Nicolas Lux Fawzi
@nicolasluxfawzi.bsky.social
My laboratory uses NMR spectroscopy to examine phase separation and interaction of proteins.
We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain - Nature Communications
RNA-binding protein TDP-43 contains a region forming a dynamic α-helical multimer that accounts for its functional role, evolutionary conservation, and disruption in amyotrophic lateral sclerosis, mak...
www.nature.com
November 27, 2025 at 7:13 PM
We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nicolas Lux Fawzi
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
New preprint from Tongyin Zheng in the lab about how FUS condensates can unfold RNA G-quadruplex structure www.biorxiv.org/content/10.1...
Visualizing TERRA RNA G-quadruplex unfolding in FUS biomolecular condensates
RNA G-quadruplexes (rG4s) are remarkably stable secondary structures with critical regulatory roles in gene expression, RNA metabolism, and telomere maintenance. However, their behavior within cells r...
www.biorxiv.org
October 30, 2025 at 7:35 PM
New preprint from Tongyin Zheng in the lab about how FUS condensates can unfold RNA G-quadruplex structure www.biorxiv.org/content/10.1...
Reposted by Nicolas Lux Fawzi
Fantastic development from AC Immune: 2 promising small molecules for detecting TDP-43 pathology using PET imaging. There's currently no way to detect TDP-43 pathology in living patients with dementia or ALS. Could have a huge impact on future clinical trials.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
October 28, 2025 at 8:46 PM
Fantastic development from AC Immune: 2 promising small molecules for detecting TDP-43 pathology using PET imaging. There's currently no way to detect TDP-43 pathology in living patients with dementia or ALS. Could have a huge impact on future clinical trials.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Nicolas Lux Fawzi
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 11, 2025 at 1:07 PM
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
Reposted by Nicolas Lux Fawzi
Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!
September 3, 2025 at 11:53 AM
Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!
Amazing new work with NMR characterization of ER condensate proteins and elegant cell biology to test the models. congratulations @annaleder.bsky.social
Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 12, 2025 at 5:08 PM
Amazing new work with NMR characterization of ER condensate proteins and elegant cell biology to test the models. congratulations @annaleder.bsky.social
If the paylines go lower, we might need to start getting percentile scores with a decimal point!
August 1, 2025 at 8:30 PM
If the paylines go lower, we might need to start getting percentile scores with a decimal point!
I get emails from people I do not know and wonder "Was this written by AI?"
Given this, will we start ignoring emails more than we already do and place more value on face-to-face and phone conversation (I guess you could get an AI voice to have a conversation for you!), going back in time?
Given this, will we start ignoring emails more than we already do and place more value on face-to-face and phone conversation (I guess you could get an AI voice to have a conversation for you!), going back in time?
August 1, 2025 at 8:28 PM
I get emails from people I do not know and wonder "Was this written by AI?"
Given this, will we start ignoring emails more than we already do and place more value on face-to-face and phone conversation (I guess you could get an AI voice to have a conversation for you!), going back in time?
Given this, will we start ignoring emails more than we already do and place more value on face-to-face and phone conversation (I guess you could get an AI voice to have a conversation for you!), going back in time?
Reposted by Nicolas Lux Fawzi
Over 3 decades of NIH-supported research enabled the FDA approval of Tofersen (Qalsody®), offering new hope for people with SOD1-related ALS. This breakthrough was made possible by unwavering, long-term societal commitment!
Timeline here: www.ninds.nih.gov/about-ninds/...
Timeline here: www.ninds.nih.gov/about-ninds/...
Tofersen (Qalsody®) - Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive and ultimately fatal neurodegenerative disorder that affects motor neurons responsible for initiating and controlling voluntary muscle movement and...
www.ninds.nih.gov
July 25, 2025 at 1:39 PM
Over 3 decades of NIH-supported research enabled the FDA approval of Tofersen (Qalsody®), offering new hope for people with SOD1-related ALS. This breakthrough was made possible by unwavering, long-term societal commitment!
Timeline here: www.ninds.nih.gov/about-ninds/...
Timeline here: www.ninds.nih.gov/about-ninds/...
