Sjors Scheres
@sjorsscheres.bsky.social
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
That message is summarised in the paragraph below. It explains a lot...
September 15, 2025 at 6:58 PM
That message is summarised in the paragraph below. It explains a lot...
I very much enjoyed this book by Gary Stevenson, who was a top trader in the City, until he couldn't do it anymore. His style is entertaining and his message couldn't be more important these days.
September 15, 2025 at 6:54 PM
I very much enjoyed this book by Gary Stevenson, who was a top trader in the City, until he couldn't do it anymore. His style is entertaining and his message couldn't be more important these days.
I thought this book made some good points on why we need to, how difficult this may be, but how we might in the end, contain upcoming #AI technologies. However, I disliked the constant parallels with #biotech. It seems common among successful people in #AI to underestimate how hard biology is.
August 25, 2025 at 5:04 PM
Just cycled the Pennine Bridle Way from the northern Dales to the Peak District. England can be wild! 265km and 6,200m height over 4 days; 24hrs in the saddle. Beautiful terrain, but very hard cycling (and a fair bit of walking).
August 17, 2025 at 4:55 PM
Just cycled the Pennine Bridle Way from the northern Dales to the Peak District. England can be wild! 265km and 6,200m height over 4 days; 24hrs in the saddle. Beautiful terrain, but very hard cycling (and a fair bit of walking).
We have revised our preprint on #PAD12 tau.
We have included new data on obtaining 95+% pure #Alzheimers PHFs, and further data to support our mechanistic model how phosphorylation in tau's fuzzy coat facilitates its assembly into #amyloid filaments.
www.biorxiv.org/content/10.1...
We have included new data on obtaining 95+% pure #Alzheimers PHFs, and further data to support our mechanistic model how phosphorylation in tau's fuzzy coat facilitates its assembly into #amyloid filaments.
www.biorxiv.org/content/10.1...
August 1, 2025 at 9:41 AM
We have revised our preprint on #PAD12 tau.
We have included new data on obtaining 95+% pure #Alzheimers PHFs, and further data to support our mechanistic model how phosphorylation in tau's fuzzy coat facilitates its assembly into #amyloid filaments.
www.biorxiv.org/content/10.1...
We have included new data on obtaining 95+% pure #Alzheimers PHFs, and further data to support our mechanistic model how phosphorylation in tau's fuzzy coat facilitates its assembly into #amyloid filaments.
www.biorxiv.org/content/10.1...
Just finished this wonderful book by @jacindaardern.bsky.social. If only more politicians would be like this brave woman, the world would be so different! Read this book and be inspired for a kinder future.
July 29, 2025 at 2:06 PM
Just finished this wonderful book by @jacindaardern.bsky.social. If only more politicians would be like this brave woman, the world would be so different! Read this book and be inspired for a kinder future.
This should be fun today!
July 8, 2025 at 8:21 AM
This should be fun today!
Many congratulations to Dr Kiarash Jamali @kjamali.bsky.social for successfully defending his PhD thesis today! 🥳 Also many thanks to Jonas Adler and Randy Read for examining him. I expect great things from Dr Jamali in his career, so do keep an eye on him. #ModelAngelo
July 7, 2025 at 8:23 PM
Many congratulations to Dr Kiarash Jamali @kjamali.bsky.social for successfully defending his PhD thesis today! 🥳 Also many thanks to Jonas Adler and Randy Read for examining him. I expect great things from Dr Jamali in his career, so do keep an eye on him. #ModelAngelo
Although the density at the centre of the cap remains too poor for atomic modeling, it suggests the presence of a 13-stranded beta-barrel that sits within a larger 26-stranded barrel. Given the hydrophobic nature of the corresponding residues, this would form a greasy gate to the vault.
May 28, 2025 at 7:43 AM
Although the density at the centre of the cap remains too poor for atomic modeling, it suggests the presence of a 13-stranded beta-barrel that sits within a larger 26-stranded barrel. Given the hydrophobic nature of the corresponding residues, this would form a greasy gate to the vault.
At its caps, there is no space for 39 MVPs. Using symmetry expansion and partial signal subtraction in #RELION, we show that the symmetry at the caps is broken and 2 out of every 3 MVP monomers gets successively excluded from the cap.
May 28, 2025 at 7:40 AM
At its caps, there is no space for 39 MVPs. Using symmetry expansion and partial signal subtraction in #RELION, we show that the symmetry at the caps is broken and 2 out of every 3 MVP monomers gets successively excluded from the cap.
At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.
April 10, 2025 at 5:22 PM
At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.
