Srishti Mishra
@srishtimishra.bsky.social
Interested in the neuroscience of decision-making and everything interdisciplinary| Currently 🇫🇮 Previously 🇩🇪🇮🇳🇺🇸| she/her
https://orcid.org/0000-0001-9118-6661
Reposted by Srishti Mishra
How often have you heard that schizophrenia is “80% genetic”?
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 23, 2025 at 11:49 AM
How often have you heard that schizophrenia is “80% genetic”?
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
That number is almost certainly too high because it comes from twin studies that overestimate heritabilty.
Great explainer of this phenomenon👇
#neuroskyence #neuroscience #psychiatry
Reposted by Srishti Mishra
Large-scale chromatin accessibility profiling (ATAC-seq) of neurons and non-neurons from 2 human neocortical regions from 469 unique donors, comprising controls and individuals diagnosed with schizophrenia and bipolar disorder
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development - Nature Neuroscience
This study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain developm...
www.nature.com
November 5, 2025 at 12:22 PM
Large-scale chromatin accessibility profiling (ATAC-seq) of neurons and non-neurons from 2 human neocortical regions from 469 unique donors, comprising controls and individuals diagnosed with schizophrenia and bipolar disorder
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Srishti Mishra
Planet’s first catastrophic climate tipping point reached, with coral reefs facing ‘widespread dieback’
Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale.’
www.theguardian.com/environment/...
Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale.’
www.theguardian.com/environment/...
Planet’s first catastrophic climate tipping point reached, report says, with coral reefs facing ‘widespread dieback’
Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale’, a report by 160 scientists from 23 countries warns
www.theguardian.com
October 14, 2025 at 2:16 PM
Planet’s first catastrophic climate tipping point reached, with coral reefs facing ‘widespread dieback’
Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale.’
www.theguardian.com/environment/...
Unless global heating is reduced to 1.2C ‘as fast as possible’, warm water coral reefs will not remain ‘at any meaningful scale.’
www.theguardian.com/environment/...
Reposted by Srishti Mishra
Great body of work led by @ppiantad.bsky.social
First use of PdCO in the wild to perform closed-loop pre-choice modulation 🤩
www.biorxiv.org/content/10.1...
First use of PdCO in the wild to perform closed-loop pre-choice modulation 🤩
www.biorxiv.org/content/10.1...
October 8, 2025 at 3:25 PM
Great body of work led by @ppiantad.bsky.social
First use of PdCO in the wild to perform closed-loop pre-choice modulation 🤩
www.biorxiv.org/content/10.1...
First use of PdCO in the wild to perform closed-loop pre-choice modulation 🤩
www.biorxiv.org/content/10.1...
Reposted by Srishti Mishra
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
October 2, 2025 at 1:47 PM
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
Reposted by Srishti Mishra
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
September 17, 2025 at 7:33 PM
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
Reposted by Srishti Mishra
Do inhibitory interneurons encode information or just keep the rhythm?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Do inhibitory interneurons encode information or just keep the rhythm?
Inhibitory interneurons may help encode the brain’s internal representation of space
www.science.org
September 4, 2025 at 6:22 PM
Do inhibitory interneurons encode information or just keep the rhythm?
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Srishti Mishra
“Top-down and bottom-up neuroscience: overcoming the clash of research cultures”
doi.org/10.1038/s415...
Small contribution in this piece by @frosas.bsky.social and colleagues on how we need both types of research culture in neuroscience.
#neuroskyence
doi.org/10.1038/s415...
Small contribution in this piece by @frosas.bsky.social and colleagues on how we need both types of research culture in neuroscience.
#neuroskyence
July 22, 2025 at 3:59 PM
“Top-down and bottom-up neuroscience: overcoming the clash of research cultures”
doi.org/10.1038/s415...
Small contribution in this piece by @frosas.bsky.social and colleagues on how we need both types of research culture in neuroscience.
#neuroskyence
doi.org/10.1038/s415...
Small contribution in this piece by @frosas.bsky.social and colleagues on how we need both types of research culture in neuroscience.
#neuroskyence
Reposted by Srishti Mishra
Is criticality a unified setpoint of brain function?: www.cell.com/neuron/fullt...
"We perform a meta-analysis of 140 datasets published between 2003 and 2024. We find that a long-standing controversy is the product of a methodological choice with no bearing on underlying dynamics."
"We perform a meta-analysis of 140 datasets published between 2003 and 2024. We find that a long-standing controversy is the product of a methodological choice with no bearing on underlying dynamics."
