PARCC
@parcc-inserm.bsky.social
Paris Cardiovascular Research Center
Reposted by PARCC
Thank you Irene Fernandez-Ruiz for this great piece of commentary in @natrevcardiol.nature.com on the IVORY trial published in @natmed.nature.com
Main paper can be found here:
rdcu.be/eX8W3
@ziadmallat.bsky.social @18fdg.bsky.social @vpd-hlri.bsky.social @medcambridge.bsky.social
Main paper can be found here:
rdcu.be/eX8W3
@ziadmallat.bsky.social @18fdg.bsky.social @vpd-hlri.bsky.social @medcambridge.bsky.social
New online! Low-dose IL-2 therapy reduces arterial inflammation in acute coronary syndromes #CardioSky
Low-dose IL-2 therapy reduces arterial inflammation in acute coronary syndromes
Nature Reviews Cardiology, Published online: 22 January 2026; doi:10.1038/s41569-026-01256-0Treatment with low-dose IL-2 increases regulatory T cell numbers and reduces arterial inflammation in patients with an acute coronary syndrome and residual systemic inflammation compared with placebo, according to findings from the IVORY trial.
dlvr.it
January 23, 2026 at 2:12 PM
Thank you Irene Fernandez-Ruiz for this great piece of commentary in @natrevcardiol.nature.com on the IVORY trial published in @natmed.nature.com
Main paper can be found here:
rdcu.be/eX8W3
@ziadmallat.bsky.social @18fdg.bsky.social @vpd-hlri.bsky.social @medcambridge.bsky.social
Main paper can be found here:
rdcu.be/eX8W3
@ziadmallat.bsky.social @18fdg.bsky.social @vpd-hlri.bsky.social @medcambridge.bsky.social
Reposted by PARCC
"Research is messy. … Trying to protect students from that reality does them a disservice."
On #InternationalDayOfEducation, take a look back at this Working Life essay on teaching students about scientific failure. https://scim.ag/4sTaQcH
On #InternationalDayOfEducation, take a look back at this Working Life essay on teaching students about scientific failure. https://scim.ag/4sTaQcH
January 24, 2026 at 8:10 PM
"Research is messy. … Trying to protect students from that reality does them a disservice."
On #InternationalDayOfEducation, take a look back at this Working Life essay on teaching students about scientific failure. https://scim.ag/4sTaQcH
On #InternationalDayOfEducation, take a look back at this Working Life essay on teaching students about scientific failure. https://scim.ag/4sTaQcH
Dr O. Lenoir, Dr PL. Tharaux @PARCC and colleagues reveal that levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death.
Learn More: insight.jci.org/articles/vie...
Learn More: insight.jci.org/articles/vie...
JCI Insight -
Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death
insight.jci.org
January 24, 2026 at 12:33 PM
Dr O. Lenoir, Dr PL. Tharaux @PARCC and colleagues reveal that levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death.
Learn More: insight.jci.org/articles/vie...
Learn More: insight.jci.org/articles/vie...
Reposted by PARCC
"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors."
One mentor isn’t enough, wrote Erika Moore in this 2021 Working Life essay. https://scim.ag/3Zfm0e8 #NationalMentoringMonth
One mentor isn’t enough, wrote Erika Moore in this 2021 Working Life essay. https://scim.ag/3Zfm0e8 #NationalMentoringMonth
January 15, 2026 at 10:03 PM
"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors."
One mentor isn’t enough, wrote Erika Moore in this 2021 Working Life essay. https://scim.ag/3Zfm0e8 #NationalMentoringMonth
One mentor isn’t enough, wrote Erika Moore in this 2021 Working Life essay. https://scim.ag/3Zfm0e8 #NationalMentoringMonth
Reposted by PARCC
Are you a grad student struggling with a blank page? These strategies could help
go.nature.com/4jGEmhO
go.nature.com/4jGEmhO
Three tips for scientific writing: a guide for graduate students
Do you struggle with the blank page? These strategies could help.
go.nature.com
January 14, 2026 at 6:24 PM
Are you a grad student struggling with a blank page? These strategies could help
go.nature.com/4jGEmhO
go.nature.com/4jGEmhO
Reposted by PARCC
Nature research paper: Artificial intelligence tools expand scientists’ impact but contract science’s focus
go.nature.com/4pA9hNZ
go.nature.com/4pA9hNZ
Artificial intelligence tools expand scientists’ impact but contract science’s focus - Nature
Artificial intelligence boosts individual scientists’ output, citations and career progression, but collectively narrows research diversity and reduces collaboration, concentrating work in data-rich areas and potentially limiting broader scientific exploration.
go.nature.com
January 15, 2026 at 9:47 AM
Nature research paper: Artificial intelligence tools expand scientists’ impact but contract science’s focus
go.nature.com/4pA9hNZ
go.nature.com/4pA9hNZ
Dr JP Empana and colleagues @PARCC investigated the prevalence, temporal trends and associated factors of overweight and obesity among adults in the WHO African region.
