Olaya Rendueles
@olayarendueles.bsky.social
Microbial evolution & ecology, focus on surface structures (capsules) and HGT (#plasmids #phages), mostly in #Klebsiella #MicroSky
From Asturias 🇪🇸 living in 🇫🇷 @cnrs.bsky.social
From Asturias 🇪🇸 living in 🇫🇷 @cnrs.bsky.social
Pinned
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
Reposted by Olaya Rendueles
Two fully-funded PhD openings in my research group at the University of York.
If you’re excited about viromes, phage biology, Nanopore sequencing, soils and the odd bit of alpine or agricultural field sampling, we’d love to hear from you!
🌱🦠🏔️
tiny.cc/c4pv001
tiny.cc/e4pv001
If you’re excited about viromes, phage biology, Nanopore sequencing, soils and the odd bit of alpine or agricultural field sampling, we’d love to hear from you!
🌱🦠🏔️
tiny.cc/c4pv001
tiny.cc/e4pv001
A Farewell to Arms: The Trade-off Between Growth and Defence in Bacteria (York YBDTP Project) at University of York on FindAPhD.com
PhD Project - A Farewell to Arms: The Trade-off Between Growth and Defence in Bacteria (York YBDTP Project) at University of York, listed on FindAPhD.com
tiny.cc
November 27, 2025 at 5:57 PM
Two fully-funded PhD openings in my research group at the University of York.
If you’re excited about viromes, phage biology, Nanopore sequencing, soils and the odd bit of alpine or agricultural field sampling, we’d love to hear from you!
🌱🦠🏔️
tiny.cc/c4pv001
tiny.cc/e4pv001
If you’re excited about viromes, phage biology, Nanopore sequencing, soils and the odd bit of alpine or agricultural field sampling, we’d love to hear from you!
🌱🦠🏔️
tiny.cc/c4pv001
tiny.cc/e4pv001
Reposted by Olaya Rendueles
🌳Interested in using genomics, metabolomics and/or remote sensing to study the drought tolerance of a majestic tree species? Apply for the PhD position in my group! Deadline: 8 December 2025. 🌳 @spatialgenetics.bsky.social jobs.uzh.ch/job-vacancie...
UZH: PhD position – Drought Tolerance of European beech
We invite applications for a 4-year PhD position working on drought tolerance of European beech using a variety of methodological approaches from remote sensing to genomics and metabolomics.
jobs.uzh.ch
November 26, 2025 at 1:11 PM
🌳Interested in using genomics, metabolomics and/or remote sensing to study the drought tolerance of a majestic tree species? Apply for the PhD position in my group! Deadline: 8 December 2025. 🌳 @spatialgenetics.bsky.social jobs.uzh.ch/job-vacancie...
Reposted by Olaya Rendueles
Pleased to share our recent article in PNAS - a collaboration with @jessicaandreani.bsky.social & Pablo Radicella, with important roles played by many members of each team.
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes | PNAS
Natural genetic transformation is a conserved mechanism of bacterial horizontal gene
transfer, which is directed entirely by the recipient cell and...
www.pnas.org
November 26, 2025 at 7:44 AM
Pleased to share our recent article in PNAS - a collaboration with @jessicaandreani.bsky.social & Pablo Radicella, with important roles played by many members of each team.
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
Reposted by Olaya Rendueles
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...
rdcu.be
November 24, 2025 at 4:08 PM
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Reposted by Olaya Rendueles
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates
-in @natcomms.nature.com
www.nature.com/articles/s41...
-in @natcomms.nature.com
www.nature.com/articles/s41...
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications
Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...
www.nature.com
November 20, 2025 at 11:23 AM
Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates
-in @natcomms.nature.com
www.nature.com/articles/s41...
-in @natcomms.nature.com
www.nature.com/articles/s41...
The @imili-micro.bsky.social project is such a beautiful and necessary initiative!
I am really glad we could contribute.
Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text
- @cbitoulouse.bsky.social
I am really glad we could contribute.
Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text
- @cbitoulouse.bsky.social
Everything you need to explain AMR to family and friends-12:
@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social
@klebclub.bsky.social
@olayarendueles.bsky.social
the ESKAPE Rogues
www.imili-eah.com/prod-api/pro...
@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social
@klebclub.bsky.social
@olayarendueles.bsky.social
the ESKAPE Rogues
www.imili-eah.com/prod-api/pro...
November 20, 2025 at 1:26 PM
The @imili-micro.bsky.social project is such a beautiful and necessary initiative!
I am really glad we could contribute.
Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text
- @cbitoulouse.bsky.social
I am really glad we could contribute.
Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text
- @cbitoulouse.bsky.social
Yay!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
Hard to believe it’s already that time of year!
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more!
@lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.
November 19, 2025 at 7:35 AM
Yay!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
KlebClub is back for its 6th season!
Personally, really happy to reconnect with all other reorganisers after the summer hiatus!
