Read more about Alessio's work:

- 2025 Nature paper: www.nature.com/articles/s41...

- 2016 Fellowship: nc3rs.org.uk/our-portfoli...

- 2019 Skills and knowledge transfer award: nc3rs.org.uk/our-portfoli...

- 2023 Studentship: nc3rs.org.uk/our-portfoli...

It has been great to work with Alessio over the years, supporting the development of his alternative model and dissemination to other labs. It is fantastic to see the work recognised by AALAC International through their Global Award, highlighting its strong 3Rs impacts and future potential.

Alessio’s work investigates the role of mitochondria in neuronal ageing and neurodegenerative diseases using a Drosophila model. By taking advantage of the fly’s translucent wings, intracellular interactions can be seen through non-invasive visualisation, replacing the use of some mouse models.

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We hear from two Tech3Rs champions about how they reduced aggression in male CD-1 mice by evaluating different combinations of environmental enrichment and highlight 3Rs papers showcasing simple approaches to increase environmental complexity for improved welfare across different species.

In this issue we share the importance of animal technicians in helping to produce reliable results and speak to Katherine Pye about how her experiences gained as a research technician at the University of Exeter helped to shape her career journey.

While the call primarily focused on human health benefits, our expertise ensured that the animal replacement potential of the work was considered as part of the grant assessment process. We look forward to working with the teams to ensure that the 3Rs impacts of these models are exploited.

The full strategy text is now available: www.gov.uk/government/p...

"The strategy is ambitious and will ensure that the UK maintains its world leading position. The NC3Rs is at the heart of delivering the strategy and I am excited about the opportunities to turn the ambitions into reality."

Dr Vicky Robinson, Chief Executive, NC3Rs

Our Chief Executive Vicky Robinson welcomed the strategy:

"The new government strategy will help to speed up efforts to replace animal research and testing, while also recognising the continued need for high standards of animal welfare where alternative methods currently do not exist."