The American Society for Clinical Investigation
@the-asci.org
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry.
https://the-asci.org
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https://the-asci.org
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ASCI member Craig M. Horbinski just published @insight.jci.org
IDH inhibitors can delay high-grade, IDH-mutant gliomas, but then fall short.
Craig M. Horbinski & team now show the epigenetic changes that characterize IDH mutant gliomas suppress YAP & TAZ, rendering the tumors sensitive to HDAC inhibitors: insight.jci.org/articles/vie...
Craig M. Horbinski & team now show the epigenetic changes that characterize IDH mutant gliomas suppress YAP & TAZ, rendering the tumors sensitive to HDAC inhibitors: insight.jci.org/articles/vie...
November 26, 2025 at 3:11 PM
ASCI member Craig M. Horbinski just published @insight.jci.org
Reposted by The American Society for Clinical Investigation
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
November 25, 2025 at 2:02 PM
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
New research from ASCI member Dean Sheppard & team 👇
The strategic use of multiple models clarifies a longstanding controversy in pulmonary fibrosis
Dean Sheppard & team establish fibroblast proliferation as an important driver (and potential target) in pulmonary fibrosis: www.jci.org/articles/vie...
Dean Sheppard & team establish fibroblast proliferation as an important driver (and potential target) in pulmonary fibrosis: www.jci.org/articles/vie...
November 25, 2025 at 3:27 PM
New research from ASCI member Dean Sheppard & team 👇
New research by ASCI member Benjamin E. Gewurz @bgewurz.bsky.social
What drives pathogenic B-cell activation in autoimmunity & certain cancers?
@bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...
@bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...
November 24, 2025 at 4:19 PM
New research by ASCI member Benjamin E. Gewurz @bgewurz.bsky.social
From ASCI member Arturo Casadevall @acasadevall1.bsky.social
Fungal vaccines: so needed, so feasible, and yet so far off: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
November 21, 2025 at 6:14 PM
From ASCI member Arturo Casadevall @acasadevall1.bsky.social
New publication from ASCI member Robert Thimme @insight.jci.org
Vaccine responses in PLWH with incomplete immune recovery
Robert Thimme & team report low CD4 counts limit vaccine-induced virus-specific CD8 T cell immunity in HIV-infected immunological non-responders & highlight boosters for enhancing responses: insight.jci.org/articles/vie...
Robert Thimme & team report low CD4 counts limit vaccine-induced virus-specific CD8 T cell immunity in HIV-infected immunological non-responders & highlight boosters for enhancing responses: insight.jci.org/articles/vie...
November 21, 2025 at 1:15 PM
New publication from ASCI member Robert Thimme @insight.jci.org
Out now by ASCI member Benjamin D. Singer & team!
Can in vitro–induced regulatory T cells promote lung recovery?
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
November 20, 2025 at 3:03 PM
Out now by ASCI member Benjamin D. Singer & team!
New research from ASCI member Charles R. Langelier:
Predicting outcomes at an early stage of severe COVID-19…
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
Charles R. Langelier & team find the OLAH gene or a three-gene peripheral blood signature that accurately predicts COVID-19 mortality early in hospitalization, including in vaccinated patients: insight.jci.org/articles/vie...
November 17, 2025 at 4:06 PM
New research from ASCI member Charles R. Langelier:
A promising therapeutic approach for glioblastoma
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
November 14, 2025 at 5:05 PM
A promising therapeutic approach for glioblastoma
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
ASCI member Markus D. Siegelin & team detail a strategy targeting CDK12 in mouse models that prolongs survival and eliminates tumors in combination with standard treatment.
insight.jci.org/articles/vie...
New insights into lipid redistribution!
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
November 14, 2025 at 12:16 AM
New insights into lipid redistribution!
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
ASCI member Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease.
www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
A Research Letter by ASCI member Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
November 13, 2025 at 8:30 PM
A Research Letter by ASCI member Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
November 13, 2025 at 5:08 PM
Excessive aldosterone production can lead to cardiovascular problems, but therapeutic limitations remain
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
ASCI member David T. Breault & team show abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia & aldosterone production: insight.jci.org/articles/vie...
Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
November 12, 2025 at 5:05 PM
Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
ASCI member Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms.
www.jci.org/articles/vie...
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
November 11, 2025 at 5:05 PM
Spinal & bulbar muscular atrophy is a degenerative disorder of the neuromuscular system with no cure
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
ASCI member Andrew P. Lieberman & team find AR-targeted ASOs rescue disease in SBMA mice, showing unanticipated benefits on the spinal cord transcriptional landscape: 10.1172/JCI182955
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
November 10, 2025 at 5:07 PM
Osteoarthritis is the most common joint disease, but there are no approved disease-modifying treatments
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
ASCI member Martin K. Lotz & team discover histamine H1 receptor inverse agonists improve structure & pain in osteoarthritis mice: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
November 7, 2025 at 7:30 PM
Alveolar macrophage-fibroblast crosstalk includes a feedforward arginase 1/IL-6 circuit implicated in pulmonary fibrosis: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
G.R. Scott Budinger provides an Editor’s Note on Preeti Yadav: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
November 7, 2025 at 2:03 PM
Commentary: Neutrophils take center stage in VEXAS syndrome pathogenesis
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Ajay Tambralli & Jason S. Knight provide an editorial on Ge Dong et al.: www.jci.org/articles/vie...
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 6, 2025 at 5:07 PM
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, ASCI member Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
What's basic research? The "useless" science that changes everything.
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
November 3, 2025 at 6:07 PM
What's basic research? The "useless" science that changes everything.
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
Federal funding helps researchers take the long view that companies can't. That's how breakthrough treatments are born.
#SaveOurCures #FundNIH
New research by ASCI member Marc E. Rothenberg 👇
Rothenberg & team discover allergen-specific mRNA-lipid nanoparticle therapy modulates immune responses, reducing allergy symptoms while enhancing protection in mice: www.jci.org/articles/vie...
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
@jilianmelamed.bsky.social @drewweissmanlab.bsky.social @cincykidsallergyim.bsky.social
November 4, 2025 at 4:45 PM
New research by ASCI member Marc E. Rothenberg 👇
Out now by ASCI member Daniel Drucker @danieljdrucker.bsky.social
Anti-inflammatory actions of glucagon-like peptide 1 medicines beyond metabolic benefits
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
Chi Kin Wong & Daniel J. Drucker provide a Review for JCI’s Series on Clinical Innovation and Scientific Progress in GLP-1 Medicine: www.jci.org/articles/vie...
November 3, 2025 at 8:40 PM
Out now by ASCI member Daniel Drucker @danieljdrucker.bsky.social
Reposted by The American Society for Clinical Investigation
This paper made it to the top of our readership list:
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
November 1, 2025 at 1:01 PM
This paper made it to the top of our readership list:
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress: www.jci.org/articles/vie...
A stretch for gut cells extends our understanding in #BowelDisease
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
October 30, 2025 at 5:38 PM
A stretch for gut cells extends our understanding in #BowelDisease
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
ASCI member Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
Little progress has been made in treatment of anaplastic thyroid cancer
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
October 30, 2025 at 4:06 PM
Little progress has been made in treatment of anaplastic thyroid cancer
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
ASCI member James A. Fagin & team now find mice with aggressive ATC respond to inhibitor combination dabrafenib/trametinib by affecting cancer cell MHCII expression & increasing T-cell infiltration: www.jci.org/articles/vie...
Reposted by The American Society for Clinical Investigation
Today's research assistants, tomorrow's cure-finders:
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
October 29, 2025 at 4:04 PM
Today's research assistants, tomorrow's cure-finders:
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady
Federal funding helps train the next generation of biomedical scientists. By investing in researchers today means investing in decades of future discoveries.
Speak up: http://fundresearch.org
#SaveOurCures #ScienceEducation #FutureReady