Rene Sugar
@renesugar.bsky.social
Extracellular vesicles mediate antibody-resistant transmission of #SARSCoV2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2 - Cell Discovery
Cell Discovery - Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2
www.nature.com
November 29, 2025 at 4:27 PM
Extracellular vesicles mediate antibody-resistant transmission of #SARSCoV2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.mdpi.com/1999-4915/17...
"Our data suggest that EVs released during the HAdV-E4 infection may serve as vehicles for non-lytic viral dissemination and highlight their possible role in intra-host dissemination."
"Our data suggest that EVs released during the HAdV-E4 infection may serve as vehicles for non-lytic viral dissemination and highlight their possible role in intra-host dissemination."
www.mdpi.com
November 29, 2025 at 4:18 PM
www.mdpi.com/1999-4915/17...
"Our data suggest that EVs released during the HAdV-E4 infection may serve as vehicles for non-lytic viral dissemination and highlight their possible role in intra-host dissemination."
"Our data suggest that EVs released during the HAdV-E4 infection may serve as vehicles for non-lytic viral dissemination and highlight their possible role in intra-host dissemination."
www.mdpi.com/1999-4915/17...
"Notably, AdV-EVs contained viral genomic DNA and could initiate productive infection upon delivery to naïve cells in the absence of detectable viral particles."
"Notably, AdV-EVs contained viral genomic DNA and could initiate productive infection upon delivery to naïve cells in the absence of detectable viral particles."
www.mdpi.com
November 29, 2025 at 4:18 PM
www.mdpi.com/1999-4915/17...
"Notably, AdV-EVs contained viral genomic DNA and could initiate productive infection upon delivery to naïve cells in the absence of detectable viral particles."
"Notably, AdV-EVs contained viral genomic DNA and could initiate productive infection upon delivery to naïve cells in the absence of detectable viral particles."
The drugs you mentioned affect folate and other vitamins like B12 whose deficiencies cause serious problems.
Might have tripped a borderline deficiency.
eg. Neuropsychiatric Disorders Associated With Vitamin B12 Deficiency: An Autobiographical Case Report
pmc.ncbi.nlm.nih.gov/articles/PMC...
Might have tripped a borderline deficiency.
eg. Neuropsychiatric Disorders Associated With Vitamin B12 Deficiency: An Autobiographical Case Report
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 29, 2025 at 1:18 AM
The drugs you mentioned affect folate and other vitamins like B12 whose deficiencies cause serious problems.
Might have tripped a borderline deficiency.
eg. Neuropsychiatric Disorders Associated With Vitamin B12 Deficiency: An Autobiographical Case Report
pmc.ncbi.nlm.nih.gov/articles/PMC...
Might have tripped a borderline deficiency.
eg. Neuropsychiatric Disorders Associated With Vitamin B12 Deficiency: An Autobiographical Case Report
pmc.ncbi.nlm.nih.gov/articles/PMC...
Methemoglobinemia in a 28-year-old woman treated with dapsone
www.cmaj.ca/content/194/...
Evaluation of effect of some corticosteroids on glucose-6-phosphate dehydrogenase and comparative study of antioxidant enzyme activities
www.tandfonline.com/doi/pdf/10.1...
www.cmaj.ca/content/194/...
Evaluation of effect of some corticosteroids on glucose-6-phosphate dehydrogenase and comparative study of antioxidant enzyme activities
www.tandfonline.com/doi/pdf/10.1...
Methemoglobinemia in a 28-year-old woman treated with dapsone
KEY POINTS
A 28-year-old woman presented to the emergency department with a 4-day history of shortness of breath and fatigue.
The patient had received a diagnosis of immunoglobulin A (IgA) nephropath...
www.cmaj.ca
November 29, 2025 at 1:04 AM
Methemoglobinemia in a 28-year-old woman treated with dapsone
www.cmaj.ca/content/194/...
Evaluation of effect of some corticosteroids on glucose-6-phosphate dehydrogenase and comparative study of antioxidant enzyme activities
www.tandfonline.com/doi/pdf/10.1...
www.cmaj.ca/content/194/...
Evaluation of effect of some corticosteroids on glucose-6-phosphate dehydrogenase and comparative study of antioxidant enzyme activities
www.tandfonline.com/doi/pdf/10.1...
Your doctor tested for Glucose-6-Phosphate Dehydrogenase Deficiency?
Methemoglobinemia
emcrit.org/ibcc/methemo...
Glucose-6-Phosphate Dehydrogenase Deficiency
www.ncbi.nlm.nih.gov/books/NBK470...
g6pddf.org/g6pd-screeni...
G6PD Test
www.ultalabtests.com/test/glucose...
Methemoglobinemia
emcrit.org/ibcc/methemo...
Glucose-6-Phosphate Dehydrogenase Deficiency
www.ncbi.nlm.nih.gov/books/NBK470...
g6pddf.org/g6pd-screeni...
G6PD Test
www.ultalabtests.com/test/glucose...
