Raj Rajnarayanan
@rajlabn.bsky.social
@Rajlabn in Twitter | My posts are my own
Canada could face ‘worst kind’ of flu season as experts warn evolving strain may be mismatch for vaccine
H/T @laurenpelley.bsky.social
www.cbc.ca/news/health/...
H/T @laurenpelley.bsky.social
www.cbc.ca/news/health/...
Canada could face ‘worst kind’ of flu season as experts warn evolving strain may be mismatch for vaccine | CBC News
With flu cases now rising in Canada, medical experts are bracing for a difficult influenza season linked to the global spread of an evolving H3N2 strain that could be a mismatch for this year’s vaccin...
www.cbc.ca
November 12, 2025 at 11:22 PM
Canada could face ‘worst kind’ of flu season as experts warn evolving strain may be mismatch for vaccine
H/T @laurenpelley.bsky.social
www.cbc.ca/news/health/...
H/T @laurenpelley.bsky.social
www.cbc.ca/news/health/...
Note: My initial dashboard missed a few sequences with missing nucleotides. Thanks to @josetteschoenma.bsky.social and @siamosolocani.bsky.social for nucleotide queries which pick up all BA.3.2* as of now.
November 9, 2025 at 6:43 PM
Note: My initial dashboard missed a few sequences with missing nucleotides. Thanks to @josetteschoenma.bsky.social and @siamosolocani.bsky.social for nucleotide queries which pick up all BA.3.2* as of now.
Pango issue, spotting & designation history:
github.com/cov-lineages...
github.com/cov-lineages...
November 9, 2025 at 6:42 PM
Pango issue, spotting & designation history:
github.com/cov-lineages...
github.com/cov-lineages...
Excellent thread on BA.3 from @ryanhisner.bsky.social bsky.app/profile/ryan...
Do you remember BA.3—the weakling cousin of BA.1 & BA.2 that seemed to take the worst from each & had weaker ACE2 binding than even the ancestral Wuhan Virus?
After three years, BA.3 is back.
And it is transmitting.
Who saw this coming?
1/13
After three years, BA.3 is back.
And it is transmitting.
Who saw this coming?
1/13
November 9, 2025 at 6:41 PM
Excellent thread on BA.3 from @ryanhisner.bsky.social bsky.app/profile/ryan...
BA.3.2 exhibits robust antibody evasion + low ACE2-binding capability (Guo et al, 2025; thelancet.com/journals/lan...
November 9, 2025 at 6:40 PM
BA.3.2 exhibits robust antibody evasion + low ACE2-binding capability (Guo et al, 2025; thelancet.com/journals/lan...
Thanks to all the countries that are supporting #SARSCoV2 testing & rapidly submitting sequences to @GISAID
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #Canada #USA #France #Spain #Germany #Netherlands #Australia #Slovenia
3/n
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #Canada #USA #France #Spain #Germany #Netherlands #Australia #Slovenia
3/n
November 5, 2025 at 4:08 AM
Thanks to all the countries that are supporting #SARSCoV2 testing & rapidly submitting sequences to @GISAID
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #Canada #USA #France #Spain #Germany #Netherlands #Australia #Slovenia
3/n
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #Canada #USA #France #Spain #Germany #Netherlands #Australia #Slovenia
3/n
This analysis includes #SARSCoV2 sequences submitted to
@GISAID with sample collection dates on or after 10/04/2025 (3,862 sequences)
Note: 171,095 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
@GISAID with sample collection dates on or after 10/04/2025 (3,862 sequences)
Note: 171,095 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
November 5, 2025 at 4:07 AM
This analysis includes #SARSCoV2 sequences submitted to
@GISAID with sample collection dates on or after 10/04/2025 (3,862 sequences)
Note: 171,095 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
@GISAID with sample collection dates on or after 10/04/2025 (3,862 sequences)
Note: 171,095 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
Thanks to all the countries that are supporting #SARSCoV2 testing & rapidly submitting sequences to @GISAID
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #USA #France #Canada #Spain #Netherlands #Australia #Germany #Italy
3/n
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #USA #France #Canada #Spain #Netherlands #Australia #Germany #Italy
3/n
October 27, 2025 at 5:27 AM
Thanks to all the countries that are supporting #SARSCoV2 testing & rapidly submitting sequences to @GISAID