Reposted by Nicolas Lux Fawzi
Join the Hallegger Lab in Oxford for this highly collaborative project at the interface of molecular modelling, biophysics, biochemistry and stem cell biology funded by My Name'5 Doddie Foundation.
@mndoddie5.bsky.social
Apply before 12 noon on 24 June 2025.
@mndoddie5.bsky.social
Apply before 12 noon on 24 June 2025.
June 21, 2025 at 10:46 AM
Join the Hallegger Lab in Oxford for this highly collaborative project at the interface of molecular modelling, biophysics, biochemistry and stem cell biology funded by My Name'5 Doddie Foundation.
@mndoddie5.bsky.social
Apply before 12 noon on 24 June 2025.
@mndoddie5.bsky.social
Apply before 12 noon on 24 June 2025.
Reposted by Nicolas Lux Fawzi
We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
May 23, 2025 at 3:01 PM
We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social
Reposted by Nicolas Lux Fawzi
On the cover of issue 10: 1,6-hexanediol scrutiny by @nicolasluxfawzi.bsky.social et al
Interferon-induced ADP-ribosylation by PARP14
Nuclear envelope-associated lipid droplets & inflammation
Ancient cyanobacterial proto-circadian clock system reconstruction
...
www.embopress.org/toc/14602075...
Interferon-induced ADP-ribosylation by PARP14
Nuclear envelope-associated lipid droplets & inflammation
Ancient cyanobacterial proto-circadian clock system reconstruction
...
www.embopress.org/toc/14602075...
May 16, 2025 at 8:53 AM
On the cover of issue 10: 1,6-hexanediol scrutiny by @nicolasluxfawzi.bsky.social et al
Interferon-induced ADP-ribosylation by PARP14
Nuclear envelope-associated lipid droplets & inflammation
Ancient cyanobacterial proto-circadian clock system reconstruction
...
www.embopress.org/toc/14602075...
Interferon-induced ADP-ribosylation by PARP14
Nuclear envelope-associated lipid droplets & inflammation
Ancient cyanobacterial proto-circadian clock system reconstruction
...
www.embopress.org/toc/14602075...
Reposted by Nicolas Lux Fawzi
Very excited and grateful to get this opportunity to study new aspects of TDP-43 with
@nicolasluxfawzi.bsky.social
@ayalalab.bsky.social
and Jeetain Mittal!
@nicolasluxfawzi.bsky.social
@ayalalab.bsky.social
and Jeetain Mittal!
April 1, 2025 at 10:27 AM
Very excited and grateful to get this opportunity to study new aspects of TDP-43 with
@nicolasluxfawzi.bsky.social
@ayalalab.bsky.social
and Jeetain Mittal!
@nicolasluxfawzi.bsky.social
@ayalalab.bsky.social
and Jeetain Mittal!
Reposted by Nicolas Lux Fawzi
#preprint Postdoc Nirbhik Acharya used NMR to find three transient helices within intrinsically-disordered regions of shuttle protein Dsk2 -- these interact with STI1. The STI1 is important for phase separation and proteasome condensates in yeast. Comments welcome!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
STI1 domain dynamically engages transient helices in disordered regions to drive self-association and phase separation of yeast ubiquilin Dsk2
Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...
www.biorxiv.org
March 18, 2025 at 12:40 AM
#preprint Postdoc Nirbhik Acharya used NMR to find three transient helices within intrinsically-disordered regions of shuttle protein Dsk2 -- these interact with STI1. The STI1 is important for phase separation and proteasome condensates in yeast. Comments welcome!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nicolas Lux Fawzi
In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
February 28, 2025 at 12:52 PM
In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Reposted by Nicolas Lux Fawzi
Reposted by Nicolas Lux Fawzi
Proud to share:
"Ensemble docking for intrinsically disordered proteins"
from Dartmouth undergrad Anjali Dhar 24' and grad student Tommy Sisk. We present ensemble docking strategies for IDPs that, remarkably, seem to work!
www.biorxiv.org/content/10.1...
Code: github.com/paulrobustel...
"Ensemble docking for intrinsically disordered proteins"
from Dartmouth undergrad Anjali Dhar 24' and grad student Tommy Sisk. We present ensemble docking strategies for IDPs that, remarkably, seem to work!
www.biorxiv.org/content/10.1...
Code: github.com/paulrobustel...