Read more: gh.bmj.com/content/11/1...
Read more: gh.bmj.com/content/11/1...
Prevalence, time trends and associated factors of adult overweight and obesity in 36 countries in the WHO African region from 2003 to 2022: a study of 54 WHO STEPS surveys representing 156 million adu...
Background We investigated the prevalence, temporal trends and associated factors of overweight and obesity among adults in the WHO African region.Methods We analysed individual-level data from 54 nat...
gh.bmj.com
January 14, 2026 at 12:35 PM
Dr JP Empana and colleagues @PARCC investigated the prevalence, temporal trends and associated factors of overweight and obesity among adults in the WHO African region.
Read more: gh.bmj.com/content/11/1...
Read more: gh.bmj.com/content/11/1...
Reposted by PARCC
Excited to share our latest work published in @pnas.org! 🎉 Our study shows that blood-borne S1P actively maintains vascular resistance, systemic BP and heart function in mice, with distinct contributions from different circulating S1P pools www.pnas.org/doi/10.1073/... @parcc-inserm.bsky.social
January 13, 2026 at 11:03 AM
Excited to share our latest work published in @pnas.org! 🎉 Our study shows that blood-borne S1P actively maintains vascular resistance, systemic BP and heart function in mice, with distinct contributions from different circulating S1P pools www.pnas.org/doi/10.1073/... @parcc-inserm.bsky.social
Reposted by PARCC
Dans un essai clinique de phase 2, une équipe de l'Inserm montre l’efficacité d’un nouveau traitement pour réduire l'inflammation chronique ou résiduelle qui peut être observée après un syndrome coronaire aigu (SCA).
Lire le communiqué : presse.inserm.fr/syndrome-cor...
Lire le communiqué : presse.inserm.fr/syndrome-cor...
Syndrome coronaire aigu : premiers résultats prometteurs dans la recherche contre la récidive - Salle de presse de l'Inserm
Dans un essai clinique de phase 2, une équipe de recherche de l’Inserm et de l’Université Paris Cité montre l’efficacité d’un nouveau traitement pour réduire cette inflammation après un syndrome coron...
presse.inserm.fr
January 8, 2026 at 4:53 PM
Dans un essai clinique de phase 2, une équipe de l'Inserm montre l’efficacité d’un nouveau traitement pour réduire l'inflammation chronique ou résiduelle qui peut être observée après un syndrome coronaire aigu (SCA).
Lire le communiqué : presse.inserm.fr/syndrome-cor...
Lire le communiqué : presse.inserm.fr/syndrome-cor...
Reposted by PARCC
📢Candidatez à la prochaine édition du Challenge Starthèse qui accompagne les doctorants & jeunes chercheurs dans la valorisation de leurs expérience de thèse, compétences doctorales et travaux de recherche
📆Fermeture des candidatures : 09/02
👉 swll.to/iZT4L
📆Fermeture des candidatures : 09/02
👉 swll.to/iZT4L
January 9, 2026 at 2:15 PM
📢Candidatez à la prochaine édition du Challenge Starthèse qui accompagne les doctorants & jeunes chercheurs dans la valorisation de leurs expérience de thèse, compétences doctorales et travaux de recherche
📆Fermeture des candidatures : 09/02
👉 swll.to/iZT4L
📆Fermeture des candidatures : 09/02
👉 swll.to/iZT4L
Dr E Camerer and colleagues @PARCC uncover an essential role for circulating S1P in maintaining blood pressure and left ventricular systolic function. They also highlight distinct functions for the pools of S1P bound to HDL or to albumin.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 10, 2026 at 1:46 PM
Dr E Camerer and colleagues @PARCC uncover an essential role for circulating S1P in maintaining blood pressure and left ventricular systolic function. They also highlight distinct functions for the pools of S1P bound to HDL or to albumin.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Pr Z Mallat @PARCC and colleagues show that, in patients with acute coronary syndromes, low-dose IL-2 safely increases Treg cell levels and reduces arterial inflammation.
