Noah Holzleitner
@noahholzleitner.bsky.social
PhD Student at Grünewald Lab (TUM)
🧬Protein Design for CRISPR proteins🧑🏽💻👨🏽🎨
🧬Protein Design for CRISPR proteins🧑🏽💻👨🏽🎨
Reposted by Noah Holzleitner
In any case, I am happy that we were lucky enough to receive funding and am excited to be working on the project. To everyone else who have also been rejected multiple times, I wish you the best of luck—if you are lucky enough to be in a position where you can try again. 13/n; n=13
October 8, 2025 at 8:06 AM
In any case, I am happy that we were lucky enough to receive funding and am excited to be working on the project. To everyone else who have also been rejected multiple times, I wish you the best of luck—if you are lucky enough to be in a position where you can try again. 13/n; n=13
Reposted by Noah Holzleitner
The team is already working to expand the platform’s abilities, including testing in clinically relevant immune and stem cells, and engineering future versions of the system that can rearrange sequences beyond one megabase.
Learn more in the full paper: www.science.org/doi/10.1126/...
Learn more in the full paper: www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 25, 2025 at 6:27 PM
The team is already working to expand the platform’s abilities, including testing in clinically relevant immune and stem cells, and engineering future versions of the system that can rearrange sequences beyond one megabase.
Learn more in the full paper: www.science.org/doi/10.1126/...
Learn more in the full paper: www.science.org/doi/10.1126/...