Serge Mostowy
@sergemostowylab.bsky.social
Reposted by Serge Mostowy
Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction.
Credit to @dominikrobak.bsky.social for the stunning cover image!
Credit to @dominikrobak.bsky.social for the stunning cover image!
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
November 24, 2025 at 6:01 PM
Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction.
Credit to @dominikrobak.bsky.social for the stunning cover image!
Credit to @dominikrobak.bsky.social for the stunning cover image!
Reposted by Serge Mostowy
London interdisciplinary #PhD position now open with myself, @sergemostowylab.bsky.social, & @gmknght.bsky.social on #phage -bacteria-host immune dynamics for WHO priority bacterial pathogens #Klebsiella, #Shigella, and #Staph. Combines cellular microbiology, genomics, & mathematical modelling.
2026-27 Project (Dyson & Mostowy & Knight) - MRC London Intercollegiate Doctoral Training Partnership Studentships
PHACTS: Unravelling PHAge-baCTeria-host immune dynamicS to inform phage therapy SUPERVISORY TEAM Supervisor Dr Zoe Dyson...
mrc-lid.lshtm.ac.uk
November 13, 2025 at 11:11 AM
London interdisciplinary #PhD position now open with myself, @sergemostowylab.bsky.social, & @gmknght.bsky.social on #phage -bacteria-host immune dynamics for WHO priority bacterial pathogens #Klebsiella, #Shigella, and #Staph. Combines cellular microbiology, genomics, & mathematical modelling.
Reposted by Serge Mostowy
also worthwhile checking out the highlight commentary by
@kewright.bsky.social and @sergemostowylab.bsky.social:
No guts, no glory: IL-26 in host-microbiota interactions
www.embopress.org/doi/full/10....
@kewright.bsky.social and @sergemostowylab.bsky.social:
No guts, no glory: IL-26 in host-microbiota interactions
www.embopress.org/doi/full/10....
No guts, no glory: IL-26 in host-microbiota interactions | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 23, 2025 at 2:10 PM
also worthwhile checking out the highlight commentary by
@kewright.bsky.social and @sergemostowylab.bsky.social:
No guts, no glory: IL-26 in host-microbiota interactions
www.embopress.org/doi/full/10....
@kewright.bsky.social and @sergemostowylab.bsky.social:
No guts, no glory: IL-26 in host-microbiota interactions
www.embopress.org/doi/full/10....
No guts, no glory: IL-26 in host-microbiota interactions
@embojournal.org
www.embopress.org/doi/full/10....
@embojournal.org
www.embopress.org/doi/full/10....
No guts, no glory: IL-26 in host-microbiota interactions | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 22, 2025 at 4:33 PM
No guts, no glory: IL-26 in host-microbiota interactions
@embojournal.org
www.embopress.org/doi/full/10....
@embojournal.org
www.embopress.org/doi/full/10....
Reposted by Serge Mostowy
Don't let the bug's virulence fill you with dread,
When gourmet French dining awaits you instead.
So pack up your notes and your best, clever wits,
To discuss all the bug's crafty cellular tricks!
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
When gourmet French dining awaits you instead.
So pack up your notes and your best, clever wits,
To discuss all the bug's crafty cellular tricks!
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
Home - EMBO Workshop Shigella: from biology to prevention
EMBO Workshop Shigella: from biology to prevention
www.shigella2026.conferences-pasteur.org
October 21, 2025 at 3:39 PM
Don't let the bug's virulence fill you with dread,
When gourmet French dining awaits you instead.
So pack up your notes and your best, clever wits,
To discuss all the bug's crafty cellular tricks!
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
When gourmet French dining awaits you instead.
So pack up your notes and your best, clever wits,
To discuss all the bug's crafty cellular tricks!
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
Reposted by Serge Mostowy
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
October 13, 2025 at 9:48 PM
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
Reposted by Serge Mostowy
Attention #Septin Fans! Serge Mostowy's lab @sergemostowylab.bsky.social published a wonderful #openacces short report in #CYTOSKELETON.Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death. onlinelibrary.wiley.com/doi/full/10....
