Pablo J. Sáez
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pjsaez.bsky.social
Pablo J. Sáez
@pjsaez.bsky.social
Husband - Dad of 2 - Scientist 🇨🇱 Chilean expat.
I love to study how cells walk & talk.
PI of the @cellcommlab.bsky.social
#CellMigration #CellComm #calciumsignaling #organelles 🧪🔬
Even if "provisionally" accepted, those are the best words/news I've heard for quite a while...

Here some #blebs to "provisionally" cellebrate.
Let's see this #cell dance under the microscope.

@focalplane.bsky.social #fluorescencefriday #microscopy 🧪🔬
November 21, 2025 at 2:55 PM
I guess it never gets old...bc we love #CellMigration

ATP has many roles: energy currency, hydrotrope, and *danger signal*

Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!

www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).

Also the membrane dynamics are lovely.

It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
November 7, 2025 at 9:25 PM
Barely made ir for another #FluorescenceFriday

Ahhh the #Nucleus ... it never gets old.
This #cell has 2 bc why not !! It seems they are refusing to separate.

This 👇🏽 is an excellent chance to put your last work in the nucleus in this issue edited by @abbybuch.bsky.social @jcellsci.bsky.social
July 25, 2025 at 10:01 PM
This is why we love #cellmigration

#Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis.

I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock !

#scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬
July 8, 2025 at 10:18 AM
Do you know what happens if you squeeze a #cell?

If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)

Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬
June 28, 2025 at 12:32 PM
#FluorescenceFriday

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach *every* corner to provide energy.

All recorded under the microscope @cellcommlab.bsky.social

#scicomm #sciencesky #microscopy #organelles @focalplane.bsky.social 🧪🔬
June 20, 2025 at 7:24 PM
This is why we love #cell dynamics !

Look at this #macrophage branching exploring the surroundings videoed under the microscope

This what immune cells do in our body in search of bacteria, viruses and death cells

#microscopy #cellbio #sciencesky @focalplane.bsky.social @cellcommlab.bsky.social 🧪🔬
June 7, 2025 at 10:14 PM
An oldie (10 y!) but goodie: cellular interaction at the top! #cellcomm

Video of a T cell (orange) interacting with a target cell (blue)

From Chen et al. @ Betzig lab (@hhmijanelia.bsky.social) game changing paper !!

Full science.org/doi/10.1126/... @focalplane.bsky.social #scicomm #microscopy 🧪🔬
February 18, 2025 at 8:38 PM
#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules

#Cancer cells switch strategies during metastasis to invade other tissues

Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social
February 6, 2025 at 10:44 AM
The #nucleus contains the info of a #cell, but it does much more than that !!

Since the nucleus is *big*, acts as the main intracellular obstacle, and during #CellMigration can get 'trapped'/stuck until the cell pushes it FWD.

#scicomm @focalplane.bsky.social @cellcommlab.bsky.social
#Skyscience
February 1, 2025 at 3:45 PM
How cells decide where to go? #CellMigration

Last year we published our 1st paper @cellcommlab.bsky.social, showing how actin-based membrane oscillations define a new direction ( #cancer & non-cancer #cells )

Full www.nature.com/articles/s41...
@naturephysics.bsky.social @focalplane.bsky.social 🧪🔬
January 18, 2025 at 11:24 PM
#CellMigration meets #SciArt

Naomi Wee (naomiwee.com) did this great movie to explain how amoeboid migration works (also mesenchymal & cancer migration)

Wanna know what happens if this leukocyte chooses the wrong path? Watch this !

www.youtube.com/watch?v=mPwn... @focalplane.bsky.social #SciSky
January 13, 2025 at 9:01 AM
#CellMigration aficionados, it would be cool to have a similar video for amoeboid cell migration too, no?

Well come tomorrow and see the nice work done by Naomi Wee.

Early teaser below, you can already see membrane dynamics and the leading edge vs uropod shape

#GRCCellMigration #SciArt #GRC
January 12, 2025 at 4:34 PM
Warming up for the upcoming #GRCCellMigration

For me the best video to explain adhesion-dependent #CellMigration by Felix Donghwi Son

More in the website felixvis.artstation.com #sciart #scicomm #ScienceSky #SciSky #cytoskeleton #FocalAdhesion
January 9, 2025 at 11:53 PM