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #USA #France #Canada #Spain #Netherlands #Australia #Germany #Italy
3/n
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #UnitedKingdom #USA #France #Canada #Spain #Netherlands #Australia #Germany #Italy
3/n
This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 09/25/2025 (4,684 sequences)
Note: 164,341 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
Note: 164,341 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
October 27, 2025 at 5:26 AM
This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 09/25/2025 (4,684 sequences)
Note: 164,341 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
Note: 164,341 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
These are sequences with sample collection dates in the last 30 days - I can check if this is missing some seqs
October 17, 2025 at 4:01 PM
These are sequences with sample collection dates in the last 30 days - I can check if this is missing some seqs
October 17, 2025 at 5:11 AM
Thanks to all the countries that are supporting #SARSCoV2 testing & rapidly submitting sequences to @GISAID
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #Canada #USA #UnitedKingdom #Spain #France #Australia #Netherlands #Italy #Germany
3/n
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #Canada #USA #UnitedKingdom #Spain #France #Australia #Netherlands #Italy #Germany
3/n
October 17, 2025 at 5:11 AM
Thanks to all the countries that are supporting #SARSCoV2 testing & rapidly submitting sequences to @GISAID
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #Canada #USA #UnitedKingdom #Spain #France #Australia #Netherlands #Italy #Germany
3/n
Top submitters (> 100 Seqs w/ collection dates in the last 30 days): #Canada #USA #UnitedKingdom #Spain #France #Australia #Netherlands #Italy #Germany
3/n
This analysis includes #SARSCoV2 sequences submitted to
@GISAID with sample collection dates on or after 09/16/2025 (5,714 sequences)
Note: 157,144 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
@GISAID with sample collection dates on or after 09/16/2025 (5,714 sequences)
Note: 157,144 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
October 17, 2025 at 5:10 AM
This analysis includes #SARSCoV2 sequences submitted to
@GISAID with sample collection dates on or after 09/16/2025 (5,714 sequences)
Note: 157,144 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
@GISAID with sample collection dates on or after 09/16/2025 (5,714 sequences)
Note: 157,144 SARSCoV2 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/29/2025 (4,212 sequences)
Note: 146,261 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
Note: 146,261 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
October 6, 2025 at 6:30 AM
This analysis includes #SARSCoV2 sequences submitted to @GISAID with sample collection dates on or after 08/29/2025 (4,212 sequences)
Note: 146,261 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
Note: 146,261 seqs w/ collection dates on or after 01/01/2025 are available in GISAID/NCBI
2/n
XFG* mutations under watch
Spike K529T is worth watching (its one of the signature mutations of XFG.14 lineage)
Spike K529T is worth watching (its one of the signature mutations of XFG.14 lineage)
September 15, 2025 at 4:11 AM
XFG* mutations under watch
Spike K529T is worth watching (its one of the signature mutations of XFG.14 lineage)
Spike K529T is worth watching (its one of the signature mutations of XFG.14 lineage)
Status of #COVID19 in #California
XFG.3, XFG, XFG.2 and PQ.2 are the top circulating #SARSCoV2 lineages in CA |[🚨Low sequence count]
#COVID19 hospitalizations -low | #WasteWater #SARSCoV2 - Very High | @capublichealth.bsky.social
XFG.3, XFG, XFG.2 and PQ.2 are the top circulating #SARSCoV2 lineages in CA |[🚨Low sequence count]
#COVID19 hospitalizations -low | #WasteWater #SARSCoV2 - Very High | @capublichealth.bsky.social
September 15, 2025 at 4:10 AM
Status of #COVID19 in #California
XFG.3, XFG, XFG.2 and PQ.2 are the top circulating #SARSCoV2 lineages in CA |[🚨Low sequence count]
#COVID19 hospitalizations -low | #WasteWater #SARSCoV2 - Very High | @capublichealth.bsky.social
XFG.3, XFG, XFG.2 and PQ.2 are the top circulating #SARSCoV2 lineages in CA |[🚨Low sequence count]
#COVID19 hospitalizations -low | #WasteWater #SARSCoV2 - Very High | @capublichealth.bsky.social