@myosinactncrazy.bsky.social
#1 molecular motor,
cytoskeletal motors, cytoskeletal filaments, filament dynamics, cell migration, mechanobiology, morphogenesis
cytoskeletal motors, cytoskeletal filaments, filament dynamics, cell migration, mechanobiology, morphogenesis
Reposted
Today’s data drop from our alpha-actinin-4 paper!
1A: Cardiac myocytes don’t just express muscle alpha-actinin (ACTN2)… they also express ACTN4; a “non-muscle” paralog. 1B: ACTN4 is sitting right at the Z-disc, shoulder-to-shoulder with ACTN2.
www.ahajournals.org/doi/10.1161/...
1A: Cardiac myocytes don’t just express muscle alpha-actinin (ACTN2)… they also express ACTN4; a “non-muscle” paralog. 1B: ACTN4 is sitting right at the Z-disc, shoulder-to-shoulder with ACTN2.
www.ahajournals.org/doi/10.1161/...
November 27, 2025 at 3:41 PM
Today’s data drop from our alpha-actinin-4 paper!
1A: Cardiac myocytes don’t just express muscle alpha-actinin (ACTN2)… they also express ACTN4; a “non-muscle” paralog. 1B: ACTN4 is sitting right at the Z-disc, shoulder-to-shoulder with ACTN2.
www.ahajournals.org/doi/10.1161/...
1A: Cardiac myocytes don’t just express muscle alpha-actinin (ACTN2)… they also express ACTN4; a “non-muscle” paralog. 1B: ACTN4 is sitting right at the Z-disc, shoulder-to-shoulder with ACTN2.
www.ahajournals.org/doi/10.1161/...
Reposted
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
November 27, 2025 at 2:14 PM
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
Reposted
📣 2nd meeting of France-BioImaging Mechanobiology Working Group
📆 March 26-27th, 2026
📍Institut Jacques Monod, Buffon amphitheater
Registration are open until December 31st 🔗 buff.ly/cVzaoId
@upcite.bsky.social @sbcf.bsky.social @gdraqv.bsky.social @cnrsbiologie.bsky.social @psl-univ.bsky.social
📆 March 26-27th, 2026
📍Institut Jacques Monod, Buffon amphitheater
Registration are open until December 31st 🔗 buff.ly/cVzaoId
@upcite.bsky.social @sbcf.bsky.social @gdraqv.bsky.social @cnrsbiologie.bsky.social @psl-univ.bsky.social
2nd meeting of France-BioImaging Mechanobiology Working Group
The second meeting of the FBI Mechanobiology WG will take place on the 26 and 27 of March 2026 at the Institut de Biologie Paris Seine and the Institut Jacques Monod in Paris. The programme will in…
france-bioimaging.org
November 27, 2025 at 3:26 PM
📣 2nd meeting of France-BioImaging Mechanobiology Working Group
📆 March 26-27th, 2026
📍Institut Jacques Monod, Buffon amphitheater
Registration are open until December 31st 🔗 buff.ly/cVzaoId
@upcite.bsky.social @sbcf.bsky.social @gdraqv.bsky.social @cnrsbiologie.bsky.social @psl-univ.bsky.social
📆 March 26-27th, 2026
📍Institut Jacques Monod, Buffon amphitheater
Registration are open until December 31st 🔗 buff.ly/cVzaoId
@upcite.bsky.social @sbcf.bsky.social @gdraqv.bsky.social @cnrsbiologie.bsky.social @psl-univ.bsky.social
Effect of Load on Non-Muscle Myosin 2 Paralog Filaments in a Biomimetic Contractile Actin Array
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Effect of Load on Non‐Muscle Myosin 2 Paralog Filaments in a Biomimetic Contractile Actin Array
The main paralogs of non-muscle myosin 2 are studied on a micropatterned array of anti-parallel actin filaments. This sarcomere-like platform reveals myosin's load-dependent behavior, and the resulti...
onlinelibrary.wiley.com
November 27, 2025 at 12:59 PM
Effect of Load on Non-Muscle Myosin 2 Paralog Filaments in a Biomimetic Contractile Actin Array
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted
Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!!