Methemoglobinemia
CONTENTS Epidemiology Clinical presentation Diagnosis Treatment Treatment for most patients Treatment in G6PD deficiency Treatment in pregnancy Physiology medication triggers Local anesthetics: Benzoc...
emcrit.org
November 29, 2025 at 1:04 AM
Your doctor tested for Glucose-6-Phosphate Dehydrogenase Deficiency?
Methemoglobinemia
emcrit.org/ibcc/methemo...
Glucose-6-Phosphate Dehydrogenase Deficiency
www.ncbi.nlm.nih.gov/books/NBK470...
g6pddf.org/g6pd-screeni...
G6PD Test
www.ultalabtests.com/test/glucose...
Methemoglobinemia
emcrit.org/ibcc/methemo...
Glucose-6-Phosphate Dehydrogenase Deficiency
www.ncbi.nlm.nih.gov/books/NBK470...
g6pddf.org/g6pd-screeni...
G6PD Test
www.ultalabtests.com/test/glucose...
Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral mucosal disease
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral mucosal disease
Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed t…
www.sciencedirect.com
November 28, 2025 at 5:34 PM
Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral mucosal disease
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
#SARSCoV2 causes gastric damage: structural and ultrastructural evaluation
pubmed.ncbi.nlm.nih.gov/40542875/
pubmed.ncbi.nlm.nih.gov/40542875/
SARS-CoV-2 causes gastric damage: structural and ultrastructural evaluation - PubMed
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infects the gastrointestinal tract; however, its effects on the stomach and underlying mechanisms remain unknown. The presence of ACE2 (angiotensin-converting enzyme 2) receptors in the gastric mucosa suggests that the stomach is vulnerabl …
pubmed.ncbi.nlm.nih.gov
November 28, 2025 at 5:34 PM
#SARSCoV2 causes gastric damage: structural and ultrastructural evaluation
pubmed.ncbi.nlm.nih.gov/40542875/
pubmed.ncbi.nlm.nih.gov/40542875/
www.nature.com/articles/s41...
"The overall clinical performance of calprotectin in the distinction between bacterial and viral respiratory infections, including mycoplasma was greater than performance of PCT and HBP."
"The overall clinical performance of calprotectin in the distinction between bacterial and viral respiratory infections, including mycoplasma was greater than performance of PCT and HBP."
Calprotectin, a new biomarker for diagnosis of acute respiratory infections - Scientific Reports
Scientific Reports - Calprotectin, a new biomarker for diagnosis of acute respiratory infections
www.nature.com
November 28, 2025 at 5:08 PM
www.nature.com/articles/s41...
"The overall clinical performance of calprotectin in the distinction between bacterial and viral respiratory infections, including mycoplasma was greater than performance of PCT and HBP."
"The overall clinical performance of calprotectin in the distinction between bacterial and viral respiratory infections, including mycoplasma was greater than performance of PCT and HBP."
www.nature.com/articles/s41...
"PCT was significantly elevated in patients with bacterial pneumonia compared to viral infections but not in streptococcal tonsillitis or mycoplasma caused infections."
"HBP was not able to distinguish between bacterial and viral causes of infections."
"PCT was significantly elevated in patients with bacterial pneumonia compared to viral infections but not in streptococcal tonsillitis or mycoplasma caused infections."
"HBP was not able to distinguish between bacterial and viral causes of infections."
Calprotectin, a new biomarker for diagnosis of acute respiratory infections - Scientific Reports
Scientific Reports - Calprotectin, a new biomarker for diagnosis of acute respiratory infections
www.nature.com
November 28, 2025 at 5:08 PM
www.nature.com/articles/s41...
"PCT was significantly elevated in patients with bacterial pneumonia compared to viral infections but not in streptococcal tonsillitis or mycoplasma caused infections."
"HBP was not able to distinguish between bacterial and viral causes of infections."
"PCT was significantly elevated in patients with bacterial pneumonia compared to viral infections but not in streptococcal tonsillitis or mycoplasma caused infections."
"HBP was not able to distinguish between bacterial and viral causes of infections."
www.nature.com/articles/s41...
"Calprotectin was significantly increased in patients with bacterial infections; bacterial pneumonia, mycoplasma pneumonia and streptococcal tonsillitis compared with viral infections."
"Calprotectin was significantly increased in patients with bacterial infections; bacterial pneumonia, mycoplasma pneumonia and streptococcal tonsillitis compared with viral infections."
Calprotectin, a new biomarker for diagnosis of acute respiratory infections - Scientific Reports
Scientific Reports - Calprotectin, a new biomarker for diagnosis of acute respiratory infections
www.nature.com
November 28, 2025 at 5:08 PM
www.nature.com/articles/s41...
"Calprotectin was significantly increased in patients with bacterial infections; bacterial pneumonia, mycoplasma pneumonia and streptococcal tonsillitis compared with viral infections."
"Calprotectin was significantly increased in patients with bacterial infections; bacterial pneumonia, mycoplasma pneumonia and streptococcal tonsillitis compared with viral infections."
www.nature.com/articles/s41...
