Saskia Freytag
@saskiafreytag.bsky.social
Lab Head at the WEHI and the Brain Cancer Center by CB4BC. BioinfoMagician using computational biology, spatial and single cell omics so that one day no lives will be lost to brain cancer.
Reposted by Saskia Freytag
Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas.
🔗 www.wehi.edu.au/news/world-f...
🔗 www.wehi.edu.au/news/world-f...
August 22, 2025 at 10:31 PM
Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas.
🔗 www.wehi.edu.au/news/world-f...
🔗 www.wehi.edu.au/news/world-f...
Reposted by Saskia Freytag
A landmark research milestone, from a brilliant collaborative team, published in @natmed.nature.com
🔗 www.nature.com/articles/s41...
@sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social
🔗 www.nature.com/articles/s41...
@sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial - Nature Medicine
This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture bef...
www.nature.com
August 22, 2025 at 10:31 PM
A landmark research milestone, from a brilliant collaborative team, published in @natmed.nature.com
🔗 www.nature.com/articles/s41...
@sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social
🔗 www.nature.com/articles/s41...
@sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social
Reposted by Saskia Freytag
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma
Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...
rdcu.be
January 8, 2025 at 5:13 PM
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵
Reposted by Saskia Freytag
Brain-wide neuronal circuit connectome of human glioblastoma www.nature.com/articles/s41...
Brain-wide neuronal circuit connectome of human glioblastoma - Nature
Nature - Brain-wide neuronal circuit connectome of human glioblastoma
www.nature.com
January 17, 2025 at 7:33 AM
Brain-wide neuronal circuit connectome of human glioblastoma www.nature.com/articles/s41...
New review article from the lab discusses everything GBM tumor microenvironment: tech (spatial transcriptomic, metabolomics and proteomics), biology and implications for the clinic.
@jimwhittle.bsky.social
@sarahbest.bsky.social
www.sciencedirect.com/science/arti...
@jimwhittle.bsky.social
@sarahbest.bsky.social
www.sciencedirect.com/science/arti...
January 14, 2025 at 12:44 AM
New review article from the lab discusses everything GBM tumor microenvironment: tech (spatial transcriptomic, metabolomics and proteomics), biology and implications for the clinic.
@jimwhittle.bsky.social
@sarahbest.bsky.social
www.sciencedirect.com/science/arti...
@jimwhittle.bsky.social
@sarahbest.bsky.social
www.sciencedirect.com/science/arti...
New work from the lab on comparing patient-derived GBM organoids & spheroids. TLRD: Surprisingly very similar across genetic, transcriptomics and epigenetic levels!
Now on BioRxiv: we explored patient-derived GBM organoids & spheroids generated from the same resected tissue. Critically, both models maintain tumor cell composition & heterogeneity, with comparable tissue resemblance across data modalities (1/4)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 14, 2025 at 12:29 AM
New work from the lab on comparing patient-derived GBM organoids & spheroids. TLRD: Surprisingly very similar across genetic, transcriptomics and epigenetic levels!
Beautiful collaboration! Congratulations.
Thrilled to announce a new paper from former Molecular Medicine PhD student, Kristen Kay, just published in JCI - also happy to bring the lab success chain to this platform 🕺🏻! She is not going to Houston, but I will be presenting a poster on her behalf at #SNO2024 pubmed.ncbi.nlm.nih.gov/39561012/
November 20, 2024 at 2:24 AM
Beautiful collaboration! Congratulations.