Sven T. Stripp
@stripplab.bsky.social
The Spectroscopy & Biocatalysis Group @ Uni Potsdam | DFG Heisenberg Fellow | Guest-Prof TU Berlin 2023/24 | Born at 338 ppm | Not a Strip Club
https://uni-potsdam.de/en/specbiocat | https://scholar.google.com/citations?user=ZtfyzRoAAAAJ&hl=en
https://uni-potsdam.de/en/specbiocat | https://scholar.google.com/citations?user=ZtfyzRoAAAAJ&hl=en
The cat is out of the bag 👍🏻
doi.org/10.22128/jha...
doi.org/10.22128/jha...
November 26, 2025 at 6:33 AM
The cat is out of the bag 👍🏻
doi.org/10.22128/jha...
doi.org/10.22128/jha...
Ornithology 🤝🏻 Inorganic Chemistry
November 25, 2025 at 8:12 PM
Ornithology 🤝🏻 Inorganic Chemistry
Just in: wenn Kleingeld, dann so!
www.stern.de/gesellschaft...
www.stern.de/gesellschaft...
November 24, 2025 at 6:07 PM
Just in: wenn Kleingeld, dann so!
www.stern.de/gesellschaft...
www.stern.de/gesellschaft...
This is what "Editor decision started" looks like
November 24, 2025 at 10:35 AM
This is what "Editor decision started" looks like
The perfect tattoo does not exi...
November 22, 2025 at 1:14 PM
The perfect tattoo does not exi...
Shout-out Volker Schünemann and @kasanmaschefflab.bsky.social for the beautiful spectroscopy!
November 19, 2025 at 5:27 PM
Shout-out Volker Schünemann and @kasanmaschefflab.bsky.social for the beautiful spectroscopy!
Nar1 is another weird guy - looks like a [FeFe]-hydrogenase, appears to be related even, but has no H2 activity. Braymer et al. now report in @chemicalscience.rsc.org that Nar1 from yeast binds a [2Fe-2S] cluster instead of the H-cluster's diiron site. Same but different...
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
November 19, 2025 at 5:03 PM
Nar1 is another weird guy - looks like a [FeFe]-hydrogenase, appears to be related even, but has no H2 activity. Braymer et al. now report in @chemicalscience.rsc.org that Nar1 from yeast binds a [2Fe-2S] cluster instead of the H-cluster's diiron site. Same but different...
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
On the topic of weird "hydrogenases", I stumbled upon this slightly older paper from Heider and Szaleniec et. al: W-dependent aldehyde oxidoreductase (AOR) using H2 to reduce aromatic carboxylic acids (via ACS Catalysis) 🤯
doi.org/10.1021/acsc...
doi.org/10.1021/acsc...
November 19, 2025 at 4:43 PM
On the topic of weird "hydrogenases", I stumbled upon this slightly older paper from Heider and Szaleniec et. al: W-dependent aldehyde oxidoreductase (AOR) using H2 to reduce aromatic carboxylic acids (via ACS Catalysis) 🤯
doi.org/10.1021/acsc...
doi.org/10.1021/acsc...
For tomorrow's GBM Lunch, Adrian Bunzel will talk about creating enzymes by computational design and directed evolution. 12:15 PM CET, oOoOonline!
gbm-online.de/de/gbm-lunch...
gbm-online.de/de/gbm-lunch...
November 18, 2025 at 10:09 PM
For tomorrow's GBM Lunch, Adrian Bunzel will talk about creating enzymes by computational design and directed evolution. 12:15 PM CET, oOoOonline!
gbm-online.de/de/gbm-lunch...
gbm-online.de/de/gbm-lunch...
Don't forget Biochem Donut
November 18, 2025 at 8:26 PM
Don't forget Biochem Donut
POV you eventually decide to rebuttal
November 17, 2025 at 7:57 PM
POV you eventually decide to rebuttal
The Notwist performing their first three albums in front of a solid Gen X audience last night in Berlin. Fun fact: barely any mobile phones raised! 🤗
November 13, 2025 at 7:43 AM
The Notwist performing their first three albums in front of a solid Gen X audience last night in Berlin. Fun fact: barely any mobile phones raised! 🤗
Long-read on [NiFe]-hydrogenase Huc in @laborjournal.bsky.social (German language, RP with a proper image 🤗) www.laborjournal.de/rubric/journ...
