Ruben Gonzalez
@rubenlgonzalez.bsky.social
Dean of Science, Professor of Chemistry, and Professor of Physiology & Cellular Biophysics at Columbia University | Single-Molecule Biophysics, Structural Biology, and Biochemistry | Diversity, Equity, and Inclusion in STEM
New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
July 31, 2025 at 2:27 AM
New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
Check out group member Meghna Maiti’s poster at #RNA2025! She’s presenting new findings on how frameshift-suppressor tRNAs exhibit altered dynamics in the ribosomal A site that modulate translocation and +1 frameshifting. Friday, 8–10 PM PT — she’s at P2-492!
May 30, 2025 at 11:07 PM
Check out group member Meghna Maiti’s poster at #RNA2025! She’s presenting new findings on how frameshift-suppressor tRNAs exhibit altered dynamics in the ribosomal A site that modulate translocation and +1 frameshifting. Friday, 8–10 PM PT — she’s at P2-492!
A blast from the past! The Gonzalez Group, circa 2008, celebrating our first publication! Check out much, much younger versions of, from left to right, Pallav Kosuri, yours truly, Sam Sternberg, Mike Englander, @jingyifei.bsky.social, Daniel MacDougall, Margaret Elvekrog, and Subasree Das!
May 30, 2025 at 8:50 PM
A blast from the past! The Gonzalez Group, circa 2008, celebrating our first publication! Check out much, much younger versions of, from left to right, Pallav Kosuri, yours truly, Sam Sternberg, Mike Englander, @jingyifei.bsky.social, Daniel MacDougall, Margaret Elvekrog, and Subasree Das!
Excited to share that group member Riley Gentry will present a talk at #RNA2025 tomorrow! He’ll reveal how PIC-bound eIFs collaborate to drive mRNA loading during translation initiation. Don’t miss “The mechanism of mRNA activation” at 9 AM in the Translation Mechanisms plenary.
May 30, 2025 at 3:43 AM
Excited to share that group member Riley Gentry will present a talk at #RNA2025 tomorrow! He’ll reveal how PIC-bound eIFs collaborate to drive mRNA loading during translation initiation. Don’t miss “The mechanism of mRNA activation” at 9 AM in the Translation Mechanisms plenary.
Thanks to #JeffreyKieft for an excellent SCI-Talk Seminar visit to #NYSBC! A great day of science, friends, and potential collaborations!
December 17, 2024 at 9:35 PM
Thanks to #JeffreyKieft for an excellent SCI-Talk Seminar visit to #NYSBC! A great day of science, friends, and potential collaborations!
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
December 11, 2024 at 9:35 PM
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...