Princess Margaret Cancer Centre
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pmresearch-uhn.bsky.social
Princess Margaret Cancer Centre
@pmresearch-uhn.bsky.social
The Princess Margaret Cancer Centre is Canada’s largest integrated cancer research, teaching, and treatment centre, one of the top cancer research centres in the world and is one of the University Health Network’s six research institutes.
Pinned
“I’m very excited by this new frontier where imaging can play a key role in improving our understanding of tumour biology. This type of work has never been done before,” said Dr. DaCosta on visualizing the interaction between leukemia cells and immune cells.
www.uhnresearch.ca/n...
Congratulations to our Senior Scientist Dr. Steven Chan, whose publication “Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs” in Nature has received Paper of the Year Award from Canadian Hematology Society.
canadianhematologysociety.org/awards/canad...
@uhnresearch.ca @uhn.ca
Diabetes drug for preventing blood cancer?

Our study in @nature.com shows potentials to repurpose metformin to reduce risks of blood cancers & inflammatory illnesses in clonal hematopoiesis patients with DNMT3A(R882) mutations.

doi.org/10.1038/s415...

@uhnresearch.bsky.social
November 24, 2025 at 2:59 PM
New strategy involving immunotherapy improved progression-free survival for patients with biliary tract cancers derived from inflamed and scarred bile ducts.
Led by Dr. Robert Grant's team at @uhn.ca @uhnresearch.ca @oicr.on.ca & @mdanderson.bsky.social.
@theaacr.bsky.social
doi.org/10.1158/1078...
Clinicogenomic Characterization of Primary Sclerosing Cholangitis-Associated Biliary Tract Cancers
Abstract. Purpose: Biliary tract cancer (BTC) is the leading cause of death in patients with primary sclerosing cholangitis (PSC). PSC-related BTC is poorly understood, and the risks and benefits of c...
doi.org
November 20, 2025 at 3:05 PM
CRISPR genome editing has transformed medicine. Now, AI is taking it further. This review by Dr. Bowen Li at @uhn.ca’s @pmresearch-uhn.bsky.social explores how machine learning is shaping the next era of precision therapeutics.
www.nature.com/articles/s41...
@uhnresearch.ca
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies - Nature Reviews Genetics
CRISPR-based genome editing has revolutionized biotechnology, enabling precise DNA modifications for research and therapy. The authors review how artificial intelligence, including deep learning, is a...
www.nature.com
November 18, 2025 at 3:26 PM
From leading photodynamic therapy to innovating fluorescence-guided surgery, our Senior Scientist Dr. Brian Wilson @uhn.ca @uhnresearch.ca and his visionary work has shaped the global landscape of biophotonics.

Read more in @spie.org's special issue: doi.org/10.1117/1.JB...
November 14, 2025 at 4:49 PM
Reposted by Princess Margaret Cancer Centre
Advancing research with and for communities.

Equity should be built into every stage of care. @uhn.ca researchers are ‘Transforming the Landscape’ by reducing barriers and addressing cultural safety.

➡️ Learn more: www.uhnresearch.ca/Research-Rep...

#RR25 #DiscoveryToImpact
November 14, 2025 at 4:23 PM
New research shows that a common mutation in blood stem cells (TET2) may boost the effectiveness of immunotherapy, enhancing response to immune checkpoint inhibitors, led by Drs. Robert Vanner and John Dick at @uhn.ca @uhnresearch.ca @pmresearch-uhn.bsky.social.

aacrjournals.org/cancerres/ar...
November 12, 2025 at 2:51 PM
New study shows oral combo of enasidenib + venetoclax helps 62% of patients with IDH2 mutated, relapsed or refractory #AML achieve remission. Safe, effective, and outpatient-friendly. Led by our Drs. Steven Chan & Guillaume Richard-Carpentier.
@thelancethaem.bsky.social:
doi.org/10.1016/S235...
November 11, 2025 at 3:30 PM
Reposted by Princess Margaret Cancer Centre
#NETCancerDay

Neuroendocrine tumours (NETs) are rapidly rising, but most Canadians with NETs aren’t accurately diagnosed or are diagnosed too late. With TFRI support, Drs. Hon Leong and Benjamin Lok are uniting experts nationwide to transform NETs care.

Learn more: www.tfri.ca/our-research...
November 10, 2025 at 10:36 PM
Explore @uhnresearch.ca’s new Research Report: Driving Discovery, Delivering Impact.

See how purpose-driven research is turning bold ideas into real-world impact, including cancer research at Princess Margaret.

www.uhnresearch.ca/Research-Rep...
#RR25 #DiscoveryToImpact
Driving Discovery. Delivering Impact.🎯

A story of science that’s bold, transformative, and collaborative.

This #WorldScienceDay, explore our annual research report and discover how @uhn.ca is building #AHealthierWorld.

➡️: www.uhnresearch.ca/Research-Rep...

#RR25 #DiscoveryToImpact
November 10, 2025 at 4:14 PM
Reposted by Princess Margaret Cancer Centre
Something big is coming...

Stay tuned as we prepare to launch our annual research report—showcasing how discovery drives impact at @uhn.ca.