January 31, 2025 at 7:59 PM
Proud to share:
"Ensemble docking for intrinsically disordered proteins"
from Dartmouth undergrad Anjali Dhar 24' and grad student Tommy Sisk. We present ensemble docking strategies for IDPs that, remarkably, seem to work!
www.biorxiv.org/content/10.1...
Code: github.com/paulrobustel...
"Ensemble docking for intrinsically disordered proteins"
from Dartmouth undergrad Anjali Dhar 24' and grad student Tommy Sisk. We present ensemble docking strategies for IDPs that, remarkably, seem to work!
www.biorxiv.org/content/10.1...
Code: github.com/paulrobustel...
Reposted by Nicolas Lux Fawzi
Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling https://www.biorxiv.org/content/10.1101/2024.12.09.627558v1
December 12, 2024 at 3:32 PM
Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling https://www.biorxiv.org/content/10.1101/2024.12.09.627558v1
Reposted by Nicolas Lux Fawzi
Introducing our last #BlackInMicro Rising Star of 2024: Savannah Lewis! Savannah is a PhD Candidate at Stanford University’s School of Medicine, where she focuses on how natural killer cells adapt due to endemic malaria exposure, demonstrating their protective role against
1/4
1/4
November 25, 2024 at 12:00 PM
Introducing our last #BlackInMicro Rising Star of 2024: Savannah Lewis! Savannah is a PhD Candidate at Stanford University’s School of Medicine, where she focuses on how natural killer cells adapt due to endemic malaria exposure, demonstrating their protective role against
1/4
1/4
Reposted by Nicolas Lux Fawzi
Our work on how CPEB4 mis-splicing leads to its aggregation in autism spectrum disorder is now published in Nature.
rdcu.be/d2qjW
I would like to thank the collaborators who joined the team during the revision process as well as the funders who supported us.
rdcu.be/d2qjW
I would like to thank the collaborators who joined the team during the revision process as well as the funders who supported us.
December 4, 2024 at 10:13 PM
Our work on how CPEB4 mis-splicing leads to its aggregation in autism spectrum disorder is now published in Nature.
rdcu.be/d2qjW
I would like to thank the collaborators who joined the team during the revision process as well as the funders who supported us.
rdcu.be/d2qjW
I would like to thank the collaborators who joined the team during the revision process as well as the funders who supported us.
Reposted by Nicolas Lux Fawzi
The two Network for Advanced NMR 1.1 GHz NMR spectrometers are open for use!
1.1 GHz solids at NMRFAM, UW-Madison
1.1 GHz solution at CCRC NMR Facility, UGA
Submit time requests at usnan.nmrhub.org/access-uhf
#NMR #NMRchat
1.1 GHz solids at NMRFAM, UW-Madison
1.1 GHz solution at CCRC NMR Facility, UGA
Submit time requests at usnan.nmrhub.org/access-uhf
#NMR #NMRchat
November 20, 2024 at 10:43 PM
The two Network for Advanced NMR 1.1 GHz NMR spectrometers are open for use!
1.1 GHz solids at NMRFAM, UW-Madison
1.1 GHz solution at CCRC NMR Facility, UGA
Submit time requests at usnan.nmrhub.org/access-uhf
#NMR #NMRchat
1.1 GHz solids at NMRFAM, UW-Madison
1.1 GHz solution at CCRC NMR Facility, UGA
Submit time requests at usnan.nmrhub.org/access-uhf
#NMR #NMRchat
Reposted by Nicolas Lux Fawzi
2nd biennial conference on TDP-43 function and dysfunction in disease"
9-11 September 2025 | Trieste, Italy www.icgeb.org/tdp43-confer...
9-11 September 2025 | Trieste, Italy www.icgeb.org/tdp43-confer...
Arturo Falaschi Conference “2nd biennial conference on TDP-43 function and dysfunction in disease”
Trieste, Italy 9 – 11 September 2025
www.icgeb.org
November 19, 2024 at 2:03 PM
2nd biennial conference on TDP-43 function and dysfunction in disease"
9-11 September 2025 | Trieste, Italy www.icgeb.org/tdp43-confer...
9-11 September 2025 | Trieste, Italy www.icgeb.org/tdp43-confer...