Summarizing the coordinated roles of the #TumorMicroenvironment & systematic microenvironment in regulating tumor dormancy & reactivation, with insights into clinical strategies for eliminating or sustaining dormancy.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review traces #precancer history and biology, spotlighting dysregulated TGF-β, p53, Wnt, PI3K, and MAPK pathways and a “soil degeneration” hypothesis favoring #microenvironmental dominance with dual-window interventions.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Researchers develop a #PSMA‑targeted self‑assembling nano‑PROTAC that simultaneously degrades AR, AR‑V7, and HSP90 in #CRPC, overcoming resistance to AR inhibitors, achieving potent #antitumor activity with tumor‑specific accumulation.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This #STTT study shows that SLC5A3 in small #ExtracellularVesicles (sEVs) serves as a predictive diagnostic #Biomarker in #PancreaticCancer, suggesting that sEVs function as hubs for producing signalling molecules within target cells.

#OpenAccess: doi.org/10.1038/s413...

Researchers reveal #ferroptosis as a targetable vulnerability in #ChronicLymphocyticLeukemia, showing that BTK inhibition increases iron uptake via TFRC, and combining #ibrutinib with #GPX4 or ACSL1 targeting enhances ferroptosis.

#OpenAccess in #STTT: doi.org/10.1038/s413...

GOOD NEWS! A group of patients with an otherwise incurable form of T‑cell leukemia have seen their cancer driven into REMISSION by an innovative immune therapy known as BE-CAR7. 82% of patients reached deep remission and 64% of patients have now been disease-free and OFF therapy for THREE years.

Join our 2026 Fundamental Biology of Cancer symposium to explore cancer metabolism & the tumour microenvironment. In collaboration with @crukcampanccan.bsky.social.

📍Magdalene College, Cambridge 
📅 24 Feb 2026
Register free ➡️ zurl.co/yf2hw

My first post on here pretty much sums up what it's like to be a working Mum.
Chicken pox has destroyed our week and now waiting for number 2 to inevitably get it 🫠

@academic-chatter.bsky.social #WIASN

How Vaccines Work 🧬🧫🧪🔬💉🥽

Are you over 18, and have you previously been identified, or are you currently classified as gifted and talented? As part of my doctoral research at the University of Bristol, I am investigating the effects of this classification. If you are interested in participating, please scan the QR code!

Public notice:

If you want to read a research article, please don't pay for the paper on the publisher's website. All that money goes to the publisher, we don't get any of it. Instead, contact us. We'll be happy to send you the paper :-).

@academic-chatter.bsky.social #OpenScience

📢 Fully-funded 4-year MRC DiMeN PhD opportunity in our lab.

🔬 Exciting cancer cell biology collab with @maiblab.bsky.social & Liz Smythe @mcb-sheffield.bsky.social to use recombinant biosensors to image active KRAS in #pancreaticcancer

👇Apply by 4th Dec

www.findaphd.com/phds/project...