Siegel Lab
@siegel-lab.bsky.social
We use T. brucei to study the role of chromatin and genome architecture in antigenic variation.
https://www.vetmed.lmu.de/molpara/en/
https://www.vetmed.lmu.de/molpara/en/
Pinned
Siegel Lab
@siegel-lab.bsky.social
· Jul 18
We’re very excited about the potential of IACS for advancing infectious disease research and believe this review from the Goda lab and its collaborators in @natrevbioeng.nature.com highlights its many powerful applications. Check out the full paper here: www.nature.com/articles/s44...
Reposted by Siegel Lab
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications
A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...
www.nature.com
July 21, 2025 at 10:53 AM
Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
www.nature.com/articles/s41...
Congratulations to Kai and Oyvind!!
We’re very excited about the potential of IACS for advancing infectious disease research and believe this review from the Goda lab and its collaborators in @natrevbioeng.nature.com highlights its many powerful applications. Check out the full paper here: www.nature.com/articles/s44...
July 18, 2025 at 9:21 AM
We’re very excited about the potential of IACS for advancing infectious disease research and believe this review from the Goda lab and its collaborators in @natrevbioeng.nature.com highlights its many powerful applications. Check out the full paper here: www.nature.com/articles/s44...
Reposted by Siegel Lab
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
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www.biorxiv.org/content/10.1...
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July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
We’re excited to share our review: "Next-generation genetic screens in kinetoplastids", now published in NAR!
It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting.
academic.oup.com/nar/article/...
It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting.
academic.oup.com/nar/article/...
Next generation genetic screens in kinetoplastids
Abstract. The genomes of all organisms encode diverse functional elements, including thousands of genes and essential noncoding regions for gene regulation
academic.oup.com
June 23, 2025 at 12:57 PM
We’re excited to share our review: "Next-generation genetic screens in kinetoplastids", now published in NAR!
It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting.
academic.oup.com/nar/article/...
It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting.
academic.oup.com/nar/article/...
Reposted by Siegel Lab
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
May 19, 2025 at 1:23 PM
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
Reposted by Siegel Lab
New online! RNA splicing — a central layer of gene regulation
RNA splicing — a central layer of gene regulation
Nature Reviews Genetics, Published online: 21 May 2025; doi:10.1038/s41576-025-00846-xTechnological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning, have substantially deepened our understanding of RNA splicing. Nature Reviews Genetics and Nature Reviews Molecular Cell Biology present an online collection that showcases the novel biological insights facilitated by these advances.
www.nature.com
May 21, 2025 at 1:59 PM
New online! RNA splicing — a central layer of gene regulation
Reposted by Siegel Lab
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome
https://go.nature.com/4kcNObU
https://go.nature.com/4kcNObU
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.
go.nature.com
May 7, 2025 at 5:33 PM
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome
https://go.nature.com/4kcNObU
https://go.nature.com/4kcNObU
Reposted by Siegel Lab
These boxes are not moving. A mind-bending optical illusion by Japanese artist Jagarikin.
May 7, 2025 at 1:03 AM
These boxes are not moving. A mind-bending optical illusion by Japanese artist Jagarikin.
Reposted by Siegel Lab
Our latest collaborative work with Keith Matthews’ lab using synthetic DNA binding proteins to explore the chromatin protein contexts of repetitive sequences in Trypanosoma brucei in now on bioRxiv - thanks to all involved! 2025.04.22.649942; doi: doi.org/10.1101/2025...
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...
doi.org
April 24, 2025 at 12:11 PM
Our latest collaborative work with Keith Matthews’ lab using synthetic DNA binding proteins to explore the chromatin protein contexts of repetitive sequences in Trypanosoma brucei in now on bioRxiv - thanks to all involved! 2025.04.22.649942; doi: doi.org/10.1101/2025...
Very much looking forward to it.
Register for the excellent Epigenetics Gordon Research Conference Barcelona 10-15 Aug25. Theme: Epigenetic Variation: Mechanisms & Impact Across Systems. **FUNDING AVAILABLE to support attendance** ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
May 5, 2025 at 7:13 PM
Very much looking forward to it.
