Sambhawa Priya
@sambhawa.bsky.social
Chicago DFI Fellow at UChicago | host-microbiome interactions, machine learning | sambhawapriya.netlify.app
It was an absolute pleasure working together with the brilliant first author, Dr. Karolina Sjöberg Jabbar, and the entire team during my postdoctoral work in the Xavier lab at the Broad Institute. Grateful to see this work out in the world!
November 21, 2025 at 11:01 PM
It was an absolute pleasure working together with the brilliant first author, Dr. Karolina Sjöberg Jabbar, and the entire team during my postdoctoral work in the Xavier lab at the Broad Institute. Grateful to see this work out in the world!
Antiretrovirals also shaped gut ecology. In Uganda & Botswana, efavirenz was linked to Prevotella loss. Computational & in vitro experiments showed that efavirenz may inhibit bacterial reverse transcriptases involved in antiphage defense, disrupting non-Western Prevotella-rich ecosystems.
November 21, 2025 at 11:01 PM
Antiretrovirals also shaped gut ecology. In Uganda & Botswana, efavirenz was linked to Prevotella loss. Computational & in vitro experiments showed that efavirenz may inhibit bacterial reverse transcriptases involved in antiphage defense, disrupting non-Western Prevotella-rich ecosystems.
Although taxa varied by region, shifts in microbial functions were shared across HIV cohorts: reduced carbohydrate-utilization and motility/sporulation genes, and enriched mannose PTS transporters—pointing to a shift toward mucosal colonizers in an inflamed gut.
November 21, 2025 at 11:01 PM
Although taxa varied by region, shifts in microbial functions were shared across HIV cohorts: reduced carbohydrate-utilization and motility/sporulation genes, and enriched mannose PTS transporters—pointing to a shift toward mucosal colonizers in an inflamed gut.
At taxonomic level, we observed both geography-specific shifts (e.g. Uganda→Botswana→US gradient in Prevotella) as well as shared alterations (e.g. depletion of Faecalibacterium prausnitzii across cohorts with HIV), which also helped predict HIV status across sites.
November 21, 2025 at 11:01 PM
At taxonomic level, we observed both geography-specific shifts (e.g. Uganda→Botswana→US gradient in Prevotella) as well as shared alterations (e.g. depletion of Faecalibacterium prausnitzii across cohorts with HIV), which also helped predict HIV status across sites.
Reposted by Sambhawa Priya
We’re thrilled that our first paper on the Human Microbiome Compendium, an integrated dataset of over 168,000 uniformly processed human gut microbiome samples, is officially out today in Cell! @richabdill.com @blekhman.bsky.social www.cell.com/cell/fulltex...
Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human
gut microbiome 16S samples, built with the integrated data from hundreds of independent
projects. The compendium is us...
www.cell.com
January 22, 2025 at 5:58 PM