Learn More: www.nature.com/articles/s41...
Learn More: www.nature.com/articles/s41...
Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial - Nature Medicine
In a randomized phase 2 trial in patients with acute coronary syndrome and high levels of the inflammation biomarker C-reactive protein, treatment with low-dose interleukin-2 increased the numbers of ...
www.nature.com
January 8, 2026 at 1:56 PM
Pr Z Mallat @PARCC and colleagues show that, in patients with acute coronary syndromes, low-dose IL-2 safely increases Treg cell levels and reduces arterial inflammation.
Learn More: www.nature.com/articles/s41...
Learn More: www.nature.com/articles/s41...
Reposted by PARCC
A 3D printed guide that reconnects right vagus nerve and heart preserved cardiac function and helped regrow resected nerve in minipigs, with therapeutic potential for thoracic surgery and transplantation.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/49eworw
Learn more in #ScienceTranslationalMedicine: https://scim.ag/49eworw
Reconnecting the vagus nerve to the heart through nerve conduit preserves cardiac function in a minipig model of right cardiac vagotomy
Partial repair of cardiac right vagus nerve using an implantable conduit after vagal resection limits cardiac tissue damage and dysfunction.
scim.ag
December 29, 2025 at 4:00 PM
A 3D printed guide that reconnects right vagus nerve and heart preserved cardiac function and helped regrow resected nerve in minipigs, with therapeutic potential for thoracic surgery and transplantation.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/49eworw
Learn more in #ScienceTranslationalMedicine: https://scim.ag/49eworw
B. Gaye and E. Marijon @PARCC, in collaboration with colleagues from the ERADICATE Consortium (Ending Rheumatic Heart Disease through Advanced Diagnosis, Intervention, Care, Access, Treatment, and Equity), are leading a strategy aimed at eradicating rheumatic heart disease.
doi.org/10.1093/eurh...
doi.org/10.1093/eurh...
Towards the elimination of rheumatic heart disease in Africa and globally: the ERADICATE Consortium
Rheumatic heart disease (RHD) is the leading acquired cardiovascular disease among children, adolescents, and young adults in low- and middle-income countr
doi.org
December 22, 2025 at 1:04 PM
B. Gaye and E. Marijon @PARCC, in collaboration with colleagues from the ERADICATE Consortium (Ending Rheumatic Heart Disease through Advanced Diagnosis, Intervention, Care, Access, Treatment, and Equity), are leading a strategy aimed at eradicating rheumatic heart disease.
doi.org/10.1093/eurh...
doi.org/10.1093/eurh...
A Eichmann and Colleagues @PARCC showed that endothelial ROCK1 and 2 maintain junctional integrity and ensure proper angiogenesis and lumen formation. These data also indicate the need for careful consideration when using ROCK inhibitors in disease settings.
doi.org/10.1093/cvr/...
doi.org/10.1093/cvr/...
Endothelial Rho kinase controls blood vessel integrity and angiogenesis
AbstractAims. The Rho kinases 1 and 2 (ROCK1/2) are serine-threonine specific protein kinases that control actin cytoskeleton dynamics. They are expressed
doi.org
December 18, 2025 at 11:11 AM
A Eichmann and Colleagues @PARCC showed that endothelial ROCK1 and 2 maintain junctional integrity and ensure proper angiogenesis and lumen formation. These data also indicate the need for careful consideration when using ROCK inhibitors in disease settings.
doi.org/10.1093/cvr/...
doi.org/10.1093/cvr/...
Pr D Smadja @PARCC calls to action for Health desinformation. the next battle for public health will be waged not only in hospitals and
laboratories but also in the information spaces where truth competes with virality. It is
time for science to go viral—for the right reason!
laboratories but also in the information spaces where truth competes with virality. It is
time for science to go viral—for the right reason!
December 14, 2025 at 9:05 AM
Pr D Smadja @PARCC calls to action for Health desinformation. the next battle for public health will be waged not only in hospitals and
laboratories but also in the information spaces where truth competes with virality. It is
time for science to go viral—for the right reason!
laboratories but also in the information spaces where truth competes with virality. It is
time for science to go viral—for the right reason!
Reposted by PARCC
Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement.
Lire le communiqué : presse.inserm.fr/decouverte-d...
Lire le communiqué : presse.inserm.fr/decouverte-d...