October 6, 2025 at 2:46 PM
Attention #Septin Fans! Serge Mostowy's lab @sergemostowylab.bsky.social published a wonderful #openacces short report in #CYTOSKELETON.Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death. onlinelibrary.wiley.com/doi/full/10....
Reposted by Serge Mostowy
This year's Crick @crick.ac.uk PhD programme is open for applications
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
Briscoe Lab | Cellular Dynamics and Pattern Formation in Vertebrate Development
www.crick.ac.uk
October 6, 2025 at 11:37 AM
This year's Crick @crick.ac.uk PhD programme is open for applications
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
- £27,715 tax-free student stipend per year for 4 years
- Tuition fees paid
- Student visa fee & health surcharges covered
Deadline 5 Nov
We have a project available. For all the details visit:
www.crick.ac.uk/careers-stud...
Reposted by Serge Mostowy
The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1
October 5, 2025 at 5:16 AM
The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1
Reposted by Serge Mostowy
Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1
October 5, 2025 at 8:11 AM
Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
Reposted by Serge Mostowy
A great opportunity to attend the #Shigella meeting April 20-24, 2026! Abstract submissions are open! @shigellameeting.bsky.social #Microsky
External Event Grant awards of up to £750 are available for eligible members as a contribution towards the costs of registration, travel, and accommodation to attend an event beginning 01 Jan – 30 April 2026. Apply now before the deadline 01 Nov at 23:59: microb.io/ExternalEven...
External Event Grant
Login to apply
microb.io
September 27, 2025 at 12:03 PM
A great opportunity to attend the #Shigella meeting April 20-24, 2026! Abstract submissions are open! @shigellameeting.bsky.social #Microsky
Reposted by Serge Mostowy
Come and join us in Paris 2026 to talk all about Shigella!
September 18, 2025 at 12:46 PM
Come and join us in Paris 2026 to talk all about Shigella!
Reposted by Serge Mostowy
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home
www.shigella2026.conferences-pasteur.org/home
September 19, 2025 at 1:12 AM
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home
www.shigella2026.conferences-pasteur.org/home
Reposted by Serge Mostowy
We will be talking about our favorite microorganism #Shigella at the @shigellameeting.bsky.social in April 2026! 🦠 🧫
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
Happy International Microorganism Day! 🎉
Today, we are celebrating the tiny powerhouses that have a massive impact on our world. From the bacteria in our gut to the fungi that give us antibiotics, these incredible organisms are essential to life.
Let's make some noise for the microscopic!
Today, we are celebrating the tiny powerhouses that have a massive impact on our world. From the bacteria in our gut to the fungi that give us antibiotics, these incredible organisms are essential to life.
Let's make some noise for the microscopic!
September 17, 2025 at 3:21 PM
We will be talking about our favorite microorganism #Shigella at the @shigellameeting.bsky.social in April 2026! 🦠 🧫
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
@ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social
Reposted by Serge Mostowy
Why not follow our @shigellameeting.bsky.social starterpack of people who are speaking at and attending the conference - please message to be added to the starter pack if you're planning on coming or we haven't found you yet! go.bsky.app/6Vbwhjc
August 7, 2025 at 4:46 PM
Why not follow our @shigellameeting.bsky.social starterpack of people who are speaking at and attending the conference - please message to be added to the starter pack if you're planning on coming or we haven't found you yet! go.bsky.app/6Vbwhjc
Reposted by Serge Mostowy
💫Don't miss the N&V💫
📰Organoid models advance dysentery control.
By Sydney L. Miles & Serge Mostowy.
⬇️
www.nature.com/articles/s41...
📰Organoid models advance dysentery control.
By Sydney L. Miles & Serge Mostowy.
⬇️
www.nature.com/articles/s41...
