Our findings reveal a general mechanism of biomolecular stability--compensatory flexibility--that we predict is widely used by structured biopolymers. This conceptual breakthrough allows the design of mutations and ligands that can disrupt or engineer biomolecular function. 5/5

We found that the stem-loop folds via two distinct pathways, each defined by a different loop structure.
By tuning its flexibility, the RNA can favor either rapid folding or resistance to unfolding—an adaptive strategy for robust structural stability. 4/5

Using a carbon nanotube–based single-molecule field-effect transistor (smFET), we recorded the folding and unfolding of an individual UUCG stem-loop at microsecond time resolution, revealing conformations and kinetic pathways that ensemble methods cannot resolve. 3/5

An excellent collaboration with the labs of Ken Shepard and Colin Nuckolls, led by @ssjang.bsky.social, @korakray.bsky.social, and David Lynall! 2/5

I said I would! 🤣

He also calls on US colleges and universities to stand together against the “anti-intellectuals [. . .] undermining [. . .] the ability of teachers and researchers to work without political micromanagement in the pursuit of truth, even when these truths are unpopular.” 5/5

“At no point did our leadership concede any of these essential principles, which is surely why Columbia has been under Department of Justice investigation “for harboring and concealing illegal aliens on its campus.” 4/5

“Nor would we collaborate with government agents intent on deporting our students and faculty members simply because they exercised their First Amendment rights.” 3/5

“Columbia would not allow any government to deny professors their rightful role in personnel decisions or to dictate the content of our curricula.” 2/5

Thanks, Jamie! Tell me about it…

Thanks for the vote of confidence, Ed!

As always, thanks for the support, Heather! I hope all is well (or as well as it can be!) in your neck of the woods!