Découverte de valves au cœur du système lymphatique cardiaque et de leur rôle dans l’insuffisance cardiaque - Salle de presse de l'Inserm
Dans une nouvelle étude, des chercheurs de l’Inserm et de l’Université de Rouen Normandie, en collaboration avec une équipe de l’Université de Wurtzbourg (Allemagne), ont analysé comment le système ly...
presse.inserm.fr
December 12, 2025 at 3:41 PM
Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement.
Lire le communiqué : presse.inserm.fr/decouverte-d...
Lire le communiqué : presse.inserm.fr/decouverte-d...
Pr D Smadja @PARCC and colleagues confirmed the absence of vascular benefit of Hydroxychloroquine (HCQ) treatment, reinforcing evidence against HCQ’s clinical utility in COVID-19 and underscoring the need for alternative endothelial-targeted approaches.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Hydroxychloroquine does not affect endotheliopathy or coagulopathy biomarkers in COVID-19: longitudinal results from the DisCoVeRy randomized trial - Angiogenesis
Background Hydroxychloroquine (HCQ), long used for its immunomodulatory and vasculoprotective properties in autoimmune diseases such as antiphospholipid syndrome, was among the first drugs evaluated f...
link.springer.com
December 13, 2025 at 9:07 AM
Pr D Smadja @PARCC and colleagues confirmed the absence of vascular benefit of Hydroxychloroquine (HCQ) treatment, reinforcing evidence against HCQ’s clinical utility in COVID-19 and underscoring the need for alternative endothelial-targeted approaches.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by PARCC
L’ANR participe au nouvel appel à projets transnational du partenariat européen pour la médecine personnalisée, EP PerMed : "Médecine Personnalisée pour les maladies #cardiovasculaires, #métaboliques et #rénales" #CARMEN2026
📆 10/02/2026 (pré-propositions)
➡ anr.fr/CARMEN2026
📆 10/02/2026 (pré-propositions)
➡ anr.fr/CARMEN2026
December 8, 2025 at 1:48 PM
L’ANR participe au nouvel appel à projets transnational du partenariat européen pour la médecine personnalisée, EP PerMed : "Médecine Personnalisée pour les maladies #cardiovasculaires, #métaboliques et #rénales" #CARMEN2026
📆 10/02/2026 (pré-propositions)
➡ anr.fr/CARMEN2026
📆 10/02/2026 (pré-propositions)
➡ anr.fr/CARMEN2026
Reposted by PARCC
Susan Monarez was fired after less than a month as Director of the CDC for holding the line on scientific integrity
She is part of Nature's 10 - our list of people who shaped science in 2025
go.nature.com/48FnHpx
She is part of Nature's 10 - our list of people who shaped science in 2025
go.nature.com/48FnHpx
The top US health director who stood up for science — and was fired
Susan Monarez is part of Nature’s 10, a list of people who shaped science in 2025.
go.nature.com
December 8, 2025 at 6:17 PM
Susan Monarez was fired after less than a month as Director of the CDC for holding the line on scientific integrity
She is part of Nature's 10 - our list of people who shaped science in 2025
go.nature.com/48FnHpx
She is part of Nature's 10 - our list of people who shaped science in 2025
go.nature.com/48FnHpx
Pr A Loupy team @PARCC has developed a novel FFPE-based molecular diagnostic system which accurately identified cardiac allograft rejection.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Heart allograft rejection: molecular diagnosis using intra-graft targeted gene expression profiling
AbstractBackground and Aims. Tissular gene expression profiling applicable to formalin-fixed, paraffin-embedded (FFPE) endomyocardial biopsies (EMBs) may r
academic.oup.com
December 7, 2025 at 7:12 AM
Pr A Loupy team @PARCC has developed a novel FFPE-based molecular diagnostic system which accurately identified cardiac allograft rejection.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
H Ait-Oufella @PARCC and colleagues review the role of trained immunity in cardiovascular disease.
Trained immunity in cardiovascular disease
Abstract. With innate immunity at the core of the pathophysiology of atherosclerosis, the discovery of new mechanisms of immune cell activation can potenti
academic.oup.com
December 3, 2025 at 8:46 PM
H Ait-Oufella @PARCC and colleagues review the role of trained immunity in cardiovascular disease.
Reposted by PARCC
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer, says Giorgio F. Gilestro
go.nature.com/3McjUsw
go.nature.com/3McjUsw
AI reviewers are here — we are not ready
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer.
go.nature.com
December 3, 2025 at 12:41 PM
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer, says Giorgio F. Gilestro
go.nature.com/3McjUsw
go.nature.com/3McjUsw