Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

“Looking Beyond Academia” | Feb 9 | @uni-freiburg.de

One of the most nerve-wracking questions for PhD students: What comes after the doctorate? To ease the transition into the next career phase, we invite you to join the IMPRS @sgbmfreiburg.bsky.social #Career Evening.

Register: s.gwdg.de/yjlAXo

Happy holidays from the @flurylab.bsky.social!🎉 A year with a lot of firsts: first PhD students, first Postdoc, first grant & first farewells - and a first lab move, too! Thanks to my amazing team for the hard work & curiosity!💪🧐👥 Can't wait to tackle more firsts (& seconds) in the coming year(s)!🙌🤩

Science off the bench! 🥳
Here's to our beautiful Christmas wreath — creatively adorned with colorful Falcon caps, mini Eppis, and, of course, our signature artistic yeast plates. 😎🎨

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

Fabulous post by @randomwalker.bsky.social & Sayash raising the same concern many of us have about whether we're on the right track with how we're using AI for science. Everyone should read it, take a deep breath & think through the implications.

www.aisnakeoil.com/p/could-ai-s...

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

An AI model developed by Google DeepMind could help scientists make sense of the non-protein-coding part of the genome

https://go.nature.com/4llASRk

3D bioprinting innovation and the patentability hurdle - @uqlaw.bsky.social go.nature.com/4dsBr9i

Introducing FISHnet, a graph-theory-based method for sensitive and specific identification of chromatin domains from single-cell sequential Oligopaints data.

www.nature.com/articles/s41...

It has been bittersweet last week, when we bid farewell to Pedro and Prasanthi who are embarking on a new adventure!🥹 Thanks a lot for all the hard work and high spirit!🙏