🌐 https://qspainrelief.eu
The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies
🎥 Intro video: youtu.be/0VWoc2fqks8
🔗 Database: qspainrelief.lacdr.leidenuniv.nl
#PainRelief #PersonalisedMedicine
🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado
#Neuroscience #Analgesics
🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado
#Neuroscience #Analgesics
✅ Less pain
😵💫 Fewer side effects
☺️ Better QoL
✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
✅ Less pain
😵💫 Fewer side effects
☺️ Better QoL
✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:
📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.
🔗 www.nature.com/articles/s41...
👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:
📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.
🔗 www.nature.com/articles/s41...
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
🔗 doi.org/10.1016/j.bc...
#Pharmacology #GPCRs
🔗 doi.org/10.1016/j.bc...
#Pharmacology #GPCRs
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
Potential impact:
👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability
🔗 www.page-meeting.org/default.asp?...
#ChronicPain #Pain
Potential impact:
👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability
🔗 www.page-meeting.org/default.asp?...
#ChronicPain #Pain
👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏
🔗 www.sciencedirect.com/science/arti...
#Pharmacology #ComputationalBiology
👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏
🔗 www.sciencedirect.com/science/arti...
#Pharmacology #ComputationalBiology
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
👉 Social support is crucial, but HOW matters
🔗 doi.org/10.1371/jour...
#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social
👉 Social support is crucial, but HOW matters
🔗 doi.org/10.1371/jour...
#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
👉 onlinelibrary.wiley.com/doi/10.1002/...
⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later.
#PainPrediction
👉 onlinelibrary.wiley.com/doi/10.1002/...
⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later.
#PainPrediction
This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation.
👉 Explore the mechanisms behind persistent pain!
🔗 dial.uclouvain.be/pr/boreal/ob...
This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation.
👉 Explore the mechanisms behind persistent pain!
🔗 dial.uclouvain.be/pr/boreal/ob...
#EndogenousOpioids matter, folks!
#BindingKinetics #MOR
www.sciencedirect.com/science/arti...
#EndogenousOpioids matter, folks!
#BindingKinetics #MOR
www.sciencedirect.com/science/arti...
🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses.
pubs.acs.org/doi/10.1021/...
🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses.
pubs.acs.org/doi/10.1021/...
The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies
🎥 Intro video: youtu.be/0VWoc2fqks8
🔗 Database: qspainrelief.lacdr.leidenuniv.nl
#PainRelief #PersonalisedMedicine
The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies
🎥 Intro video: youtu.be/0VWoc2fqks8
🔗 Database: qspainrelief.lacdr.leidenuniv.nl
#PainRelief #PersonalisedMedicine
👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics!
▶️ youtu.be/dcGBm03nvhI
#GPCR #ChronicPain #Pharmacology
@iasp.bsky.social
@efic.bsky.social
👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics!
▶️ youtu.be/dcGBm03nvhI
#GPCR #ChronicPain #Pharmacology
@iasp.bsky.social
@efic.bsky.social
#ChronicPain #PersonalisedMedicine
#DrugCombinations #PainRelief
@horizoneu.bsky.social
@efic.bsky.social
#ChronicPain #PersonalisedMedicine
#DrugCombinations #PainRelief
@horizoneu.bsky.social
@efic.bsky.social
#PainResearch #Neuroscience
#PainResearch #Neuroscience
#PainRelief #ChronicPain #SystemsPharmacology #neuroscience #PersonalisedMedicine @efic.bsky.social
#PainRelief #ChronicPain #SystemsPharmacology #neuroscience #PersonalisedMedicine @efic.bsky.social
You can now also follow us here on Bluesky.
Spearheaded by ULEI (@unileiden.bsky.social), 10 partners joined forces for the QSPainRelief project in January 2020 to develop personalised #QSP (Quantitative Systems Pharmacology) based combinatorial treatments for #ChronicPain patients.
You can now also follow us here on Bluesky.
Spearheaded by ULEI (@unileiden.bsky.social), 10 partners joined forces for the QSPainRelief project in January 2020 to develop personalised #QSP (Quantitative Systems Pharmacology) based combinatorial treatments for #ChronicPain patients.