November 12, 2025 at 10:14 AM
Long-read on [NiFe]-hydrogenase Huc in @laborjournal.bsky.social (German language, RP with a proper image 🤗) www.laborjournal.de/rubric/journ...
Let's grade this dissertation shall we
November 11, 2025 at 3:39 PM
Let's grade this dissertation shall we
I wonder if anyone ever got rejected from MDPI
November 11, 2025 at 2:28 PM
I wonder if anyone ever got rejected from MDPI
Amazing how easy math can be (with a teenager who always hated school) once it becomes a handy tool you actually need to get a job done... 🙏🏻
November 11, 2025 at 8:33 AM
Amazing how easy math can be (with a teenager who always hated school) once it becomes a handy tool you actually need to get a job done... 🙏🏻
Neubeck & Kirschning celebrate nickel (aka the second best transition metal) and its role in (geo-) chemical and biological evolution
doi.org/10.1016/j.ea...
doi.org/10.1016/j.ea...
November 10, 2025 at 6:50 AM
Neubeck & Kirschning celebrate nickel (aka the second best transition metal) and its role in (geo-) chemical and biological evolution
doi.org/10.1016/j.ea...
doi.org/10.1016/j.ea...
mechanistically, the Zundel ion may "safe-up" one proton to react with the hydride ligand at the H-cluster forming or splitting H2 as rapidly as the specific activities suggest...
Find all the details in our preprint‼️
doi.org/10.26434/che...
Find all the details in our preprint‼️
doi.org/10.26434/che...
November 6, 2025 at 12:40 PM
mechanistically, the Zundel ion may "safe-up" one proton to react with the hydride ligand at the H-cluster forming or splitting H2 as rapidly as the specific activities suggest...
Find all the details in our preprint‼️
doi.org/10.26434/che...
Find all the details in our preprint‼️
doi.org/10.26434/che...
Finally, QM calculations by Federica and Claudio reproduced the experimentally observed differences between Hox and HoxH - the previously mentioned "blue shift" - in the presence of a Zundel ion in the catalytic PT pathway.
November 6, 2025 at 12:40 PM
Finally, QM calculations by Federica and Claudio reproduced the experimentally observed differences between Hox and HoxH - the previously mentioned "blue shift" - in the presence of a Zundel ion in the catalytic PT pathway.
The XRD structure of the E279D variant revealed that protons shall easily travel toward a "conserved" water cluster (H4O2) while in wild-type enzyme, a gap between S319 and E279 blocks PT in the oxidized state.
We suggest that variant E279D can form a so-called "Zundel ion" (H5O2+) at low pH.
We suggest that variant E279D can form a so-called "Zundel ion" (H5O2+) at low pH.
November 6, 2025 at 12:40 PM
The XRD structure of the E279D variant revealed that protons shall easily travel toward a "conserved" water cluster (H4O2) while in wild-type enzyme, a gap between S319 and E279 blocks PT in the oxidized state.
We suggest that variant E279D can form a so-called "Zundel ion" (H5O2+) at low pH.
We suggest that variant E279D can form a so-called "Zundel ion" (H5O2+) at low pH.
So, what might cause the HoxH state? When revisiting our paper from 2018 we were puzzled to find that one variant of the catalytic PT pathway - E279D - seemed to adopt HoxH independent of dithionite. Luckily, this observation was reproducable. 😮💨
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 6, 2025 at 12:40 PM
So, what might cause the HoxH state? When revisiting our paper from 2018 we were puzzled to find that one variant of the catalytic PT pathway - E279D - seemed to adopt HoxH independent of dithionite. Luckily, this observation was reproducable. 😮💨
www.nature.com/articles/s41...
www.nature.com/articles/s41...
the same which is true for the IR profile. All variants adopted the HoxH state at low pH and in the presence of dithionite, just like wild-type enzyme. Can't say I was too happy when the results came in!
😑
😑
November 6, 2025 at 12:40 PM
the same which is true for the IR profile. All variants adopted the HoxH state at low pH and in the presence of dithionite, just like wild-type enzyme. Can't say I was too happy when the results came in!
😑
😑