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SynOpen journal
@synopenjournal.bsky.social
An #OpenAccess Thieme journal. Fast, Fair & Flexible, and committed to providing an excellent publishing experience through the entire process.
🔬 Prof. Ying Xia and colleagues highlight recent advances in the #synthesis of axially #chiral cycloalkanes, covering key strategies such as asymmetric allylic substitution, #alkene insertion, #carbene cross-coupling, [2+2] #cycloadditions, and #deracemization.

🔗 Read now: bit.ly/4pCRhTy
#ChemSky
November 29, 2025 at 1:21 PM
Potential new type of #herbicides! 🌱
In this paper, J. Frackenpohl & team report the design, #synthesis, and #biological evaluation of substituted azetidinyl carboxamides, developed through scaffold hopping and #bioisosteric strategies.

🔗 Read the full article: bit.ly/4iplJyn
#ChemSky #SAR
November 26, 2025 at 4:50 AM
Prof. Michael P. Doyle & L. De Angelis (UTSA) highlight how 1,2,3-triazine 1-oxides provide a powerful platform for constructing diverse #heterocycles. From nucleophilic substitution & #deoxygenation to Diels–Alder #reactions and more!

🔗 Read the graphical review: bit.ly/48qm7Jg
#ChemSky #Synthesis
November 21, 2025 at 10:32 AM
✨ New Graphical Review!
A. V. Dobrydnev presents overview of synthetic strategies for building endocyclic sulfoximines. They possess unique #physicochemical and structural features, including #chirality and thermal stability.

🔗 Read more: bit.ly/482WRr7
#ChemSky #OrganicChemistry #Heterocycles
November 19, 2025 at 9:02 AM
⚡ In this review, J. Yang & team highlight recent advances in metal-enabled #electrophotocatalysis, integrating photo-, electro-, and metal-catalyzed processes to develop #sustainable routes for C–H activation, #decarboxylation, and cross-coupling under mild conditions.

🔗 Read now: bit.ly/43vqgZH
November 13, 2025 at 9:09 AM
M. V. Kachaeva & team designed and synthesized novel oxazolo[4,5-d]pyrimidine derivatives showing strong activity against glioblastoma and lung #cancer cell lines.

🔍 #MachineLearning, #QSAR modeling, and #docking revealed carbonic anhydrase XII as a potential target.

👉 Read more: bit.ly/47NQt75
November 11, 2025 at 9:01 AM
⚗️ A mild and #metal-free route to 2-hydroxy diarylureas!
This PIFA-mediated ring-opening/coupling of benzoxazoles gives valuable #urea scaffolds with high yields and broad substrate scope.

🔗 Read the full article by M. Yang & team: bit.ly/47rBv81
#ChemSky #OrganicChemistry
November 5, 2025 at 9:00 AM
🌱 From the Virtual Collection: #ClickChemistry and #DrugDiscovery
A simple, metal-free, and eco-friendly approach using chitosan·HCl enables rapid hydrazone #synthesis under mild conditions, delivering high yields and promising #antimycobacterial activity.

🔗 Read here: bit.ly/3WZ09Xl
#ChemSky
November 1, 2025 at 10:44 AM
🧩 From the Virtual Collection: #ClickChemistry and #DrugDiscovery
An efficient click-type formal [2+2] cycloaddition enables the formation of complex #chromophores with remarkable nonlinear optical (NLO) properties.

🔗 Read the full paper: bit.ly/4qpq87O
#ChemSky #OrganicChemistry #OpenAccess
October 23, 2025 at 9:09 AM
⚗️ From Virtual Collection: #ClickChemistry and #DrugDiscovery

N. Jahan & I. Ansary present a review on the synthesis of bioactive macrocycles using ring-closing metathesis, a powerful strategy enabling access to structures with promising #biological activities.

👉 Read here: bit.ly/4hjC3jv
#ChemSky
October 20, 2025 at 9:07 AM
​🚨 LAST CALL! The Thieme #Cheminar starts TODAY.
​Join the session, chaired by our EiC, Prof. Thierry Ollevier.

​Plus: Hear from the SynOpen Most Innovative Paper Award 2024 Winner, Prof. Benjamin Stokes!

⏰️ Starts 3:00 PM (CET).
🔗 Register now: bit.ly/48sqMLq
#ChemSky #Chemistry #Boron
October 16, 2025 at 9:23 AM
Join the next Thieme #Cheminar focusing on the role of boron in #OrganicSynthesis! ​Chaired by our SynOpen Editor-in-Chief, Prof. Thierry Ollevier.

​📅 Oct 16, 3 pm (CEST)

​Don't miss the opportunity to connect with leaders in the field!

