Khaled_Selim Lab
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selimlab.bsky.social
Khaled_Selim Lab
@selimlab.bsky.social
Microbiology | Cell Signaling | Structural Biology | Institute of Phototrophic Microbiology @hhu.de
https://www.phototrophic-microbiology.hhu.de/en/

Central Metabolism Coordination by #PII & #cdiAMP & #cdiGMP & #Ca2+ signaling #Cyanobacteria
Pinned
We discovered a new family of c-di-NMP receptors, widespread in bacteria & regulating🦠motility @pnas.org

A great collab. w/ @mygalperin.bsky.social @vikramalva.bsky.social @thethormannden.bsky.social

www.pnas.org/doi/10.1073/...

@hhu.de @cmfi.bsky.social
@sfb1381.bsky.social
@mibinet.bsky.social
Reposted by Khaled_Selim Lab
👉 A fascinating example of metabolic plasticity:

Three pathways feed the folate-dependent one carbon pool for growth and virulence of Listeria monocytogenes

doi.org/10.7554/eLif...

@elife.bsky.social #Listeria #folate
doi.org
November 26, 2025 at 7:20 AM
Reposted by Khaled_Selim Lab
Congrats to @chgjohnston.bsky.social , Andreani, Radicella et al.!
Elegant PNAS paper on the ComEC/ComFA/ComFC complex in bacterial transformation. AF3 predictions validated by clever mutagenesis. We tried for years to solve this by cryo-EM/crystallography - never succeeded.
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes | PNAS
Natural genetic transformation is a conserved mechanism of bacterial horizontal gene transfer, which is directed entirely by the recipient cell and...
www.pnas.org
November 25, 2025 at 9:41 PM
Reposted by Khaled_Selim Lab
Work I co-led with @jnoms.bsky.social is now online at
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.

www.sciencedirect.com/science/arti...
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to …
www.sciencedirect.com
November 25, 2025 at 9:10 PM
Reposted by Khaled_Selim Lab
AI model Helixer predicts eukaryotic genes ab initio, directly from a plain text FASTA file.

No RNA-seq.
No protein homology.
No repeats, hints, or curated evidence.

Raw genome → accurate gene models.
Deep learning + HMM, published in @natmethods.nature.com

www.nature.com/articles/s41...
Helixer: ab initio prediction of primary eukaryotic gene models combining deep learning and a hidden Markov model - Nature Methods
By leveraging both deep learning and hidden Markov models, Helixer achieves broad taxonomic coverage for ab initio gene annotation of eukaryotic genomes from fungi, plants, vertebrates and invertebrat...
www.nature.com
November 26, 2025 at 6:00 AM
Reposted by Khaled_Selim Lab
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Postdoc (m/f/d) in Endosymbiosis Research
karriere.hhu.de
November 25, 2025 at 11:21 AM
Reposted by Khaled_Selim Lab
Really happy to see the final version of this published in @isme-microbes.bsky.social. We show that production of and competition for biotin shapes S. aureus fitness in the context of nasal commensals doi.org/10.1093/isme...
Work lead by the amazing Kevser Bilici!
Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition
Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe
doi.org
November 24, 2025 at 5:54 PM
Reposted by Khaled_Selim Lab
November 24, 2025 at 7:51 AM
Reposted by Khaled_Selim Lab
🌍 World Antimicrobial Awareness Week 2025 🦠

Antimicrobial resistance threatens global health.
Unnecessary antibiotic use accelerates resistance and makes infections harder to treat.

Use antibiotics responsibly and help raise awareness.

Act now!

youtu.be/_Qy3aTKiVLE

#WWAW2025 #AMR #GoBlue
WAAW - World Antimicrobial Awareness Week
YouTube video by CMFI - Cluster of Excellence
youtu.be
November 19, 2025 at 1:30 PM
Reposted by Khaled_Selim Lab
Editorial: Society journals matter—supporting science through renewed commitment

Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues

academic.oup.com/microlife/ad...
Editorial: Society journals matter—supporting science through renewed commitment
Paul B Rainey, Puri López-García, Zeynep Ceren Karahan, Paul Williams, Stipan Jonjić, Kenneth N Timmis; Editorial: Society journals matter—supporting scien
academic.oup.com
November 22, 2025 at 6:35 PM
Reposted by Khaled_Selim Lab
The Microbiology Society is pleased to announce the winners of our 2026 Prizes! The winners will be awarded and deliver Prize Lectures at Annual Conference 2026 in Belfast from 13–16 April. Find out more about it: microb.io/PrizeWinners.... Meet the winners below. #Microbio26
November 19, 2025 at 2:58 PM
Reposted by Khaled_Selim Lab
We are back, soon!
The secrets of bacterial cell envelopes' our free online seminar series is due to resume in January 2026 after a long break.
Hosted by Georgina Benn and Syma Khalid- supported by the Microbiology Society. More details soon.
@microbiologysociety.org
Please spread the word
November 20, 2025 at 7:36 AM
Reposted by Khaled_Selim Lab
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet

🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain

📝Program and registration info: meetings.embo.org/event/26-bac...

👩‍🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social

#MicroSky
November 20, 2025 at 10:16 AM
Reposted by Khaled_Selim Lab
✨Opportunity to join the 🦁🦠 Predatory Bacteria lab!

My lab will move to University of Bern (CH) in April 2026 based on my #ERCStG.
Therefore, we are looking for:
-a PhD student (shorturl.at/mt0LR)
-a 50% Technical Assistant/Lab manager (shorturl.at/0IIKe)

🙏Thanks for sharing.
#MicroSky
November 19, 2025 at 7:01 PM
Reposted by Khaled_Selim Lab
Nachgefragt: Prof. Dr. Gert Bange im Interview
www.biospektrum.de/artikel/nach...

@bangebalcony.bsky.social
November 19, 2025 at 5:44 PM
Reposted by Khaled_Selim Lab
Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂

Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.

s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com
Prohibitin complexes associate with unique membrane microdomains in cells https://www.biorxiv.org/content/10.1101/2025.11.14.688579v1
November 17, 2025 at 12:22 AM
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis
www.nature.com/articles/s41...

Could be interesting for @spp2330.bsky.social
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis - Nature
Viral NblA accelerates the cyanophage infection cycle, directs degradation of the host phycobilisome and other proteins, and reduces host photosynthetic light-harvesting efficiency.
www.nature.com
November 18, 2025 at 7:36 PM
Metabolic Origin, Role and Fate of the Denaturant Guanidine

enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
November 18, 2025 at 6:46 PM
A small contribution from us & Edi Gerhardt @febsj.bsky.social

Highlighting the recent findings: Structure of the NifL-NifA complex controlling nitrogen fixation gene expression in Azotobacter

febs.onlinelibrary.wiley.com/doi/10.1111/...
@sfb1381.bsky.social @hhu.de @mibinet.bsky.social
FEBS Press
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth-promoting rhizobacteria play crucial roles in agric...
febs.onlinelibrary.wiley.com
November 17, 2025 at 4:55 PM
Proud to be part of @hhu.de ....
Still long way to go, but we're on it!
🎂6️⃣0️⃣ Happy Birthday, HHU! Heute vor 60 Jahren, am 16. November 1965, wurde die Universität Düsseldorf gegründet.
Seit 1988 heißt sie Heinrich-Heine-Universität. 1/3
November 16, 2025 at 9:16 AM
Reposted by Khaled_Selim Lab
🎂6️⃣0️⃣ Happy Birthday, HHU! Heute vor 60 Jahren, am 16. November 1965, wurde die Universität Düsseldorf gegründet.
Seit 1988 heißt sie Heinrich-Heine-Universität. 1/3
November 16, 2025 at 9:09 AM
Reposted by Khaled_Selim Lab
Hi EU 🌱 scientists, if you want to get Catch&Release 🎣vectors doi.org/10.1111/tpj.... hassle-free & pay only a small handling fee, please visits the so far little known great community resource to order DNA plasmids www.plasmids.eu kindly hosted by @dkfz.bsky.social & @telemanlab.bsky.social . Thx
doi.org
November 15, 2025 at 11:24 AM
Reposted by Khaled_Selim Lab
Pleased to share our review on S-layers with @bupbuse.bsky.social, Andriko von Kügelgen, and @tbharat-lab.bsky.social, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization. @mpi-bio-fml.bsky.social
November 13, 2025 at 9:16 PM
Reposted by Khaled_Selim Lab
What if even the core of bacterial nanomachines wasn’t static?

We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.

🔗 www.nature.com/articles/s41...

@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM