MS Lee Lab
@msleelab.bsky.social
A research group interested in proteomics, peptidomics, and PTMomics in neuro-diseases📍TU_Muenchen
| CLINSPECT-M consortium | opinions are my own (Chien-Yun)
| CLINSPECT-M consortium | opinions are my own (Chien-Yun)
We of course couldn’t let that slip and developed a method:
✅ compatible with tandem MS
✅ strong enrichment efficiency
✅ uses commercial reagents, works in tubes + 96-well plates
We hope it becomes your new favorite for hunting this tiny PTM 🔥
#citrullination #proteomics #ptms
✅ compatible with tandem MS
✅ strong enrichment efficiency
✅ uses commercial reagents, works in tubes + 96-well plates
We hope it becomes your new favorite for hunting this tiny PTM 🔥
#citrullination #proteomics #ptms
April 28, 2025 at 12:50 PM
We of course couldn’t let that slip and developed a method:
✅ compatible with tandem MS
✅ strong enrichment efficiency
✅ uses commercial reagents, works in tubes + 96-well plates
We hope it becomes your new favorite for hunting this tiny PTM 🔥
#citrullination #proteomics #ptms
✅ compatible with tandem MS
✅ strong enrichment efficiency
✅ uses commercial reagents, works in tubes + 96-well plates
We hope it becomes your new favorite for hunting this tiny PTM 🔥
#citrullination #proteomics #ptms
Our Motif-Specific mAbs...
✔ Motif-specific (and sensitive)
✔ Minimal homocitrullination cross-reactivity
✔ Works in real samples
Also? Some commercial Abs didn’t stand a chance. 😉
To try? We’re making ours openly available to support the citrullination community!
#Citrullination #Antibodies #PTMs
✔ Motif-specific (and sensitive)
✔ Minimal homocitrullination cross-reactivity
✔ Works in real samples
Also? Some commercial Abs didn’t stand a chance. 😉
To try? We’re making ours openly available to support the citrullination community!
#Citrullination #Antibodies #PTMs
March 31, 2025 at 9:30 AM
Our Motif-Specific mAbs...
✔ Motif-specific (and sensitive)
✔ Minimal homocitrullination cross-reactivity
✔ Works in real samples
Also? Some commercial Abs didn’t stand a chance. 😉
To try? We’re making ours openly available to support the citrullination community!
#Citrullination #Antibodies #PTMs
✔ Motif-specific (and sensitive)
✔ Minimal homocitrullination cross-reactivity
✔ Works in real samples
Also? Some commercial Abs didn’t stand a chance. 😉
To try? We’re making ours openly available to support the citrullination community!
#Citrullination #Antibodies #PTMs
We developed a deep learning model to predict MS2 spectra of citrullinated peptides, improving site ID by up to 14x in human tissue proteomes with high precision!
Pipeline available via oktoberfest: github.com/wilhelm-lab/...
Pipeline available via oktoberfest: github.com/wilhelm-lab/...
oktoberfest/tutorials at development · wilhelm-lab/oktoberfest
Rescoring and spectral library generation pipeline for proteomics. - wilhelm-lab/oktoberfest
github.com
February 6, 2025 at 5:36 AM
We developed a deep learning model to predict MS2 spectra of citrullinated peptides, improving site ID by up to 14x in human tissue proteomes with high precision!
Pipeline available via oktoberfest: github.com/wilhelm-lab/...
Pipeline available via oktoberfest: github.com/wilhelm-lab/...