​🔗 Secure your spot: bit.ly/48sqMLq
#ChemSky #Chemistry
October 13, 2025 at 8:24 AM
🧩 From the Virtual Collection: #ClickChemistry and #DrugDiscovery
Vinod K. Tiwari & team report a modular and efficient click approach for the synthesis of calix[4]arene-based glycodendrimers bearing lactose (G1) and galactose (G2) units.

👉 Read now: bit.ly/46Vjb5I
#ChemSky
October 7, 2025 at 9:36 AM
✨ From Graphical Reviews Virtual Collection
Liu & Szostak highlight breakthroughs in #amide N–C bond #activation, covering:
⚡ Acyl & decarbonylative coupling
⚡ Nucleophilic acyl addition
⚡ Key mechanistic insights

Read here: www.thieme-connect.com/products/ejo...
#ChemSky #Catalysis #Chemistry
October 1, 2025 at 9:38 AM
🏆 Big news from SynOpen!
The Most Innovative Paper #Award 2024 goes to Benjamin Stokes & team (Santa Clara University, USA) for their breakthrough in Pd-catalyzed transfer #hydrogenation. Congratulations! 🎉 👏

👉 Read more in the full press release + article:
www.thieme.de/en/thieme-ch...
September 27, 2025 at 12:07 PM
⚡ From Graphical Reviews Virtual Collection
#Electrochemistry offers sustainable C–Se bond formation! Explore selenylation, difunctionalization, #cyclization & cross-coupling in this graphical review by Hasimujiang & Ruan.

🔍 Read now:
www.thieme-connect.com/products/ejo...
#ChemSky
September 25, 2025 at 9:24 AM
✨ From Graphical Reviews Collection
#Chemical transformations of indole #alkaloids provide rapid access to novel scaffolds for #DrugDiscovery. Ring distortion strategies re-engineer natural products into diverse bioactive compounds.

🔍 Read now: www.thieme-connect.com/products/ejo...
#ChemSky
September 19, 2025 at 9:31 AM
✨ From Graphical Reviews Virtual Collection
Frustrated Lewis Pairs (FLPs) go beyond H₂ #activation, enabling hydroaminations, #oxidations, cycloisomerizations, and C–C/C–N bond formations.

🔍 Read the graphical #review by Zhou, Tavandashti & Paradies:
www.thieme-connect.com/products/ejo...
#ChemSky
September 16, 2025 at 9:29 AM
🔬 Donor–acceptor azulenes with absorption in the 380–600 nm range & intense blue photoluminescence open new paths for functional materials in organic optoelectronics.

📖 Explore the article by Merkhatuly et al.: www.thieme-connect.com/products/ejo...
#ChemSky #Science
September 12, 2025 at 9:30 AM
⚗️ Vicarious Nucleophilic Substitution (VNS) opens new doors in porphyrin #chemistry!
VNS reaction enables the synthesis of functionalized #porphyrin derivatives with wide synthetic potential.

📖 Explore the graphical review by Ostrowski & Mikus: www.thieme-connect.com/products/ejo...
September 9, 2025 at 8:25 AM
🧪 Explore the latest in #chlorination #science with the graphical review by Vogel, Pinto & Candeias. From green methods to novel reagents, discover sustainable strategies shaping #OrganicSynthesis!

🔗 Read here: www.thieme-connect.com/products/ejo...

#OpenAccess #Chemistry
August 29, 2025 at 8:18 AM
🔬 Explore the synthetic versatility of Woollins’ Reagent (W.R.)! From heterocycle formation to selenoic acid #synthesis, discover its wide-ranging applications! Check out the graphical review by da Silva, Chipoline & Ferreira for more.

🔗 Read here: www.thieme-connect.com/products/ejo...
August 22, 2025 at 8:23 AM
🚀 Big news from SynOpen!

We’ve reached an Impact Factor of 2.1 in the 2024 JCR, placing us in Q3 of ESCI! 🌟

💙 Thanks to our authors, reviewers, board & readers.

Submit your manuscript and join our growing community in #ChemicalSynthesis. Let’s advance #science together—fast, fair & open!
August 21, 2025 at 9:58 AM
Explore the world of #Deuteration! 🧪🔬

This graphical review dives into transition-metal-catalyzed H/D exchange, unraveling #mechanisms, diverse #catalysts, and applications in precise deuterium labeling. Don't miss it!

🔗 Read now: www.thieme-connect.com/products/ejo...
#Chemistry #OpenAccess
August 12, 2025 at 9:20 AM
🌟 Join us for a special #ThiemeCheminar honoring Prof. Erick Carreira! Hear outstanding talks from Profs. T. Ritter, S. Lin @songlin1.bsky.social & S. Reisman @reiswoman.bsky.social.

Chaired by Prof. M. Lautens @marklautens.bsky.social

📅 Aug 14, 2025 ⏰ 3 PM (CET)

👉 Register now: buff.ly/aKtx0Fx
August 8, 2025 at 9:11 AM