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Khaled_Selim Lab

@selimlab.bsky.social

280 followers 270 following 140 posts

Microbiology | Cell Signaling | Structural Biology | Institute of Phototrophic Microbiology @hhu.de https://www.phototrophic-microbiology.hhu.de/en/ Central Metabolism Coordination by #PII & #cdiAMP & #cdiGMP & #Ca2+ signaling #Cyanobacteria

www.phototrophic-microbiology.hhu.de

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Khaled_Selim Lab @selimlab.bsky.social · 25d

We discovered a new family of c-di-NMP receptors, widespread in bacteria & regulating🦠motility @pnas.org

A great collab. w/ @mygalperin.bsky.social @vikramalva.bsky.social @thethormannden.bsky.social

www.pnas.org/doi/10.1073/...

@hhu.de @cmfi.bsky.social
@sfb1381.bsky.social
@mibinet.bsky.social

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Reposted by Khaled_Selim Lab

Lori L. Burrows @dr-lori-burrows.bsky.social · 1d

New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...

Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics

Author summary Type IV pili enable Pseudomonas aeruginosa to attach to surfaces, move (twitch), and form biofilms. Pilus extension is powered by the motor protein PilB, which is regulated by other fac...

doi.org

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Reposted by Khaled_Selim Lab

SourjikLab @sourjik-lab.bsky.social · 18h

Happy to share as my first Bluesky post: Our newest paper describing a beautiful example of surprizing evolutionary innovation: Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal www.embopress.org/doi/full/10....

Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli | The EMBO Journal

imageimageChemotaxis receptors typically mediate biased movement of motile bacteria in environmental gradients by controlling rotation of the flagellar motor. This study identifies a chemotaxis recept...

www.embopress.org

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Reposted by Khaled_Selim Lab

Antimicrobial resistance #AMR @antimicrobial.bsky.social · 1d

WHO reports 1 in 6 bacterial infections worldwide are antibiotic-resistant, with resistance rising sharply since 2018. Gram-negative bacteria like E. coli and K. pneumoniae pose the biggest threat. Action on #AMR surveillance and responsible antibiotic use is needed.

www.who.int/news/item/13...

WHO warns of widespread resistance to common antibiotics worldwide

One in six laboratory-confirmed bacterial infections causing common infections in people worldwide in 2023 were resistant to antibiotic treatments, according to a new World Health Organization (WHO) r...

www.who.int

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Reposted by Khaled_Selim Lab

Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 1d

Any structural biologists who want some fun? Try building mirror folds. When you’re building them you seriously innately feel like this is “off” but they do exist! When I looked at some of these datasets and deciding which way to turn in Coot it was so offsetting www.biorxiv.org/content/10.1...

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Reposted by Khaled_Selim Lab

Susan Schlimpert @s-lab.bsky.social · 1d

We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.

Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...

Beyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training Partnership

Join us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats.

biodtp.norwichresearchpark.ac.uk

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Khaled_Selim Lab @selimlab.bsky.social · 3d

Is it your hand? 😜
Or your kid? - I wanna go back in time and be young again 😂

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Khaled_Selim Lab @selimlab.bsky.social · 3d

I know this place @frunzkelab.bsky.social ;-)

I hope you had fun...

Reposted by Khaled_Selim Lab

Ákos T Kovács @evolvedbiofilm.bsky.social · 3d

Extracellular ATP is an environmental cue in bacteria

@cp-cellreports.bsky.social

www.cell.com/cell-reports...

Extracellular ATP is an environmental cue in bacteria

Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the tra...

www.cell.com

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Reposted by Khaled_Selim Lab

Ben Long @botbml.bsky.social · 3d

Cyanophycinase is required for heterotrophy in cyanobacteria - Journal of Biological Chemistry www.jbc.org/article/S002...

Cyanophycinase is required for heterotrophy in cyanobacteria

Cyanophycin is a biopolymer of arginine and aspartate, and it is found in various prokaryotes. Two key enzymes of cyanophycin metabolism are cyanophycin synthase (CphA) producing cyanophycin, and cyan...

www.jbc.org

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Reposted by Khaled_Selim Lab

ETH Zurich @ethz.ch · 4d

All cells – from mammalian cells to microbes – can follow different biological paths. Whether they grow and divide, specialise, age or die depends on the pathway they take. New findings by researchers at ETH Zurich could help influence a cell’s decisions to target diseases such as cancer.

Protein condensates determine a cell’s fate

Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.

ethz.ch

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Reposted by Khaled_Selim Lab

GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 6d

Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026
lnkd.in/dgsW4c3

Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026

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Khaled_Selim Lab @selimlab.bsky.social · 6d

Plz re-post

A wonderful place to be...
Come and join us a group leader position in „Phage Biology & Biotechnology“.

www.fz-juelich.de/de/karriere/...
Get in touch with @frunzkelab.bsky.social for more information

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Khaled_Selim Lab @selimlab.bsky.social · 7d

This add on to the functional catalog of #cdiAMP by showing it's involvement in ROS balance, photosyn., motility & proteome stability to regulate day-night switches in #cyano

part of this work was done by my former PhD, Michael Haffner @cmfi.bsky.social and some support by @sfb1381.bsky.social ...

Khaled_Selim Lab @selimlab.bsky.social · 7d

A bit late 🙃 but happy to share our recent findings on #cdiAMP signaling in controlling #cyanobacteria #diurnal rhythm in @cp-iscience.bsky.social

www.cell.com/iscience/ful...

#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade

Biological sciences; Biochemistry; Microbiology; PII-like protein SbtB; c-di-AMP signaling; Cyanobacteria; Carbon/Nitrogen metabolism; Redox imbalance; Photosynthesis; Reactive oxygen species (ROS); C...

www.cell.com

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Reposted by Khaled_Selim Lab

Patricia Bernal @pbernalt6ss.bsky.social · 8d

Our paper, describing how the T6SSs of P. putida shape the tomato rhizosphere, is now in its final format in @isme-microbes.bsky.social ISME Communications. If you'd like to learn more, here is a thread (1/11) or read the Article doi.org/10.1093/isme....

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Khaled_Selim Lab @selimlab.bsky.social · 8d

He found another one of a bacterium with mitochondrial dysfunction
I don't know if I should laugh 😂 or cry 😭 ....

@mdpiopenaccess.bsky.social

www.mdpi.com/2079-6382/14...

Reposted by Khaled_Selim Lab

Molecular Microbiology @molmicrounihoh.bsky.social · 8d

Humans began travelling into space in 1961 with single orbits of the Earth. Now Bacillus subtilis!

👉

www.nature.com/articles/s41...

#subtiwiki

Thank you @joergstuelke.bsky.social for the reading recommendation!

Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight - npj Microgravity

npj Microgravity - Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight

www.nature.com

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Khaled_Selim Lab @selimlab.bsky.social · 8d

Here's the original comment:

pubpeer.com/publications...

PubPeer - Nanotechnology-Enhanced Orthopaedic Surgery

There are comments on PubPeer for publication: Nanotechnology-Enhanced Orthopaedic Surgery (2024)

pubpeer.com

Khaled_Selim Lab @selimlab.bsky.social · 8d

Bacterial 🦠 mitochondria 🙈 .... What a shit 😅

@sholtodavid.bsky.social pointed in X for an "unreviewed" article with status officially reviewed in @mdpiopenaccess.bsky.social

Maybe it's AI generated with no efforts from authors, editors or reviewers to go through it?

www.mdpi.com/2624-845X/5/...

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Khaled_Selim Lab @selimlab.bsky.social · 9d

Very interesting work for maintaining synthetic microbial consortia

www.nature.com/articles/s41...

@mibinet.bsky.social

Long-term homeostasis in microbial consortia via auxotrophic cross-feeding - Nature Communications

Synthetic microbial consortia are collections of strains which can segregate metabolic tasks for efficient use in biomaterials, biomanufacturing, and biotherapeutics. Here, the authors present a method to maintain and tune the ratio of two co-cultured bacterial strains via growth medium manipulation.

www.nature.com

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Khaled_Selim Lab @selimlab.bsky.social · 9d

Synthetic Horizontal Gene Transfer for Ecosystem Restoration

www.biorxiv.org/content/10.1...

Synthetic Horizontal Gene Transfer for Ecosystem Restoration

Restoring endangered ecosystems has become a pressing issue as the effects of global warming continue to harm existing communities. Over the last decade, several studies have suggested the use of synt...

www.biorxiv.org

Reposted by Khaled_Selim Lab

Daumann Lab @daumannl.bsky.social · 11d

Video compilation from our #türenauf mit der Maus Tag today! #outreach #chemsky @hhu.de @sophieguti.bsky.social @joguti.bsky.social @markussuta.bsky.social @chemiehhu.bsky.social

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Reposted by Khaled_Selim Lab

Tung Le @tunglejic.bsky.social · 11d

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

John Innes Centre @johninnescentre.bsky.social · 11d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...