QSPainRelief EU Project
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qspainrelief.bsky.social
QSPainRelief EU Project
@qspainrelief.bsky.social
QSPainRelief is an EU-funded research project for #ChronicPain patients. We use a translational quantitative systems #pharmacology (#QSP) approach and computer models to identify the best combinatorial #PainRelief treatments.

🌐 https://qspainrelief.eu
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20% live with #ChronicPain - many without effective treatment

The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies

🎥 Intro video: youtu.be/0VWoc2fqks8
🔗 Database: qspainrelief.lacdr.leidenuniv.nl

#PainRelief #PersonalisedMedicine
Introduction to the QSPainRelief Database (by Daan van Valkengoed, Leiden University, NL)
YouTube video by concentris research management
youtu.be
✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability

🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado

#Neuroscience #Analgesics
October 3, 2025 at 6:59 PM
🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment.

✅ Less pain
😵‍💫 Fewer side effects
☺️ Better QoL

✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
October 3, 2025 at 6:02 PM
🔬 Wanna know the P-values for #agonist-dependent #GPCR activation?

👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:

📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.

🔗 www.nature.com/articles/s41...
October 3, 2025 at 4:07 PM
🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about

👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE

🔗 doi.org/10.1016/j.dr...

#allostery #pharmacology #DrugDesign #GPCRs
October 3, 2025 at 1:22 PM
🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊

🔗 doi.org/10.1016/j.bc...

#Pharmacology #GPCRs
October 3, 2025 at 12:29 PM
🔦 Spotlight on link.springer.com/article/10.1...

🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs

✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential

#TranslationalPharmacology #DrugDevelopment
October 3, 2025 at 12:13 PM
🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.

💡This might also explain some inter-individual differences!

🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
October 3, 2025 at 11:08 AM
Reposted by QSPainRelief EU Project
We have exceptional treatments for RMDs but that doesn't always mean the chronic pain is treated. We need to be open to pain specialists. Patients need to keep advocating for themselves when still in pain despite their RMD appearing under control. Nadia Malliou at #eular2025 @eular.org
June 14, 2025 at 7:15 AM
🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.

Potential impact:

👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability

🔗 www.page-meeting.org/default.asp?...

#ChronicPain #Pain
October 3, 2025 at 10:21 AM
📖 Just published 💊

👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏

🔗 www.sciencedirect.com/science/arti...

#Pharmacology #ComputationalBiology
October 3, 2025 at 9:47 AM
🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions.

🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
October 3, 2025 at 9:35 AM
🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear.

👉 Social support is crucial, but HOW matters

🔗 doi.org/10.1371/jour...

#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social
October 3, 2025 at 7:48 AM
🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds).
link.springer.com/article/10.1...

👉Best algorithm: Random Forest

💡Great for #CNS drug discovery!

#BBB #PBPK #ML
October 1, 2025 at 12:20 PM
💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure?

🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.

#BBB #DrugInteractions #morphine #modelling #brain

🔗 link.springer.com/article/10.1...
September 30, 2025 at 5:26 PM
Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025)

👉 onlinelibrary.wiley.com/doi/10.1002/...

⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later.

#PainPrediction
September 29, 2025 at 10:12 AM
🧠 Central sensitisation drives #ChronicPain.

This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation.

👉 Explore the mechanisms behind persistent pain!

🔗 dial.uclouvain.be/pr/boreal/ob...
September 26, 2025 at 9:50 AM
🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭

#EndogenousOpioids matter, folks!
#BindingKinetics #MOR

www.sciencedirect.com/science/arti...
September 25, 2025 at 11:24 AM
💡What happens when you combine 2 analgesics?

🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses.

pubs.acs.org/doi/10.1021/...
September 24, 2025 at 12:37 PM
20% live with #ChronicPain - many without effective treatment

The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies

🎥 Intro video: youtu.be/0VWoc2fqks8
🔗 Database: qspainrelief.lacdr.leidenuniv.nl

#PainRelief #PersonalisedMedicine
Introduction to the QSPainRelief Database (by Daan van Valkengoed, Leiden University, NL)
YouTube video by concentris research management
youtu.be
September 20, 2025 at 4:28 PM
🎓 Dive into the complexity of #OpioidReceptors with Prof. Andrea Bedini (from @unibo.it) in his insightful Masterclass.

👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics!

▶️ youtu.be/dcGBm03nvhI

#GPCR #ChronicPain #Pharmacology

@iasp.bsky.social
@efic.bsky.social
QSPainRelief Masterclass - Opioid Receptors & Quantitative Systems Pharmacology (Andrea Bedini)
YouTube video by concentris research management
youtu.be
July 30, 2025 at 4:54 PM
Wrapping things up for our final deliverables in fresh #SpringTime spirit: Our Steering Committee assembles for the last time as we shift into top-gear productivity 🚀until the end of June! 😎

#ChronicPain #PersonalisedMedicine
#DrugCombinations #PainRelief
@horizoneu.bsky.social
@efic.bsky.social
May 26, 2025 at 1:55 PM
🥳 Congrats, Solenn Gousset, from André Mouraux's group at Université catholique de Louvain for defending your PhD thesis "Novel approaches to investigate #CentralSensitization: From #experimental models to #clinical perspectives" on 25 March - what an accomplishment! 👏

#PainResearch #Neuroscience
April 4, 2025 at 11:42 AM
🌟 Highlights ✨of the 6th #QSPainRelief General Assembly (GA) in Bologna from 9-11 Dec 2024. We still have much work ahead in 2025 but gained lots of energy & momentum during our final in-person GA! 💪
#PainRelief #ChronicPain #SystemsPharmacology #neuroscience #PersonalisedMedicine @efic.bsky.social
January 21, 2025 at 5:49 PM
☺️ Welcome! 😊
You can now also follow us here on Bluesky.
Spearheaded by ULEI (@unileiden.bsky.social), 10 partners joined forces for the QSPainRelief project in January 2020 to develop personalised #QSP (Quantitative Systems Pharmacology) based combinatorial treatments for #ChronicPain patients.
January 16, 2025 at 6:12 PM