"All biomarkers were elevated in bacterial and viral infections compared to healthy controls."
"All biomarkers were elevated in bacterial and viral infections compared to healthy controls."
Calprotectin, a new biomarker for diagnosis of acute respiratory infections - Scientific Reports
Scientific Reports - Calprotectin, a new biomarker for diagnosis of acute respiratory infections
www.nature.com
November 28, 2025 at 5:08 PM
www.nature.com/articles/s41...
"All biomarkers were elevated in bacterial and viral infections compared to healthy controls."
"All biomarkers were elevated in bacterial and viral infections compared to healthy controls."
www.nature.com/articles/s41...
"We investigated the diagnostic performance of calprotectin in respiratory tract infections and compared it with the performance of heparin binding protein (HBP) and procalcitonin (PCT)."
"We investigated the diagnostic performance of calprotectin in respiratory tract infections and compared it with the performance of heparin binding protein (HBP) and procalcitonin (PCT)."
Calprotectin, a new biomarker for diagnosis of acute respiratory infections - Scientific Reports
Scientific Reports - Calprotectin, a new biomarker for diagnosis of acute respiratory infections
www.nature.com
November 28, 2025 at 5:08 PM
www.nature.com/articles/s41...
"We investigated the diagnostic performance of calprotectin in respiratory tract infections and compared it with the performance of heparin binding protein (HBP) and procalcitonin (PCT)."
"We investigated the diagnostic performance of calprotectin in respiratory tract infections and compared it with the performance of heparin binding protein (HBP) and procalcitonin (PCT)."
Riboflavin
ods.od.nih.gov/factsheets/R...
"Moreover, ultraviolet and visible light can rapidly inactivate riboflavin and its derivatives."
ods.od.nih.gov/factsheets/R...
"Moreover, ultraviolet and visible light can rapidly inactivate riboflavin and its derivatives."
Office of Dietary Supplements - Riboflavin
Riboflavin (Vit B2) overview for health professionals. Research health effects, dosing, sources, deficiency, side effects, and interactions here.
ods.od.nih.gov
November 27, 2025 at 6:48 PM
Riboflavin
ods.od.nih.gov/factsheets/R...
"Moreover, ultraviolet and visible light can rapidly inactivate riboflavin and its derivatives."
ods.od.nih.gov/factsheets/R...
"Moreover, ultraviolet and visible light can rapidly inactivate riboflavin and its derivatives."
"Mirasol PRT (PRT) treatment uses riboflavin in the presence of UV light (280–360 nm) to inactivate pathogens and leucocytes in blood products."
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mirasol Pathogen Reduction Technology® treatment does not affect acute lung injury in a two-event in vivo model caused by stored blood components
Mirasol Pathogen Reduction Technology® (PRT) treatment uses riboflavin and UV light to inactivate pathogens in blood components. Neutrophil [polymorphonuclear cells (PMN)] priming activity accumulates during routine storage of cellular blood ...
pmc.ncbi.nlm.nih.gov
November 27, 2025 at 6:48 PM
"Mirasol PRT (PRT) treatment uses riboflavin in the presence of UV light (280–360 nm) to inactivate pathogens and leucocytes in blood products."
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Mirasol
Reduce the pathogen load in donated blood and inactivate residual white blood cells
terumobct.com
November 27, 2025 at 6:48 PM
Repurposing of FDA-approved drugs as potential DNA Gyrase Inhibitors
www.researchgate.net/publication/...
www.researchgate.net/publication/...
(PDF) Repurposing of FDA-approved drugs as potential DNA Gyrase Inhibitors
PDF | Traditional drugs fail to treat bacterial infections due to the increasing development of resistance in bacteria toward the available antibiotics.... | Find, read and cite all the research you n...
www.researchgate.net
November 27, 2025 at 6:48 PM
Repurposing of FDA-approved drugs as potential DNA Gyrase Inhibitors
www.researchgate.net/publication/...
www.researchgate.net/publication/...
pubmed.ncbi.nlm.nih.gov/32311760/
"The data suggest that the process would be effective in reducing the theoretical risk of transfusion transmitted #SARSCoV2."
"The data suggest that the process would be effective in reducing the theoretical risk of transfusion transmitted #SARSCoV2."
Inactivation of severe acute respiratory syndrome coronavirus 2 in plasma and platelet products using a riboflavin and ultraviolet light-based photochemical treatment - PubMed
Riboflavin and UV light effectively reduced the titre of SARS-CoV-2 in both plasma and platelet products to below the limit of detection in tissue culture. The data suggest that the process would be effective in reducing the theoretical risk of transfusion transmitted SARS-CoV-2.
pubmed.ncbi.nlm.nih.gov
November 27, 2025 at 6:48 PM
pubmed.ncbi.nlm.nih.gov/32311760/
"The data suggest that the process would be effective in reducing the theoretical risk of transfusion transmitted #SARSCoV2."
"The data suggest that the process would be effective in reducing the theoretical risk of transfusion transmitted #SARSCoV2."