#RR25 #DiscoveryToImpact
November 7, 2025 at 7:00 PM
Reposted by Princess Margaret Cancer Centre
As the 1st Canadian hospital to join a cross-border genomics network to sequence 1.6M patient exomes, @pmresearch-uhn.bsky.social will uncover genetic risks for cancer & high cholesterol. A powerful example of research in action with potential to save lives: www.theglobeandmail.com/canada/artic...
Cancer patients to be offered genomic testing as part of a joint study with U.S. hospitals
Screening in partnership with Helix, Inc. could offer Princess Margaret Cancer Centre patients insights into hereditary health risks
www.theglobeandmail.com
November 6, 2025 at 6:33 PM
Reposted by Princess Margaret Cancer Centre
Princess Margaret, Canada's largest cancer centre, to enroll 100,000 cancer patients genomic testing trial to see if major hereditary health risks lurk in their DNA, by @kellygrant1.bsky.social www.theglobeandmail.com/canada/artic... via @theglobeandmail.com @pmresearch-uhn.bsky.social #genomics
Cancer patients to be offered genomic testing as part of a joint study with U.S. hospitals
Screening in partnership with Helix, Inc. could offer Princess Margaret Cancer Centre patients insights into hereditary health risks
www.theglobeandmail.com
November 6, 2025 at 2:20 PM
Reposted by Princess Margaret Cancer Centre
First trip to Weatern Canada for ECR workshop and #CCRC2025 in #Calgary. Terrific time making new connections in #cancerresearch and reconnecting with colleagues @pmresearch-uhn.bsky.social @sickkidsto.bsky.social.
November 4, 2025 at 11:19 PM
Congratulations to our Senior Scientist Dr. Rama Khokha on receiving the renewal of Canada Research Chair funding!
Five @uhn.ca researchers received Canada Research Chair funding to advance research on #osteoarthritis, #tumour microenvironments, #BrainHealth, #CardiovascularDisease in cancer patients, and the development of collaborative #robots! 🍁👏

🔗: www.uhnresearch.ca/news/recogni...
November 4, 2025 at 5:26 PM
Reposted by Princess Margaret Cancer Centre
We are proud to recognize John E. Dick of @pmresearch-uhn.bsky.social as a #CitationLaureate 2025 in Physiology or Medicine. Congratulations and thank you for the hospitality @pmresearch-uhn.bsky.social!

#CitationLaureates #Clarivate #ResearchImpact
November 4, 2025 at 1:25 PM
The Lancet Oncology Commission—co-led by our Dr. Gary Rodin @uhn.ca—calls for urgent action to address the human crisis in cancer care. Survival is improving, but psychological, social and cultural support must be core to care.

www.sciencedirect.com/science/arti...
@uhnresearch.ca @thelancet.com
November 3, 2025 at 6:59 PM
🏆 We were honoured to welcome guests from @clarivateag.bsky.social to @uhn.ca's Princess Margaret Cancer Centre for a special award ceremony recognizing Dr. John Dick as a 2025 Clarivate Citation Laureate for his pioneering work in #leukemia stem cell research.
www.uhnresearch.ca/news/uhn-sci...
October 31, 2025 at 3:32 PM
A new tumour-customizable nanomedicine system showed efficient mRNA delivery to cancer cells in melanoma and triple-negative breast cancer preclinical models while minimizing harmful effects in healthy tissues.
Developed by Dr. Bowen Li @uhn.ca UofTPharmacy: www.pharmacy.utoronto.ca/news-announc...
New nanomedicine platform “TITUR” shows promise for advancing personalized mRNA cancer therapeutics
Researchers share new study presenting a tumour-customizable mRNA nanomedicine platform that demonstrates efficient mRNA delivery to cancer cells.
www.pharmacy.utoronto.ca
October 29, 2025 at 3:42 PM
Reposted by Princess Margaret Cancer Centre
October 28, 2025 at 12:14 PM
A team led by Dr. Benjamin Lok has found a new target to enhance radiation therapy in small cell lung cancer. By removing the function of gene HDAC3, cancer cells became more sensitive to radiation and tumour growth was inhibited:
aacrjournals.org/mct/article/...;
www.uhnresearch.ca/news/increas...
October 22, 2025 at 2:17 PM
A new generation of Porphysomes showed an 11-fold increase in cancer cell uptake and longer-lasting immunity against tumour recurrence in preclinical phototherapy studies, led by Drs. Gang Zheng and Juan Chen's team at UHN's Princess Margaret Cancer Centre.

pubs.acs.org/doi/10.1021/...
A Membrane Fluidization Strategy Significantly Boosts Photodynamic Therapy and Antitumor Immunity of Porphyrin-Lipid Nanoparticles
Porphysomes (PS) are self-assembled porphyrin–lipid nanoparticles with intrinsic multifunctionality for cancer theranostics. We recently discovered that incorporating EDTA-conjugated lipids (EDTA-lipi...
pubs.acs.org
October 21, 2025 at 6:42 PM
Congratulations to our Medical Oncologist Dr. Robert Vanner, whose team was awarded $1 million through 2025 Translational Research Grant in Brain Cancer to advance glioblastoma research, jointly funded by @braincanada.bsky.social and the Cancer Research Society 🎉

braincanada.ca/announcement...
Advancing Brain Cancer Research
Brain Canada and CRS fund two teams under the 2025 Translational Research Grants to advance brain cancer research
braincanada.ca
October 20, 2025 at 3:43 PM
Congratulations to our Dr. David Kirsch on being elected to the National Academy of Medicine for advancing sarcoma care!

nam.edu/news-and-ins...

uhnresearch.ca/news/top-hon...

@uhn.ca @uhnresearch.ca @nam.edu
October 20, 2025 at 2:33 PM
How do we SEE what’s happening in a tumour? 👀

Meet Dr. Ralph DaCosta, an optical physicist turned cancer researcher @uhn.ca's Princess Margaret Cancer Centre. His team turns the hidden world of tumour microenvironment into a colourful map to guide treatment.

www.youtube.com/embe...
October 3, 2025 at 12:30 PM
A pivotal moment in global cancer research collaboration 🔬

We recently hosted the inaugural C8 Symposium, uniting top scientists from 8 global institutes to tackle cancer’s toughest challenges through collaboration & innovation.

www.uhnresearch.ca/news/uniting...
@uhnresearch.ca @uhn.ca
October 1, 2025 at 2:24 PM