Reposted by Siegel Lab
Register for the excellent Epigenetics Gordon Research Conference Barcelona 10-15 Aug25. Theme: Epigenetic Variation: Mechanisms & Impact Across Systems. **FUNDING AVAILABLE to support attendance** ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
April 30, 2025 at 9:28 PM
Register for the excellent Epigenetics Gordon Research Conference Barcelona 10-15 Aug25. Theme: Epigenetic Variation: Mechanisms & Impact Across Systems. **FUNDING AVAILABLE to support attendance** ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
Reposted by Siegel Lab
In the silence of chromatin, Toxoplasma whispers change.
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii
Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...
rdcu.be
April 11, 2025 at 11:07 AM
In the silence of chromatin, Toxoplasma whispers change.
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.
Now in Nature Microbiology:
rdcu.be/ehkWp
Reposted by Siegel Lab
Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social
Very happy to see this come to fruition- Look forward to feedback from colleagues !
More 👉 www.cell.com/cell/fulltex...
Very happy to see this come to fruition- Look forward to feedback from colleagues !
More 👉 www.cell.com/cell/fulltex...
April 23, 2025 at 3:26 PM
Here is-🥳🥳😇 tremendous effort by @palmrinmoy.bsky.social brilliantly supported by @tamas-schauer.bsky.social &super help by federico,iliya,tsune,adam,@mamartirenom.bsky.social
Very happy to see this come to fruition- Look forward to feedback from colleagues !
More 👉 www.cell.com/cell/fulltex...
Very happy to see this come to fruition- Look forward to feedback from colleagues !
More 👉 www.cell.com/cell/fulltex...
Great work.
#midweekmicro🔬
Parasite and vector circadian clocks mediate efficient malaria transmission🦟
@naturemicrobiol.bsky.social #microsky
www.nature.com/articles/s41...
Parasite and vector circadian clocks mediate efficient malaria transmission🦟
@naturemicrobiol.bsky.social #microsky
www.nature.com/articles/s41...
Parasite and vector circadian clocks mediate efficient malaria transmission - Nature Microbiology
Mosquito salivary glands and malaria parasites exhibit daily rhythms, which impact blood feeding and sporozoite gene expression.
www.nature.com
April 2, 2025 at 12:45 PM
Great work.
If you are interested in antigenic variation, you may have wondered how parasites ‘select’ which antigen to express next.
Our manuscript, just published in Nature, provides some answers!
www.nature.com/articles/s41...
@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com
Our manuscript, just published in Nature, provides some answers!
www.nature.com/articles/s41...
@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com
March 12, 2025 at 4:31 PM
If you are interested in antigenic variation, you may have wondered how parasites ‘select’ which antigen to express next.
Our manuscript, just published in Nature, provides some answers!
www.nature.com/articles/s41...
@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com
Our manuscript, just published in Nature, provides some answers!
www.nature.com/articles/s41...
@lmumuenchen.bsky.social
@erc.europa.eu a.eu
@nature.com
Reposted by Siegel Lab
#AidJobs: We are hiring, here is your chance to work with us.
International Secretary General: bit.ly/42VhaWN
Deputy Logistics Coordinator: bit.ly/4gIVDUf
Tembo Support Officer: bit.ly/4gJ9WIK
5 Nutritionists- bit.ly/3CVtzPW
Finance and Human Resources Manager: bit.ly/3QjZLzo
International Secretary General: bit.ly/42VhaWN
Deputy Logistics Coordinator: bit.ly/4gIVDUf
Tembo Support Officer: bit.ly/4gJ9WIK
5 Nutritionists- bit.ly/3CVtzPW
Finance and Human Resources Manager: bit.ly/3QjZLzo
February 18, 2025 at 2:40 PM
#AidJobs: We are hiring, here is your chance to work with us.
International Secretary General: bit.ly/42VhaWN
Deputy Logistics Coordinator: bit.ly/4gIVDUf
Tembo Support Officer: bit.ly/4gJ9WIK
5 Nutritionists- bit.ly/3CVtzPW
Finance and Human Resources Manager: bit.ly/3QjZLzo
International Secretary General: bit.ly/42VhaWN
Deputy Logistics Coordinator: bit.ly/4gIVDUf
Tembo Support Officer: bit.ly/4gJ9WIK
5 Nutritionists- bit.ly/3CVtzPW
Finance and Human Resources Manager: bit.ly/3QjZLzo
Hope we can join this meeting again this year.
