Sjors Scheres
@sjorsscheres.bsky.social
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
In this case, no one has ever been able to replicate the structures extracted from brains with Lewy pathology or MSA using recombinant aSyn. Attempts to do so have led to different structures (e.g. see below).
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
The assembly of certain proteins into amyloids underlies multiple neurodegenerative diseases. The spreading of these assemblies through the brain is thought to occur through a prion-like mechanism. W....
febs.onlinelibrary.wiley.com
November 17, 2025 at 9:33 AM
In this case, no one has ever been able to replicate the structures extracted from brains with Lewy pathology or MSA using recombinant aSyn. Attempts to do so have led to different structures (e.g. see below).
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
It would be a step forward if all @cellpress.bsky.social journals would publish their review reports, so one could at least understand what happened during the publication process. Transparency is good.
November 17, 2025 at 8:24 AM
It would be a step forward if all @cellpress.bsky.social journals would publish their review reports, so one could at least understand what happened during the publication process. Transparency is good.
AI will be even more susceptible than the human herd to get stuck in incorrect local minima on our path towards truth. ☹️
November 9, 2025 at 9:17 AM
AI will be even more susceptible than the human herd to get stuck in incorrect local minima on our path towards truth. ☹️
Jokes aside, for those of you taking long flights: keep moving around & drink plenty. A deep vein thrombosis is dangerous and extremely painful; I don't recommend it. I'm not overweight, not a smoker or heavy drinker, and in excellent physical shape. My only risk factor was being a 40+ male.
October 27, 2025 at 9:25 AM
Jokes aside, for those of you taking long flights: keep moving around & drink plenty. A deep vein thrombosis is dangerous and extremely painful; I don't recommend it. I'm not overweight, not a smoker or heavy drinker, and in excellent physical shape. My only risk factor was being a 40+ male.
Apparently, I am "take 12 weeks of anti-coagulant and lots of paracetamol after a transatlantic flight" years old. ☹️
October 27, 2025 at 8:36 AM
Apparently, I am "take 12 weeks of anti-coagulant and lots of paracetamol after a transatlantic flight" years old. ☹️
Reposted by Sjors Scheres
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!
October 24, 2025 at 8:58 PM
We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!