Olaya Rendueles
@olayarendueles.bsky.social
Microbial evolution & ecology, focus on surface structures (capsules) and HGT (#plasmids #phages), mostly in #Klebsiella #MicroSky
From Asturias 🇪🇸 living in 🇫🇷 @cnrs.bsky.social
From Asturias 🇪🇸 living in 🇫🇷 @cnrs.bsky.social
Pinned
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
Yay!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
Hard to believe it’s already that time of year!
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
November 19, 2025 at 7:35 AM
Yay!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
Reposted by Olaya Rendueles
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
November 17, 2025 at 10:31 AM
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Reposted by Olaya Rendueles
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:20 PM
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
Reposted by Olaya Rendueles
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
November 11, 2025 at 12:30 PM
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
Very excited to be attending & presenting our work on #Klebsiella biofilm evolution in #ASMBiofilms in Portland!
Biofilm Researchers - Last chance! The standard registration rate expires today (10/9)! Late registration is a bit more expensive. Also, check out our Session VI invited speakers (all speakers can be viewed at the ASM Biofilms Conference website lnkd.in/gkG3Rh2q) #ASMBiofilms
November 7, 2025 at 7:56 PM
Very excited to be attending & presenting our work on #Klebsiella biofilm evolution in #ASMBiofilms in Portland!
Reposted by Olaya Rendueles
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
Reposted by Olaya Rendueles
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community
Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...
www.biorxiv.org
October 12, 2025 at 9:16 PM
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Reposted by Olaya Rendueles
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Olaya Rendueles
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
September 24, 2025 at 2:31 PM
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
Reposted by Olaya Rendueles
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
September 23, 2025 at 6:45 PM
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
📢 Apply to our (2-year) research fellowships at @iast.fr
Join a multidisciplinary, interdisciplinary, transdisciplinary, and indisciplinary group of scholars in Toulouse, walkable/cyclable pink city of chocolatines in the South of France.
Deadline: November 15, 2025.
www.iast.fr/research-fel...
Join a multidisciplinary, interdisciplinary, transdisciplinary, and indisciplinary group of scholars in Toulouse, walkable/cyclable pink city of chocolatines in the South of France.
Deadline: November 15, 2025.
www.iast.fr/research-fel...
Research Fellowships
Each year, IAST invites applications for post-doctoral Research Fellowships, which offer candidates an opportunity to devote themselves full-time to their research at the start of their careers. Fello...
www.iast.fr
September 22, 2025 at 7:54 AM
Acquisition of different rmp alleles can lead to hypervirulence in vivo, but effects are difficult to predict as there is a strong strain-dependency.
@klebclub.bsky.social
@klebclub.bsky.social
The acquisition of rmpADC can increase virulence of classical Klebsiella pneumoniae in the absence of other hypervirulence-associated genes https://www.biorxiv.org/content/10.1101/2025.09.20.677538v1
September 22, 2025 at 7:21 AM
Acquisition of different rmp alleles can lead to hypervirulence in vivo, but effects are difficult to predict as there is a strong strain-dependency.
@klebclub.bsky.social
@klebclub.bsky.social
𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance
September 21, 2025 at 3:43 PM
This promises to be a great read!
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
Evidence for Neolithic acquisition of the high pathogenic island by Escherichia coli followed by recent selection https://www.biorxiv.org/content/10.1101/2025.09.17.676721v1
September 19, 2025 at 6:05 AM
This promises to be a great read!
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
Reposted by Olaya Rendueles
Reposted by Olaya Rendueles
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS
Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature,
but how this anticipatory role promotes adaptation to d...
www.pnas.org
September 19, 2025 at 5:32 AM
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
Reposted by Olaya Rendueles
Super paper from the mighty Mia Winkler, @genomarit.bsky.social and Iren Lohr.
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
A One Health study of Klebsiella pneumoniae species complex plasmids shows a highly diverse and ecologically adaptable plasmidome
Plasmids play a pivotal role in the horizontal gene transfer of antimicrobial resistance (AMR) and virulence determinants among bacteria. Members of the Klebsiella pneumoniae species complex (KpSC) ca...
www.biorxiv.org
September 17, 2025 at 10:12 PM
Super paper from the mighty Mia Winkler, @genomarit.bsky.social and Iren Lohr.
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
Reposted by Olaya Rendueles
Reposted by Olaya Rendueles
Using experimental evolution in host-mimicking media, researchers show that inflammation-like environments limit the loss of quorum sensing—a common adaptation during chronic infections—in Pseudomonas aeruginosa. Learn more in #mSystems: asm.social/2vd
July 16, 2025 at 4:37 PM
Using experimental evolution in host-mimicking media, researchers show that inflammation-like environments limit the loss of quorum sensing—a common adaptation during chronic infections—in Pseudomonas aeruginosa. Learn more in #mSystems: asm.social/2vd
What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
www.biorxiv.org
September 12, 2025 at 12:56 PM
What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻
Reposted by Olaya Rendueles
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails
from unrelated species to transfer their DNA across bacterial hosts. This tail piracy
enables broad dissemination and ...
www.cell.com
September 9, 2025 at 5:05 PM
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
September 9, 2025 at 5:11 AM
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
Asturian@s, Feliz Dia!
Today is always special for me, the festivities to celebrate my region -and it’s patron saint, Covadonga.
I always feel a little pinch in my heart, when I am not there to celebrate, this, yet again, rainy day 😅
#DiaDeAsturias #DiaDeCovadonga #AsturiasParaisoNatural
Today is always special for me, the festivities to celebrate my region -and it’s patron saint, Covadonga.
I always feel a little pinch in my heart, when I am not there to celebrate, this, yet again, rainy day 😅
#DiaDeAsturias #DiaDeCovadonga #AsturiasParaisoNatural
September 8, 2025 at 10:49 AM
Asturian@s, Feliz Dia!
Today is always special for me, the festivities to celebrate my region -and it’s patron saint, Covadonga.
I always feel a little pinch in my heart, when I am not there to celebrate, this, yet again, rainy day 😅
#DiaDeAsturias #DiaDeCovadonga #AsturiasParaisoNatural
Today is always special for me, the festivities to celebrate my region -and it’s patron saint, Covadonga.
I always feel a little pinch in my heart, when I am not there to celebrate, this, yet again, rainy day 😅
#DiaDeAsturias #DiaDeCovadonga #AsturiasParaisoNatural
Reposted by Olaya Rendueles
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
www.science.org
September 6, 2025 at 9:35 AM
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Reposted by Olaya Rendueles
Group size dependent selection for cooperation versus freeloading in collective chemical defence https://www.biorxiv.org/content/10.1101/2025.09.03.672859v1
September 5, 2025 at 6:33 AM
Group size dependent selection for cooperation versus freeloading in collective chemical defence https://www.biorxiv.org/content/10.1101/2025.09.03.672859v1