In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s odour response and courtship behaviour.

Abstract. Heterozygous missense variants in CDK19 have been found in patients diagnosed with Developmental and Epileptic Encephalopathy-87 (DEE87) who pres

Adult intestinal plasticity and tissue repair involves complex and reciprocal multicellular interactions. Medina, Perochon, et al. report a signaling axis between hormone-producing cells in the intest...

The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.

This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular network...

The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive age-related muscle decline, u...

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Mariana Wolfner has spent her life studying a creature so small it could rest on the tip of her finger. In her hands, the fruit fly Drosophila melanogaster becomes something extraordinary, a key to understanding how life is shaped, sustained, and passed on. On a windy fall afternoon at Cornell, she sat surrounded by papers, notes, and journals. The light came through the window in soft bands as she lifted a golden model of a fly and smiled.

The peptide hormone Capa is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster.

Effective tissue adaptation to damage requires precise coordination among diverse cell types. In skeletal muscle, injury-responsive cells play a pivotal role in repair, yet the molecular and cellular ...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Michael Ashburner had an extraordinary career. From his early passion for natural history, through his education and subsequent career at the University of Cambridge, Michael’s intellectual energy and...

Electricity is an omnipresent force in the natural world. A new study shows that the larvae of Drosophila melanogaster respond behaviourally to electric fields and identifies a single pair of neurons ...