Sini Nagpal
nagpalsini.bsky.social
Sini Nagpal
@nagpalsini.bsky.social
Postdoctoral Fellow with Dr. Greg Gibson, Center for Integrative Genomics, Georgia Tech, Atlanta, GA
PhD Bioinformatics (Statistical Genetics) | MS Bioinformatics @GeorgiaTech
https://sininagpal.wixsite.com/snagpal
Reposted by Sini Nagpal
Heading to Boston for the American Society of Human Genetics #ASHG25 @geneticssociety.bsky.social! Excited to present our work on how pervasive exposure-by-polygenic score interactions can inform more effective clinical and behavioral interventions. #B1070W

www.medrxiv.org/content/10.1...
Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit
The transferability of polygenic scores across population groups is a major concern with respect to the equitable clinical implementation of genomic medicine. Since genetic associations are identified...
www.medrxiv.org
October 13, 2025 at 4:11 PM
Reposted by Sini Nagpal
Pleased to have contributed to this paper out at @nature.com today from @vw1234.bsky.social and Yira (Xinhe) Zhang showing that the common variant contribution to autism varies substantially by age of diagnosis www.nature.com/articles/s41.... Critical for understanding heterogeneity in autism.
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
www.nature.com
October 2, 2025 at 2:46 PM
Reposted by Sini Nagpal
The age that autism is diagnosed may partly reflect underlying biological and developmental differences among individuals with autism, according to a study in Nature. go.nature.com/4gQ5gSV 🧬 🧪
October 1, 2025 at 10:43 PM
Excited to share our latest manuscript on "Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit" with Greg Gibson (@genomestake),
https://www.medrxiv.org/content/10.1101/2024.07.29.24311065v1 [1/9]
Dual exposure-by-polygenic score interactions highlight d...
The transferability of polygenic scores across population...
www.medrxiv.org
May 5, 2025 at 10:46 PM
Lots of interesting discussions on polygenic risk scores and their implementation @HarvardPqg - Diversity in Genetics and Genomics.
#polygenicriskscores #prs #environment #diversity #biobanks #precisionmedicine
May 5, 2025 at 10:46 PM
This year has been special - my doctoral graduation ceremony with my advisor and mentor, Greg Gibson (@genomestake ) and my family 🙂
May 5, 2025 at 10:46 PM
Honored to be selected as the Postdoctoral Semifinalist for 2022 Charles J. Epstein Awards for Excellence in Human Genetics Research for #ASHGef="/hashtag/ASHG22" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#ASHG22! Plus, our abstract has been selected as the Reviewer's Choice abstract 😀 #ASHG @GeneticsSociety...
May 5, 2025 at 10:46 PM
Very happy and excited to share the final study of my PhD out in @MolBioEvol. All results from this study can be explored through our Rshiny: https://canalization-gibsonlab.shinyapps.io/rshiny/
https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msac053/6547257
May 5, 2025 at 10:46 PM
Reading @kph3k's wonderfully written "The Genetic Lottery", while beginning the journey to write my PhD thesis🙂
Any tips and suggestions as I embark on this journey are welcome!
May 5, 2025 at 10:46 PM
May 5, 2025 at 10:46 PM
Excited to share our work out in the @AJHGNews on "Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression" https://www.cell.com/ajhg/fulltext/S0002-9297(21)00296-2#secsectitle0075
May 5, 2025 at 10:46 PM
Check out Greg Gibson's @genomestake interview with 11Alive about surveillance testing on GT campus. This is a great effort, congratulations !
https://www.11alive.com/video/news/health/coronavirus/georgia-tech-covid-testing/85-c6b7c338-8d22-452b-9828-13d8b22d36e8
Georgia Tech's testing program proof we can cut COVID-19 ...
As the state's COVID-19 numbers started to fall, so did t...
www.11alive.com
May 5, 2025 at 10:46 PM
All set for the Summer Institute of Statistical Genetics at University of Washington, Seattle!
Module 1: Bayesian Statistics for Genetics by Jon Wakefield and Ken Rice @UWBiostat #SISG #statgen
May 5, 2025 at 10:46 PM
I'm excited for #DDW19 on May 18-21, 2019. Join me in San Diego, CA for DDW's 50th anniversary event! https://app.ingo.me/q/grita .
Digestive Disease Week® (DDW) 2019
app.ingo.me
May 5, 2025 at 10:51 PM
TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits: https://www.biorxiv.org/content/biorxiv/early/2018/12/28/507525.full.pdf
May 5, 2025 at 10:51 PM