June 29, 2025 at 7:22 PM
Is criticality a unified setpoint of brain function?: www.cell.com/neuron/fullt...
"We perform a meta-analysis of 140 datasets published between 2003 and 2024. We find that a long-standing controversy is the product of a methodological choice with no bearing on underlying dynamics."
"We perform a meta-analysis of 140 datasets published between 2003 and 2024. We find that a long-standing controversy is the product of a methodological choice with no bearing on underlying dynamics."
Reposted by Srishti Mishra
In 2023, Ivan Oransky, @thetransmitter.bsky.social’s editor-in-chief, sat down with Gerry Fischbach over several days to listen to—and record for posterity—the story of Fischbach’s life and career.
www.thetransmitter.org/neuroscience...
www.thetransmitter.org/neuroscience...
Neuroscientist Gerry Fischbach, in his own words
In 2023, Ivan Oransky sat down with Gerry Fischbach to hear—and record for posterity—the story of Fischbach’s life and career.
www.thetransmitter.org
May 30, 2025 at 3:03 PM
In 2023, Ivan Oransky, @thetransmitter.bsky.social’s editor-in-chief, sat down with Gerry Fischbach over several days to listen to—and record for posterity—the story of Fischbach’s life and career.
www.thetransmitter.org/neuroscience...
www.thetransmitter.org/neuroscience...
Reposted by Srishti Mishra
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive
function, highlighting gaps in understanding perceived stress, vulnerable developmental
stages, underlying mole...
www.cell.com
May 23, 2025 at 9:35 AM
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
Reposted by Srishti Mishra
When I realized how dangerous the current agency-driven AI trajectory could be for future generations, I knew I had to do all I could to make AI safer. I recently shared this personal experience, and outlined the scientific solution I envision @TEDTalks⤵️
www.ted.com/talks/yoshua...
www.ted.com/talks/yoshua...
The catastrophic risks of AI — and a safer path
Yoshua Bengio — the world's most-cited computer scientist and a "godfather" of artificial intelligence — is deadly concerned about the current trajectory of the technology. As AI models race toward fu...
www.ted.com
May 20, 2025 at 5:17 PM
When I realized how dangerous the current agency-driven AI trajectory could be for future generations, I knew I had to do all I could to make AI safer. I recently shared this personal experience, and outlined the scientific solution I envision @TEDTalks⤵️
www.ted.com/talks/yoshua...
www.ted.com/talks/yoshua...
Reposted by Srishti Mishra
Integrating reproductive states and social cues in the control of sociosexual behaviors
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Integrating reproductive states and social cues in the control of sociosexual behaviors
A subset of neurons in the medial prefrontal cortex is shown to exert top-down regulation
of adaptive innate reproductive behaviors by integrating social cues with estrous
states to orchestrate socios...
www.cell.com
May 21, 2025 at 10:22 AM
Integrating reproductive states and social cues in the control of sociosexual behaviors
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Srishti Mishra
A very special 150th episode - I got to interview the one-and-only Eve Marder! Check it out to learn more about her life and science, and highly recommend listening to the interview to hear her many fabulous stories and her words of wisdom, my personal favorite being about how she found her ‘voice’
Check out our latest profile! Dr. Eve Marder studies the stability and flexibility of neural circuit function. Follow the link below to learn more!
www.storiesofwin.org/profiles/202...
#StoriesofWiN #WomenInNeuroscience #WomenInNeuro
www.storiesofwin.org/profiles/202...
#StoriesofWiN #WomenInNeuroscience #WomenInNeuro
May 14, 2025 at 11:13 PM
A very special 150th episode - I got to interview the one-and-only Eve Marder! Check it out to learn more about her life and science, and highly recommend listening to the interview to hear her many fabulous stories and her words of wisdom, my personal favorite being about how she found her ‘voice’
Today’s editorial in @thehindu.com about academic freedom in India
May 13, 2025 at 10:45 AM
Today’s editorial in @thehindu.com about academic freedom in India
Reposted by Srishti Mishra
In 1984, Francis Crick described a biological conundrum: Memories last years, while most molecules degrade in days or weeks. “How then is memory stored in the brain so that its trace is relatively immune to molecular turnover?” www.quantamagazine.org/the-molecula... #memory #Crick #philsky
The Molecular Bond That Helps Secure Your Memories | Quanta Magazine
How do memories last a lifetime when the molecules that form them turn over within days, weeks or months? An interaction between two proteins points to a molecular basis for memory.
www.quantamagazine.org
May 9, 2025 at 6:09 PM
In 1984, Francis Crick described a biological conundrum: Memories last years, while most molecules degrade in days or weeks. “How then is memory stored in the brain so that its trace is relatively immune to molecular turnover?” www.quantamagazine.org/the-molecula... #memory #Crick #philsky
Reposted by Srishti Mishra
🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse...