Organoid models advance dysentery control - Nature Genetics
Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...
www.nature.com
June 23, 2025 at 2:14 PM
💫Don't miss the N&V💫
📰Organoid models advance dysentery control.
By Sydney L. Miles & Serge Mostowy.
⬇️
www.nature.com/articles/s41...
📰Organoid models advance dysentery control.
By Sydney L. Miles & Serge Mostowy.
⬇️
www.nature.com/articles/s41...
Reposted by Serge Mostowy
Last day of #SeptSRC begins with Marc Fivaz from reMYND with the most exciting septin advance of the year - a septin targeting compound that reverses Alzheimer’s symptoms in mice and patients
June 19, 2025 at 2:21 PM
Last day of #SeptSRC begins with Marc Fivaz from reMYND with the most exciting septin advance of the year - a septin targeting compound that reverses Alzheimer’s symptoms in mice and patients
Reposted by Serge Mostowy
Super exciting talk @ #SeptSRC by Friederike Arlt on septin autoantibodies linked to rare and inexplicable neurological disorder symptoms with cancer history. Possibly generated through immune response to cancer cells. So inspiring and motivating for future of septin use in medicine!
June 19, 2025 at 2:43 PM
Super exciting talk @ #SeptSRC by Friederike Arlt on septin autoantibodies linked to rare and inexplicable neurological disorder symptoms with cancer history. Possibly generated through immune response to cancer cells. So inspiring and motivating for future of septin use in medicine!
Reposted by Serge Mostowy
Back from coffee break with the latest septin fan and #SeptSRC newbie @nanigrotjahn.bsky.social on septins and mitochondria with amazing cryo ET and super resolution imaging.
Breathtaking views of septin filaments on mitochondria.
Breathtaking views of septin filaments on mitochondria.
June 17, 2025 at 3:42 PM
Back from coffee break with the latest septin fan and #SeptSRC newbie @nanigrotjahn.bsky.social on septins and mitochondria with amazing cryo ET and super resolution imaging.
Breathtaking views of septin filaments on mitochondria.
Breathtaking views of septin filaments on mitochondria.
Reposted by Serge Mostowy
#SeptSRC pathogenesis session continues with Serge “cageman” Mostowy @sergemostowylab.bsky.social presenting compelling new data on septins as a unique cytoskektal system that curtails Shigella infection.
June 15, 2025 at 11:31 PM
#SeptSRC pathogenesis session continues with Serge “cageman” Mostowy @sergemostowylab.bsky.social presenting compelling new data on septins as a unique cytoskektal system that curtails Shigella infection.
It is a great pleasure to think about your study and the impact it will have, congratulations
Thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for writing such a sharp and thoughtful editorial, which covers all the main points and potential caveats of our study published yesterday.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Organoid models advance dysentery control - Nature Genetics
Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...
www.nature.com
June 13, 2025 at 8:55 PM
It is a great pleasure to think about your study and the impact it will have, congratulations
Reposted by Serge Mostowy
Thrilled to share our work is finally out at @natgenet.nature.com ! rdcu.be/eqGgf
Combining a scalable human gut organoid model with TraDIS and statistical modeling, we mapped how Shigella colonizes the intestine at genome-wide resolution.
Combining a scalable human gut organoid model with TraDIS and statistical modeling, we mapped how Shigella colonizes the intestine at genome-wide resolution.
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
June 12, 2025 at 3:51 PM
Thrilled to share our work is finally out at @natgenet.nature.com ! rdcu.be/eqGgf
Combining a scalable human gut organoid model with TraDIS and statistical modeling, we mapped how Shigella colonizes the intestine at genome-wide resolution.
Combining a scalable human gut organoid model with TraDIS and statistical modeling, we mapped how Shigella colonizes the intestine at genome-wide resolution.
Congratulations on your transformative work
Finally thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for for highlighting our work with this cool editorial: www.nature.com/articles/s41...
Organoid models advance dysentery control - Nature Genetics
Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...
www.nature.com
June 12, 2025 at 6:25 PM
Congratulations on your transformative work