@rapidrobby.bsky.social
Reposted
Using a new genetically-encoded voltage indicator in an all-optical approach to measure synaptic plasticity in awake behaving mice. Great work by @jacquescarolan.bsky.social and colleagues. Check out www.nature.com/articles/s41...
All-optical voltage interrogation for probing synaptic plasticity in vivo - Nature Communications
Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.
www.nature.com
October 4, 2025 at 2:15 AM
Using a new genetically-encoded voltage indicator in an all-optical approach to measure synaptic plasticity in awake behaving mice. Great work by @jacquescarolan.bsky.social and colleagues. Check out www.nature.com/articles/s41...
Reposted
A far-red dopamine sensor unlocks multiplex views of in vivo neuromodulation — a Tools of the Trade article by Yu Zheng
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
A far-red dopamine sensor unlocks multiplex views of in vivo neuromodulation - Nature Reviews Neuroscience
In this Tools of the Trade article, Yu Zheng describes the design of a far-red dopamine sensor that enables the simultaneous monitoring of multiple neurotransmitters in the brain.
www.nature.com
September 11, 2025 at 1:04 PM
A far-red dopamine sensor unlocks multiplex views of in vivo neuromodulation — a Tools of the Trade article by Yu Zheng
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Reposted
Cocaine-activated ion channels engineered to break the loop of addiction in rats.
These ion channels have been used to engineer neural circuits in rats to respond to cocaine in a manner that reduces cocaine seeking but not food seeking.
🧪💊🧠🐀 #neuroskyence
www.nature.com/articles/d41...
These ion channels have been used to engineer neural circuits in rats to respond to cocaine in a manner that reduces cocaine seeking but not food seeking.
🧪💊🧠🐀 #neuroskyence
www.nature.com/articles/d41...
Cocaine-activated ion channels engineered to break the loop of addiction in rats
Engineered ion channels reverse the effects of cocaine on activity in the brain’s lateral habenula to suppress drug seeking in rats.
www.nature.com
September 9, 2025 at 6:19 AM
Cocaine-activated ion channels engineered to break the loop of addiction in rats.
These ion channels have been used to engineer neural circuits in rats to respond to cocaine in a manner that reduces cocaine seeking but not food seeking.
🧪💊🧠🐀 #neuroskyence
www.nature.com/articles/d41...
These ion channels have been used to engineer neural circuits in rats to respond to cocaine in a manner that reduces cocaine seeking but not food seeking.
🧪💊🧠🐀 #neuroskyence
www.nature.com/articles/d41...
Reposted
The International Brain Laboratory presents in Nature a brain-wide electrophysiological map that represents a resource for understanding how computations distributed across and within brain areas drive behaviour. go.nature.com/4nnnmhg 🧪 🧠📈
September 9, 2025 at 4:19 PM
The International Brain Laboratory presents in Nature a brain-wide electrophysiological map that represents a resource for understanding how computations distributed across and within brain areas drive behaviour. go.nature.com/4nnnmhg 🧪 🧠📈
Reposted
𝗪𝗵𝗲𝗿𝗲 𝗱𝗼 𝗿𝗲𝘄𝗮𝗿𝗱𝘀 (𝘃𝗮𝗹𝘂𝗲) 𝗰𝗼𝗺𝗲 𝗳𝗿𝗼𝗺?
Implications for reinforcement learning.
Very interesting paper.
doi.org/10.1016/j.ti...
#neuroskyence
Implications for reinforcement learning.
Very interesting paper.
doi.org/10.1016/j.ti...
#neuroskyence
September 3, 2025 at 4:27 PM
𝗪𝗵𝗲𝗿𝗲 𝗱𝗼 𝗿𝗲𝘄𝗮𝗿𝗱𝘀 (𝘃𝗮𝗹𝘂𝗲) 𝗰𝗼𝗺𝗲 𝗳𝗿𝗼𝗺?
Implications for reinforcement learning.
Very interesting paper.
doi.org/10.1016/j.ti...
#neuroskyence
Implications for reinforcement learning.
Very interesting paper.
doi.org/10.1016/j.ti...