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
May 3, 2025 at 7:12 PM
🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse...
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
Reposted by Srishti Mishra
⚠️Permanent position (E13) as lab manager (psychophysiology, experimental behavioral neuroscience) at University of Bielefeld. Earliest starting date is in July but later is absolutely possible. Please share widely uni-bielefeld.hr4you.org/job/view/427...
Laborleiter*in (m/w/d) Psychophysiologie und Verha...
In der Fakultät für Psychologie und Sportwissenschaft ist zum nächstmöglichen Zeitpunkt die Stelle der*des Laborleiter*in (TV-L E12 bzw. E13) im B...
uni-bielefeld.hr4you.org
April 24, 2025 at 1:06 PM
⚠️Permanent position (E13) as lab manager (psychophysiology, experimental behavioral neuroscience) at University of Bielefeld. Earliest starting date is in July but later is absolutely possible. Please share widely uni-bielefeld.hr4you.org/job/view/427...
Reposted by Srishti Mishra
Reposted by Srishti Mishra
Albert Einstein died on this day, April 18, 1955.
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
April 18, 2025 at 1:12 PM
Albert Einstein died on this day, April 18, 1955.
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
Reposted by Srishti Mishra
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
Smell studies often use unnaturally high odor concentrations, analysis reveals
It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.
www.thetransmitter.org
April 16, 2025 at 2:26 PM
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
Reposted by Srishti Mishra
"The answer to science’s influence problem is not trust building but rather aiding better-placed confidence and communicating the truth in a more compelling way, one that does not assume a lack of competing sources or that everyone is playing by the same rules of evidence." 🧪
Science’s big problem is a loss of influence, not a loss of trust
Evidence shows that science and scientists remain highly trusted. But genuine scientific voices are not shouting loud enough over the noise to hold sway.
www.nature.com
April 13, 2025 at 10:52 PM
"The answer to science’s influence problem is not trust building but rather aiding better-placed confidence and communicating the truth in a more compelling way, one that does not assume a lack of competing sources or that everyone is playing by the same rules of evidence." 🧪
Reposted by Srishti Mishra
Layer-specific input to medial prefrontal cortex is linked to stress susceptibility
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Layer-specific input to medial prefrontal cortex is linked to stress susceptibility - Translational Psychiatry
Translational Psychiatry - Layer-specific input to medial prefrontal cortex is linked to stress susceptibility
www.nature.com
April 10, 2025 at 11:34 AM
Layer-specific input to medial prefrontal cortex is linked to stress susceptibility
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Srishti Mishra
And we need to embrace the likely possibility that brains are more than connectivity patterns and their weightings. That is the start, not the end.
Accepting “the bitter lesson” and embracing the brain’s complexity
www.thetransmitter.org/neuroai/acce...
#neuroscience
Accepting “the bitter lesson” and embracing the brain’s complexity
www.thetransmitter.org/neuroai/acce...
#neuroscience
Accepting “bitter lesson” and embracing brain’s complexity
To gain insight into complex neural data, we must move toward a data-driven regime, employing large models trained on vast amounts of data. Experts weigh in.
www.thetransmitter.org
March 26, 2025 at 5:46 PM
And we need to embrace the likely possibility that brains are more than connectivity patterns and their weightings. That is the start, not the end.
Accepting “the bitter lesson” and embracing the brain’s complexity
www.thetransmitter.org/neuroai/acce...
#neuroscience
Accepting “the bitter lesson” and embracing the brain’s complexity
www.thetransmitter.org/neuroai/acce...
#neuroscience
Reposted by Srishti Mishra
Split-Brain: Two Selves in One?
The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it. www.thecollector.com/split-brain-... #self #splitbrain #philsky #science
The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it. www.thecollector.com/split-brain-... #self #splitbrain #philsky #science
Split-Brain: Two Selves in One? | TheCollector
The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it.
www.thecollector.com
March 13, 2025 at 2:36 PM
Split-Brain: Two Selves in One?
The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it. www.thecollector.com/split-brain-... #self #splitbrain #philsky #science
The nature of self is a philosophical problem that has truly stood the test of time—split-brain patients are one of the few times something tangible may give us insights into it. www.thecollector.com/split-brain-... #self #splitbrain #philsky #science