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal
imageimageDynein-2 is a motor protein essential for retrograde intraflagellar transport (IFT)
on the A-tubule of ciliary doublet microtubules. Here, biochemical and cryo-ET analyses
demonstrate that d...
www.embopress.org
November 26, 2025 at 4:57 PM
Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!!
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Reposted
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:41 PM
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
interesting work revealing differences between evolutionary distant actins!
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts
Actin is an essential cytoskeletal protein that is extremely well conserved across the tree of life. Similarities and differences in the way actin from different species self-assembles into filaments ...
www.biorxiv.org
November 22, 2025 at 1:31 PM
interesting work revealing differences between evolutionary distant actins!
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
"..... ADP-actin filaments depolymerize faster and are mechanically more flexible in Saccharomyces cerevisiae compared to Schizosaccharomyces pombe. "
www.biorxiv.org/content/10.1...
Reposted
Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport: iScience www.cell.com/iscience/ful...
Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport
Inside cells, molecular motors transport cargo through a highly crowded cytoplasmic
environment. While such an environment is assumed to hinder transport, its precise
effect remains unclear. Here, we ...
www.cell.com
November 22, 2025 at 1:39 AM
Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport: iScience www.cell.com/iscience/ful...
Filament transport supports contractile steady states of actin
networks.
www.biorxiv.org/content/10.1...
networks.
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 21, 2025 at 1:22 AM
Filament transport supports contractile steady states of actin
networks.
www.biorxiv.org/content/10.1...
networks.
www.biorxiv.org/content/10.1...
Reposted
Check out our newest work! This is a story on how to get selectivity in binders - both isoform and site selectivity. Read the paper or enjoy this brief Skytorial of what we did!
www.biorxiv.org/content/10.1...
1/n
www.biorxiv.org/content/10.1...
1/n
PANCS-spec-Binders: A system for rapidly discovering isoform- or epitope-specific binders
Proteins that bind to a target protein of interest, termed "binders," are essential components of biological research reagents and therapeutics. Target proteins present multiple binding surfaces with ...
www.biorxiv.org
November 19, 2025 at 6:10 PM
Check out our newest work! This is a story on how to get selectivity in binders - both isoform and site selectivity. Read the paper or enjoy this brief Skytorial of what we did!
www.biorxiv.org/content/10.1...
1/n
www.biorxiv.org/content/10.1...
1/n
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
rupress.org/jcb/article-...
rupress.org/jcb/article-...
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
Joly and Pintard uncover how the enzyme Katanin avoids wasting energy during microtubule remodeling. Their findings reveal how Katanin couples activation t
rupress.org
November 20, 2025 at 4:57 AM
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
rupress.org/jcb/article-...
rupress.org/jcb/article-...
awesome postdoc opportunity alert!
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
November 19, 2025 at 5:06 AM
awesome postdoc opportunity alert!
Reposted
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage
Myosin 2-dependent actin contractility—the force that powers cell division and migration
in animals, fungi, and other Amorphea—had been previously unknown outside this single
eukaryotic group. Guest e...
www.cell.com
November 17, 2025 at 5:19 PM
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Reposted
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
Class-I myosin responds to change in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 13, 2025 at 1:02 PM
Class-I myosin responds to change in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Myosin-19 and Miro Regulate Mitochondria–Endoplasmic Reticulum Contacts and Mitochondria Inner Membrane Architecture
www.mdpi.com/2073-4409/14...
www.mdpi.com/2073-4409/14...
www.mdpi.com
November 13, 2025 at 12:22 PM
Myosin-19 and Miro Regulate Mitochondria–Endoplasmic Reticulum Contacts and Mitochondria Inner Membrane Architecture
www.mdpi.com/2073-4409/14...
www.mdpi.com/2073-4409/14...