February 14, 2025 at 10:29 AM
Hope we can join this meeting again this year.
Reposted by Siegel Lab
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
February 4, 2025 at 9:22 AM
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport 🧪 @plosbiology.org plos.io/3Q36QV2
Reposted by Siegel Lab
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
January 23, 2025 at 1:47 PM
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
I’m very much looking forward to attending the symposium and to celebrate the career of Mark Carrington.
🚨 Retirement Symposium for Prof Mark Carrington of the University of Cambridge
Our #Trypanosoma colleagues may want to attend this symposium in Cambridge on the 𝟐𝟒𝐭𝐡 𝐨𝐟 𝐌𝐚𝐫𝐜𝐡, 2025 (register by the 15th!)
- Details at QR code & tinyurl.com/2uw8tryu
Our #Trypanosoma colleagues may want to attend this symposium in Cambridge on the 𝟐𝟒𝐭𝐡 𝐨𝐟 𝐌𝐚𝐫𝐜𝐡, 2025 (register by the 15th!)
- Details at QR code & tinyurl.com/2uw8tryu
January 16, 2025 at 8:22 PM
I’m very much looking forward to attending the symposium and to celebrate the career of Mark Carrington.
Reposted by Siegel Lab
We have a feeling you'll be interested in this one.
Nature is keen to find out how scientists are using Bluesky and whether it has become their go-to social-media platform. Take the survey! 🧪
Nature is keen to find out how scientists are using Bluesky and whether it has become their go-to social-media platform. Take the survey! 🧪
Has Bluesky replaced X for scientists? Take Nature’s poll
The research community has flocked to the social-media platform Bluesky. Tell us about your experience.
go.nature.com
January 14, 2025 at 11:39 PM
We have a feeling you'll be interested in this one.
Nature is keen to find out how scientists are using Bluesky and whether it has become their go-to social-media platform. Take the survey! 🧪
Nature is keen to find out how scientists are using Bluesky and whether it has become their go-to social-media platform. Take the survey! 🧪
That is why we left.
IMPORTANT UPDATE ❗In a joint initiative, more than 60 German universities and research institutions are leaving the Platform #X. They want to set an example against hatred and hate speech.
www.dw.com/en/german-in...
#socialmedia #research #science #Musk
www.dw.com/en/german-in...
#socialmedia #research #science #Musk
German institutions depart X, a day after Musk's Weidel talk – DW – 01/10/2025
More than 60 German and Austrian academic organizations say they will leave the messaging platform X owned by Elon Musk. The German government has also voiced fears that the platform is warping politi...
www.dw.com
January 14, 2025 at 3:06 PM
That is why we left.
Reposted by Siegel Lab
🚨 Final abstract submission by tomorrow for #BSP2025 in Würzburg! 🚨
- Abstract submission by 𝟏𝟓𝐭𝐡 𝐉𝐚𝐧𝐮𝐚𝐫𝐲 𝟐𝟎𝟐𝟓 at tinyurl.com/5c2jn5zs
- You can register (early bird registration until the 10th February) at tinyurl.com/3x32vycr
- Abstract submission by 𝟏𝟓𝐭𝐡 𝐉𝐚𝐧𝐮𝐚𝐫𝐲 𝟐𝟎𝟐𝟓 at tinyurl.com/5c2jn5zs
- You can register (early bird registration until the 10th February) at tinyurl.com/3x32vycr
January 14, 2025 at 2:28 PM
🚨 Final abstract submission by tomorrow for #BSP2025 in Würzburg! 🚨
- Abstract submission by 𝟏𝟓𝐭𝐡 𝐉𝐚𝐧𝐮𝐚𝐫𝐲 𝟐𝟎𝟐𝟓 at tinyurl.com/5c2jn5zs
- You can register (early bird registration until the 10th February) at tinyurl.com/3x32vycr
- Abstract submission by 𝟏𝟓𝐭𝐡 𝐉𝐚𝐧𝐮𝐚𝐫𝐲 𝟐𝟎𝟐𝟓 at tinyurl.com/5c2jn5zs
- You can register (early bird registration until the 10th February) at tinyurl.com/3x32vycr
Reposted by Siegel Lab
Have you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach?
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
January 13, 2025 at 8:28 PM
Have you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach?
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social