variability
– ⬆️ with omissions
- ⬆️ with sleepiness
– ⬇️ with RT
– ⬆️ with RT variability
– ⬆️ with omissions
- ⬆️ with sleepiness
We turned our attention to the #EEG and signs of sleep intrusions.
In line with our hypotheses, ADHD individuals showed more sleep-like slow waves, especially over parietal & temporal regions.
In line with our hypotheses, ADHD individuals showed more sleep-like slow waves, especially over parietal & temporal regions.
August 1, 2025 at 7:25 AM
We turned our attention to the #EEG and signs of sleep intrusions.
In line with our hypotheses, ADHD individuals showed more sleep-like slow waves, especially over parietal & temporal regions.
In line with our hypotheses, ADHD individuals showed more sleep-like slow waves, especially over parietal & temporal regions.
ADHD also reported:
- ⬆️ mind-wandering
- ⬆️ mind-blanking
- ⬆️ sleepiness
These changes were associated with poorer performance, and MW was less intentional than in non-ADHD!
What is driving these behavioural and experiential changes? 🤔
- ⬆️ mind-wandering
- ⬆️ mind-blanking
- ⬆️ sleepiness
These changes were associated with poorer performance, and MW was less intentional than in non-ADHD!
What is driving these behavioural and experiential changes? 🤔
August 1, 2025 at 7:25 AM
ADHD also reported:
- ⬆️ mind-wandering
- ⬆️ mind-blanking
- ⬆️ sleepiness
These changes were associated with poorer performance, and MW was less intentional than in non-ADHD!
What is driving these behavioural and experiential changes? 🤔
- ⬆️ mind-wandering
- ⬆️ mind-blanking
- ⬆️ sleepiness
These changes were associated with poorer performance, and MW was less intentional than in non-ADHD!
What is driving these behavioural and experiential changes? 🤔
Behaviourally, in ADHD participants, we observed:
- ⬆️ commission errors (false alarms)
- ⬆️ reaction times variability
A typical pattern in a task challenging sustained attention and response inhibition.
- ⬆️ commission errors (false alarms)
- ⬆️ reaction times variability
A typical pattern in a task challenging sustained attention and response inhibition.
August 1, 2025 at 7:25 AM
Behaviourally, in ADHD participants, we observed:
- ⬆️ commission errors (false alarms)
- ⬆️ reaction times variability
A typical pattern in a task challenging sustained attention and response inhibition.
- ⬆️ commission errors (false alarms)
- ⬆️ reaction times variability
A typical pattern in a task challenging sustained attention and response inhibition.
We recorded EEG while adults with (n=32) and without ADHD (n=31) performed a sustained attention task.
We probed moment-to-moment changes in mental state (on-task, mind-wandering, mind-blanking).
We detected EEG signs of sleep intrusions with sleep-like slow waves (SWs).
We probed moment-to-moment changes in mental state (on-task, mind-wandering, mind-blanking).
We detected EEG signs of sleep intrusions with sleep-like slow waves (SWs).
August 1, 2025 at 7:25 AM
We recorded EEG while adults with (n=32) and without ADHD (n=31) performed a sustained attention task.
We probed moment-to-moment changes in mental state (on-task, mind-wandering, mind-blanking).
We detected EEG signs of sleep intrusions with sleep-like slow waves (SWs).
We probed moment-to-moment changes in mental state (on-task, mind-wandering, mind-blanking).
We detected EEG signs of sleep intrusions with sleep-like slow waves (SWs).
🧠🧪💤 New preprint!
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
We show that intrusions of sleep-like activity during wake help explain attention lapses in ADHD.
🔗 www.biorxiv.org/content/10.1...
#ADHD #Sleep #Neuro
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
We show that intrusions of sleep-like activity during wake help explain attention lapses in ADHD.
🔗 www.biorxiv.org/content/10.1...
#ADHD #Sleep #Neuro
August 1, 2025 at 7:25 AM
🧠🧪💤 New preprint!
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
We show that intrusions of sleep-like activity during wake help explain attention lapses in ADHD.
🔗 www.biorxiv.org/content/10.1...
#ADHD #Sleep #Neuro
Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD
We show that intrusions of sleep-like activity during wake help explain attention lapses in ADHD.
🔗 www.biorxiv.org/content/10.1...
#ADHD #Sleep #Neuro
Getting articles in peer-reviewed journals is like going on a bear hunt!
We can't go over it,
We can't go under it,
We've got to go through it!
We can't go over it,
We can't go under it,
We've got to go through it!
July 31, 2025 at 6:46 AM
Getting articles in peer-reviewed journals is like going on a bear hunt!
We can't go over it,
We can't go under it,
We've got to go through it!
We can't go over it,
We can't go under it,
We've got to go through it!
We need your help!!! 🧠🧪💤
If you are human, you fall asleep at least once a day! What happens in your mind then?
Scientists know actually very little about this private moment.
We propose a 20-min survey to get as much data as possible!
Here is the link:
redcap.link/DriftingMinds
If you are human, you fall asleep at least once a day! What happens in your mind then?
Scientists know actually very little about this private moment.
We propose a 20-min survey to get as much data as possible!
Here is the link:
redcap.link/DriftingMinds
June 19, 2025 at 2:43 PM
We need your help!!! 🧠🧪💤
If you are human, you fall asleep at least once a day! What happens in your mind then?
Scientists know actually very little about this private moment.
We propose a 20-min survey to get as much data as possible!
Here is the link:
redcap.link/DriftingMinds
If you are human, you fall asleep at least once a day! What happens in your mind then?
Scientists know actually very little about this private moment.
We propose a 20-min survey to get as much data as possible!
Here is the link:
redcap.link/DriftingMinds
My feeling is that some researchers had the wrong expectation regarding adversarial collaborations.
I don't think they were designed to confront once and for all two theories against each other, and just these two at the exclusion of all others.
I don't think they were designed to confront once and for all two theories against each other, and just these two at the exclusion of all others.
May 1, 2025 at 7:42 AM
My feeling is that some researchers had the wrong expectation regarding adversarial collaborations.
I don't think they were designed to confront once and for all two theories against each other, and just these two at the exclusion of all others.
I don't think they were designed to confront once and for all two theories against each other, and just these two at the exclusion of all others.