#neuroskyence
Reposted
5-HT-mediated depolarization of OFC PV neurons occurs via activation of 2A, not 2C, receptors. And 2A antagonism works similarly in males and females www.nature.com/articles/s41...
Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity - Scientific Reports
Scientific Reports - Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity
www.nature.com
July 21, 2025 at 2:28 PM
5-HT-mediated depolarization of OFC PV neurons occurs via activation of 2A, not 2C, receptors. And 2A antagonism works similarly in males and females www.nature.com/articles/s41...
Reposted
New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!
Sex‐Specific Adaptations to VTA Circuits Following Subchronic Stress
Subchronic variable stress, a paradigm shown to have divergent behavioral effects in males and females, induces shared and distinct physiological adaptations in the VTA. While both males and females ...
onlinelibrary.wiley.com
June 12, 2025 at 3:34 PM
New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!
Reposted
Reposted
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations - Nature Communications
Functional roles of natural acetylcholine (ACh) dynamics are not fully understood. This study reveals dynamic changes in ACh release across the mouse striatum during learning and extinction, identifyi...
www.nature.com
June 4, 2025 at 6:25 PM
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...
Local inhibitory circuits mediate cortical reactivations and memory consolidation
Reducing inhibitory activity after training prevents cortical reactivations and memory consolidation.
www.science.org
June 2, 2025 at 3:54 PM
New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...
Reposted
🧠 🍄 ⚡️🐭
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
May 26, 2025 at 1:36 PM
🧠 🍄 ⚡️🐭
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
Now published in @natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
Reposted
Our latest work extends ketamine’s antidepressant action and highlights the importance of a specific form of synaptic plasticity in the effects
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
May 9, 2025 at 3:23 PM
Our latest work extends ketamine’s antidepressant action and highlights the importance of a specific form of synaptic plasticity in the effects
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. www.biorxiv.org/content/10.1...
Brainstem sensing of multiple body signals during food consumption
Studies of body-to-brain communication often examine one stimulus or organ at a time, yet the brain must integrate many body signals during behavior. For example, food consumption generates diverse or...
www.biorxiv.org
April 29, 2025 at 7:48 PM
I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. www.biorxiv.org/content/10.1...
Reposted
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...
www.science.org
April 17, 2025 at 11:46 PM
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Reposted
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
buff.ly/ypISrtx
April 19, 2025 at 3:21 AM
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
buff.ly/ypISrtx
Reposted
Thrilled to share our lab's first preprint on the neural mechanisms underlying helping behavior in mice! 🧠🐭 We show that dorsal hippocampal networks play a key role in rescuing a distressed peer: www.biorxiv.org/content/10.1...
www.biorxiv.org
April 19, 2025 at 4:06 PM
Thrilled to share our lab's first preprint on the neural mechanisms underlying helping behavior in mice! 🧠🐭 We show that dorsal hippocampal networks play a key role in rescuing a distressed peer: www.biorxiv.org/content/10.1...
Reposted
This review has turned into my go-to paper for rodent PFC circuit. Useful in the lab and for teaching. Thanks @panastasiades.bsky.social and @carterlab.bsky.social for writing this. www.cell.com/trends/neuro...
Circuit organization of the rodent medial prefrontal cortex
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted
in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous
variety of projection neurons a...
www.cell.com
February 18, 2025 at 9:21 AM
This review has turned into my go-to paper for rodent PFC circuit. Useful in the lab and for teaching. Thanks @panastasiades.bsky.social and @carterlab.bsky.social for writing this. www.cell.com/trends/neuro...
Reposted
✨ Announcing a new glutamate indicator - iGluSnFR4! ✨
Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.
More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...
🧠📈
Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.
More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...
🧠📈
March 25, 2025 at 10:24 PM
✨ Announcing a new glutamate indicator - iGluSnFR4! ✨
Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.
More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...
🧠📈
Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.
More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...
🧠📈
Reposted
Proud to have contributed to @jiaxuanqi.bsky.social's masterpiece out @nature.com! She shows that dopamine transients track the learned quality of song during juvenile learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism! (1/x)
Dual neuromodulatory dynamics underlie birdsong learning - Nature
Dopamine release in the basal ganglia of the zebra finch is driven by neurons associated with reinforcement learning and by cholinergic signalling, and tracks performance quality during long-term lear...
www.nature.com
March 12, 2025 at 4:54 PM
Proud to have contributed to @jiaxuanqi.bsky.social's masterpiece out @nature.com! She shows that dopamine transients track the learned quality of song during juvenile learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism! (1/x)
Reposted
🧠🍽️ Satiety neurons that make you crave sugar? 🍬 New research shows that POMC neurons, typically linked to appetite suppression, release opioids in the thalamus, flipping the switch to increase sugar intake.
#neuroskyence 🧪 #appetite
#neuroskyence 🧪 #appetite
Thalamic opioids from POMC satiety neurons switch on sugar appetite
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...
www.science.org
February 16, 2025 at 7:20 AM
🧠🍽️ Satiety neurons that make you crave sugar? 🍬 New research shows that POMC neurons, typically linked to appetite suppression, release opioids in the thalamus, flipping the switch to increase sugar intake.
#neuroskyence 🧪 #appetite
#neuroskyence 🧪 #appetite
Reposted
Overwriting an instinct: Visual cortex instructs learning to suppress fear responses | Science www.science.org/doi/10.1126/...
#neuroskyence
#neuroskyence
Overwriting an instinct: Visual cortex instructs learning to suppress fear responses
Fast instinctive responses to environmental stimuli can be crucial for survival but are not always optimal. Animals can adapt their behavior and suppress instinctive reactions, but the neural pathways...
www.science.org
February 11, 2025 at 12:08 PM
Overwriting an instinct: Visual cortex instructs learning to suppress fear responses | Science www.science.org/doi/10.1126/...
#neuroskyence
#neuroskyence
Reposted
An #astrocytic ensemble that emerges in the nucleus accumbens upon activity during cue-motivated behaviors and is essential for modulating cue-reward associations 🧪🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior - Nature Neuroscience
Using the AstroLight system, the authors reveal that astrocytic ensembles in the nucleus accumbens regulate cue-motivated reward behavior, demonstrating that selective manipulation of tagged astrocyte...
www.nature.com
February 3, 2025 at 4:26 PM
An #astrocytic ensemble that emerges in the nucleus accumbens upon activity during cue-motivated behaviors and is essential for modulating cue-reward associations 🧪🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control
The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.
www.thetransmitter.org
January 24, 2025 at 3:04 PM
The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
Reposted
Womp-womp:😂😂😂
Sexually dimorphic dopaminergic circuits determine sex preference
www.science.org/doi/10.1126/...
#Neuroscience #Sex
Sexually dimorphic dopaminergic circuits determine sex preference
www.science.org/doi/10.1126/...
#Neuroscience #Sex
Sexually dimorphic dopaminergic circuits determine sex preference
Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...
www.science.org
January 14, 2025 at 4:25 PM
Womp-womp:😂😂😂
Sexually dimorphic dopaminergic circuits determine sex preference
www.science.org/doi/10.1126/...
#Neuroscience #Sex
Sexually dimorphic dopaminergic circuits determine sex preference
www.science.org/doi/10.1126/...
#Neuroscience #Sex
Reposted
As I board my flight home for the holidays, I wanted to share that a review I wrote with @talialerner.bsky.social just came out! It’s titled “How dopamine enables learning from aversion.” Super grateful for the opportunity - hope you can check it out! 😊😊🎄🎄
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
How dopamine enables learning from aversion
Dopamine is heavily studied for its role in reward learning, but it is becoming increasingly appreciated that dopamine can also enable learning from a…
www.sciencedirect.com
December 22, 2024 at 6:59 PM
As I board my flight home for the holidays, I wanted to share that a review I wrote with @talialerner.bsky.social just came out! It’s titled “How dopamine enables learning from aversion.” Super grateful for the opportunity - hope you can check it out! 😊😊🎄🎄
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...