Reposted by Olaya Rendueles
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
November 17, 2025 at 10:31 AM
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Reposted by Olaya Rendueles
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:20 PM
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
Reposted by Olaya Rendueles
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
November 11, 2025 at 12:30 PM
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
@pablolaborda.bsky.social
@crisherencias.bsky.social
How we can fight AMR
imili.org/pdf/Antimicr...
Very excited to be attending & presenting our work on #Klebsiella biofilm evolution in #ASMBiofilms in Portland!
Biofilm Researchers - Last chance! The standard registration rate expires today (10/9)! Late registration is a bit more expensive. Also, check out our Session VI invited speakers (all speakers can be viewed at the ASM Biofilms Conference website lnkd.in/gkG3Rh2q) #ASMBiofilms
November 7, 2025 at 7:56 PM
Very excited to be attending & presenting our work on #Klebsiella biofilm evolution in #ASMBiofilms in Portland!
Reposted by Olaya Rendueles
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
Reposted by Olaya Rendueles
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community
Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...
www.biorxiv.org
October 12, 2025 at 9:16 PM
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Reposted by Olaya Rendueles
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Olaya Rendueles
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
September 24, 2025 at 2:31 PM
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
Reposted by Olaya Rendueles
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
September 23, 2025 at 6:45 PM
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
📢 Apply to our (2-year) research fellowships at @iast.fr
Join a multidisciplinary, interdisciplinary, transdisciplinary, and indisciplinary group of scholars in Toulouse, walkable/cyclable pink city of chocolatines in the South of France.
Deadline: November 15, 2025.
www.iast.fr/research-fel...
Join a multidisciplinary, interdisciplinary, transdisciplinary, and indisciplinary group of scholars in Toulouse, walkable/cyclable pink city of chocolatines in the South of France.
Deadline: November 15, 2025.
www.iast.fr/research-fel...
Research Fellowships
Each year, IAST invites applications for post-doctoral Research Fellowships, which offer candidates an opportunity to devote themselves full-time to their research at the start of their careers. Fello...
www.iast.fr
September 22, 2025 at 7:54 AM
Acquisition of different rmp alleles can lead to hypervirulence in vivo, but effects are difficult to predict as there is a strong strain-dependency.
@klebclub.bsky.social
@klebclub.bsky.social
The acquisition of rmpADC can increase virulence of classical Klebsiella pneumoniae in the absence of other hypervirulence-associated genes https://www.biorxiv.org/content/10.1101/2025.09.20.677538v1
September 22, 2025 at 7:21 AM
Acquisition of different rmp alleles can lead to hypervirulence in vivo, but effects are difficult to predict as there is a strong strain-dependency.
@klebclub.bsky.social
@klebclub.bsky.social
𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance
September 21, 2025 at 3:43 PM
This promises to be a great read!
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
Evidence for Neolithic acquisition of the high pathogenic island by Escherichia coli followed by recent selection https://www.biorxiv.org/content/10.1101/2025.09.17.676721v1
September 19, 2025 at 6:05 AM
This promises to be a great read!
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
“the pathogenicity island was horizontally transferred from Yersinia pestis to E. coli and other Enterobacterales approximatively 4,800 years ago” ⏩️ it then spread to Klebsiella and positively selected over the last 100 yrs ago
Reposted by Olaya Rendueles
Reposted by Olaya Rendueles
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS
Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature,
but how this anticipatory role promotes adaptation to d...
www.pnas.org
September 19, 2025 at 5:32 AM
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
Reposted by Olaya Rendueles
Super paper from the mighty Mia Winkler, @genomarit.bsky.social and Iren Lohr.
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
A One Health study of Klebsiella pneumoniae species complex plasmids shows a highly diverse and ecologically adaptable plasmidome
Plasmids play a pivotal role in the horizontal gene transfer of antimicrobial resistance (AMR) and virulence determinants among bacteria. Members of the Klebsiella pneumoniae species complex (KpSC) ca...
www.biorxiv.org
September 17, 2025 at 10:12 PM
Super paper from the mighty Mia Winkler, @genomarit.bsky.social and Iren Lohr.
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
"We have previously shown that there were relatively few strain-sharing events across ecological niches...plasmid-sharing is considerably more common across niches than strain-sharing. "
www.biorxiv.org/content/10.1...
Reposted by Olaya Rendueles
Reposted by Olaya Rendueles
Using experimental evolution in host-mimicking media, researchers show that inflammation-like environments limit the loss of quorum sensing—a common adaptation during chronic infections—in Pseudomonas aeruginosa. Learn more in #mSystems: asm.social/2vd
July 16, 2025 at 4:37 PM
Using experimental evolution in host-mimicking media, researchers show that inflammation-like environments limit the loss of quorum sensing—a common adaptation during chronic infections—in Pseudomonas aeruginosa. Learn more in #mSystems: asm.social/2vd