Pierre Santucci
@pierresantucci.bsky.social
PI CNRS - Aix Marseille Université 🇫🇷🇪🇺
All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊
https://pierre-santucci.owlstown.net/
All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊
https://pierre-santucci.owlstown.net/
Pinned
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
Reposted by Pierre Santucci
Editorial: Society journals matter—supporting science through renewed commitment
Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues
academic.oup.com/microlife/ad...
Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues
academic.oup.com/microlife/ad...
Editorial: Society journals matter—supporting science through renewed commitment
Paul B Rainey, Puri López-García, Zeynep Ceren Karahan, Paul Williams, Stipan Jonjić, Kenneth N Timmis; Editorial: Society journals matter—supporting scien
academic.oup.com
November 22, 2025 at 6:35 PM
Editorial: Society journals matter—supporting science through renewed commitment
Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues
academic.oup.com/microlife/ad...
Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues
academic.oup.com/microlife/ad...
Reposted by Pierre Santucci
📢 Early-Career TB Researchers: Submit short talk abstracts & scholarship apps by Nov. 24! Join us Mar 23-26, 2026 in Cape Town for cutting-edge TB & global health. 🎥Highlights: youtu.be/YcKVeGWqXSM
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Tuberculosis Meeting Promo
YouTube video by KeystoneSymposia
youtu.be
November 21, 2025 at 10:01 PM
📢 Early-Career TB Researchers: Submit short talk abstracts & scholarship apps by Nov. 24! Join us Mar 23-26, 2026 in Cape Town for cutting-edge TB & global health. 🎥Highlights: youtu.be/YcKVeGWqXSM
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Submit: keysym.us/KSTB26
@maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB
Reposted by Pierre Santucci
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Reposted by Pierre Santucci
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology
Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.
www.nature.com
November 13, 2025 at 9:44 PM
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pierre Santucci
Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/...
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
www.biorxiv.org
November 20, 2025 at 4:27 PM
Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/...
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
Reposted by Pierre Santucci
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
November 20, 2025 at 10:16 AM
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
Reposted by Pierre Santucci
Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling https://www.biorxiv.org/content/10.1101/2025.11.19.689313v1
November 20, 2025 at 8:16 AM
Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling https://www.biorxiv.org/content/10.1101/2025.11.19.689313v1
Reposted by Pierre Santucci
New graphical review out now from our Biology of B-cell Malignancies special issue
📕 Biological and technical complexities in analyzing extracellular vesicle immune interactions in B-cell malignancies
✍️ @danielbachurski.bsky.social & Michael Hallek
🔗 febs.onlinelibrary.wiley.com/doi/10.1002/...
📕 Biological and technical complexities in analyzing extracellular vesicle immune interactions in B-cell malignancies
✍️ @danielbachurski.bsky.social & Michael Hallek
🔗 febs.onlinelibrary.wiley.com/doi/10.1002/...
November 19, 2025 at 9:45 AM
New graphical review out now from our Biology of B-cell Malignancies special issue
📕 Biological and technical complexities in analyzing extracellular vesicle immune interactions in B-cell malignancies
✍️ @danielbachurski.bsky.social & Michael Hallek
🔗 febs.onlinelibrary.wiley.com/doi/10.1002/...
📕 Biological and technical complexities in analyzing extracellular vesicle immune interactions in B-cell malignancies
✍️ @danielbachurski.bsky.social & Michael Hallek
🔗 febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Pierre Santucci
👇👇Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
Tuberculosis: Understanding the Disease Across Scales | Keystone Symposia
Join us at the Keystone Symposia on Tuberculosis: Understanding the Disease Across Scales, March 2026, in Cape Town, with field leaders!
www.keystonesymposia.org
November 19, 2025 at 8:48 PM
👇👇Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
Reposted by Pierre Santucci
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
November 18, 2025 at 8:56 AM
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
Reposted by Pierre Santucci
November 14, 2025 at 3:17 AM
Reposted by Pierre Santucci
👏👏👏
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
We are thrilled to congratulate @lucianabalboa.bsky.social, co-leader of our IPBS/CNRS-CONICET lab, for receiving a special mention in the L’Oréal-UNESCO “For Women in Science” Award 2025. This honor recognizes her exceptional career & dedication to research in infectious diseases.
shorturl.at/Gfo4a
shorturl.at/Gfo4a
November 13, 2025 at 6:48 AM
👏👏👏
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
Reposted by Pierre Santucci
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
Reposted by Pierre Santucci
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 9:57 PM
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Reposted by Pierre Santucci
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
FPbase Fluorescence Spectra Viewer
An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.
www.fpbase.org
November 4, 2025 at 3:03 PM
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
Reposted by Pierre Santucci
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: [email protected]
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Reposted by Pierre Santucci
Interested in a PhD at the intersection of biophysics and microbiology?
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD....
PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...
www.findaphd.com
October 31, 2025 at 1:09 PM
Interested in a PhD at the intersection of biophysics and microbiology?
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Reposted by Pierre Santucci
🔋 Start your week with a mito Review!
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
November 3, 2025 at 9:01 AM
🔋 Start your week with a mito Review!
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
Reposted by Pierre Santucci
Want to find ways to combat TB? Check out this PhD position 👇
November 2, 2025 at 8:44 PM
Want to find ways to combat TB? Check out this PhD position 👇
Reposted by Pierre Santucci
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 30, 2025 at 3:21 AM
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by Pierre Santucci
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
October 22, 2025 at 11:10 AM
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
Reposted by Pierre Santucci
We're hiring for an Editorial Assistant!
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: [email protected]
Find the full job description here ➡️ www.febs.org/news/jobs-po...
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: [email protected]
Find the full job description here ➡️ www.febs.org/news/jobs-po...
October 21, 2025 at 12:14 PM
We're hiring for an Editorial Assistant!
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: [email protected]
Find the full job description here ➡️ www.febs.org/news/jobs-po...
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: [email protected]
Find the full job description here ➡️ www.febs.org/news/jobs-po...
Reposted by Pierre Santucci
News article in English: www.unil.ch/news/en/1760...
October 14, 2025 at 6:28 PM
News article in English: www.unil.ch/news/en/1760...
Reposted by Pierre Santucci
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
Reposted by Pierre Santucci
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
October 13, 2025 at 12:44 AM
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...