CEO’s past is kind of amusing as are operating loss as a percentage of revenue. www.breakingviews.com/columns/cons...

it's horrifying, but also rather astonishing how quickly we have become accustomed to, nah, that's not seriously unexpected. Also would expect more movement on 10yr if that were the explanation

This is notable: traditional flu vaccines generate modest T-cell immunity. The more robust cellular responses seen here could matter for durability and breadth of protection, especially in drift-heavy years.

The primary question:
Can an mRNA flu vaccine match or outperform our current vaccines at preventing lab-confirmed influenza illness?
The answer is an emphatic yes. Look at the separation of those curves

It’s wild that rye’s domesticating itself might have led to witch trials (rye is susceptible to ergot, and ergot poisoning caused mass outbreaks of hallucinations, convulsions, loss of extremities. And areas heavy in rye consumption and rain match up nicely with witch trials)

Yep - they used to get a majority of all revenue from Christmas sales of graphics chips.

Source for image: nantucketcurrent.com. Did not happen at Coatue beach FWIW

Similar to the fracking bubble (depreciation) and telco (circular rev, vendor financing). Cracks obvious, but these things go forever until they collapse under own weight. For telco, took realization demand growth far slower than assumed. Fracking when bigger and bigger capex needed to grow output.

Number of US deaths from flu usually between 10k and 50K annually, with serious skew during bad years. But this is almost certainly a big undercount - you are more than six times more likely to have a heart attack when you have the flu. www.nejm.org/doi/full/10....

Ok maybe leavened with some Gericault

In case anyone wondering Novo’s EVOKE trial to see if sema slows down Alzheimer’s is supposed to read out by year end.

Drug company - we have developed a drug that reduces nine of the top ten causes of death and may slow dementia. Markets - great you are worth $200bn

Tech company - we have a commoditized research assistant that makes lots of errors and requires unfashionable capex. Markets - you are worth $1tr

Huh. Mrs C disagrees with my color categorization with blue and green and I guess she has a point (68% blue here). I guess I now understand how in many languages there is only one word for both green and blue

Keep on saying this but developing vaccines against latent viruses and you will see some really interesting declines in various autoimmune diseases and a few forms of cancer. (That is if people aren’t idiots and actually get their kids vaccinated)