Who wants to tell them that alpha-synuclein filaments are associated with Parkinson's disease, not Alzheimer's... 🤪
April 3, 2025 at 9:28 PM
Who wants to tell them that alpha-synuclein filaments are associated with Parkinson's disease, not Alzheimer's... 🤪
I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱
How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?
How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?
April 1, 2025 at 7:42 PM
I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱
How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?
How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?
Finished this book today. With everything going on in the US right now, many more people should read it, especially our politicians.
March 30, 2025 at 2:53 PM
Finished this book today. With everything going on in the US right now, many more people should read it, especially our politicians.
Having read its rather sensationalist marketing, I started reading "Doctored" by @charlespiller.bsky.social with the intention of hating it. However, I ended up appreciating this book as a much-needed reminder of the importance of doing solid science. I will encourage my trainees to read it.
March 18, 2025 at 9:33 AM
Having read its rather sensationalist marketing, I started reading "Doctored" by @charlespiller.bsky.social with the intention of hating it. However, I ended up appreciating this book as a much-needed reminder of the importance of doing solid science. I will encourage my trainees to read it.
It was 19C and sunny today in Cambridge, so we had a lovely summery ride, even wearing shorts! Lots of mostly dry tracks through the fields, totaling 72km over 3.5hrs with 620m overall height (not bad for our flat countryside, huh?)
March 9, 2025 at 5:54 PM
It was 19C and sunny today in Cambridge, so we had a lovely summery ride, even wearing shorts! Lots of mostly dry tracks through the fields, totaling 72km over 3.5hrs with 620m overall height (not bad for our flat countryside, huh?)
Instead of being based on crazy fictional ideas, these science fiction series are creative and valuable warnings about the risks of authoritarian regimes that are informed by sociology, psychology, and by the past. Perhaps the logo of the Visitors in "V" reminds you of another one?
March 2, 2025 at 12:25 PM
Instead of being based on crazy fictional ideas, these science fiction series are creative and valuable warnings about the risks of authoritarian regimes that are informed by sociology, psychology, and by the past. Perhaps the logo of the Visitors in "V" reminds you of another one?
I suspect the reported number of followers on X are no longer reflecting reality. My X profile says it is no longer active, I replaced the picture with a bluesky logo, and I have deleted all my tweets. Still, I get as many new "followers" there than here... 🤔
January 19, 2025 at 9:37 AM
I suspect the reported number of followers on X are no longer reflecting reality. My X profile says it is no longer active, I replaced the picture with a bluesky logo, and I have deleted all my tweets. Still, I get as many new "followers" there than here... 🤔
2024 was good for cycling: no major injuries, so did 180 hours, 3.5 Mm distance with 30 km elevation. Grateful to my various buddies for their companionship; also happy my 21 year old Orbea MTB is still going strong in Spain!
December 29, 2024 at 1:17 PM
2024 was good for cycling: no major injuries, so did 180 hours, 3.5 Mm distance with 30 km elevation. Grateful to my various buddies for their companionship; also happy my 21 year old Orbea MTB is still going strong in Spain!
Goodbye twitter. We had some good times. Just unfollowed everyone and deleted all my tweets...
December 23, 2024 at 6:16 PM
Goodbye twitter. We had some good times. Just unfollowed everyone and deleted all my tweets...
This paper contains some interesting data on tau, but the #cryoEM structure should not have been published like this by @pnas.org. Conclusions drawn about its symmetry and its resemblance to PHFs from #Alzheimer brain are not supported by the data.
www.pnas.org/doi/10.1073/...
December 22, 2024 at 10:24 AM
This paper contains some interesting data on tau, but the #cryoEM structure should not have been published like this by @pnas.org. Conclusions drawn about its symmetry and its resemblance to PHFs from #Alzheimer brain are not supported by the data.
www.pnas.org/doi/10.1073/...
Yay, the @pdbeurope.bsky.social 2025 calendar arrived today! The careful annotation and curation of protein structures for so many years by the PDB was key for this year's @nobelprize.bsky.social in chemistry for protein structure prediction. 🥳🥳🥳
December 10, 2024 at 9:00 AM
Yay, the @pdbeurope.bsky.social 2025 calendar arrived today! The careful annotation and curation of protein structures for so many years by the PDB was key for this year's @nobelprize.bsky.social in chemistry for protein structure prediction. 🥳🥳🥳
I have written to the senior author that the #cryoEM #amyloid structure in this @biorxivpreprint.bsky.social is of insufficient quality for publication, and offered my help to fix it.
November 30, 2024 at 8:45 AM
I have written to the senior author that the #cryoEM #amyloid structure in this @biorxivpreprint.bsky.social is of insufficient quality for publication, and offered my help to fix it.