MS Lee Lab
@msleelab.bsky.social
A research group interested in proteomics, peptidomics, and PTMomics in neuro-diseases📍TU_Muenchen
| CLINSPECT-M consortium | opinions are my own (Chien-Yun)
| CLINSPECT-M consortium | opinions are my own (Chien-Yun)
Pinned
MS Lee Lab
@msleelab.bsky.social
· Feb 6
Deep Learning Enhances Precision of Citrullination Identification in Human and Plant Tissue Proteomes
Citrullination is a critical yet understudied post-translational modification (PTM)
implicated in various biological processes. Exploring its role in health and disease
requires a comprehensive unders...
www.mcponline.org
Kicking off the new year strong! Prosit-Cit is officially online!🍻 Check it out: www.mcponline.org/article/S153...
#DeepLearning #Citrullination #Bioinformatics
#DeepLearning #Citrullination #Bioinformatics
Hello Toronto! 🇨🇦 The terrific TUM team is on fire today at #HUPO2025!
Don’t miss our postdoc Andreas presenting his peptidome study on 2,000+ plasma samples with unprecedented depth and robustness — catch him at poster session PV.02.065!
#peptidome #proteomics #TUM #HUPO2025 #TTTT
Don’t miss our postdoc Andreas presenting his peptidome study on 2,000+ plasma samples with unprecedented depth and robustness — catch him at poster session PV.02.065!
#peptidome #proteomics #TUM #HUPO2025 #TTTT
Hello Toronto!🍁The Terrific TUM Team is happy to be attending #HUPO2025. Kusterlab, Wilhelmlab and Leelab have a diverse set of presentations for you that we can't wait to share 🤓.
We're excited to spend the next days reuniting with old friends and making new connections. See you there!
We're excited to spend the next days reuniting with old friends and making new connections. See you there!
November 11, 2025 at 3:38 PM
Hello Toronto! 🇨🇦 The terrific TUM team is on fire today at #HUPO2025!
Don’t miss our postdoc Andreas presenting his peptidome study on 2,000+ plasma samples with unprecedented depth and robustness — catch him at poster session PV.02.065!
#peptidome #proteomics #TUM #HUPO2025 #TTTT
Don’t miss our postdoc Andreas presenting his peptidome study on 2,000+ plasma samples with unprecedented depth and robustness — catch him at poster session PV.02.065!
#peptidome #proteomics #TUM #HUPO2025 #TTTT
Reposted by MS Lee Lab
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications
Protein function is dynamically modulated by post-translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. ...
doi.org
October 20, 2025 at 7:07 AM
Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics!
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets.
Check it out here: doi.org/10.1002/pmic...
Another new preprint is out — with it, a proteome-wide solution to study citrullination at scale!
www.biorxiv.org/content/10.1...
If you’ve been following our journey into one of the trickiest PTMs (citrullination), you might be thinking... what about enrichment before MS?
www.biorxiv.org/content/10.1...
If you’ve been following our journey into one of the trickiest PTMs (citrullination), you might be thinking... what about enrichment before MS?
High-throughput chemical proteomics workflow for profiling protein citrullination dynamics
Citrullination is a post-translational modification implicated in autoimmune and inflammatory diseases, yet its low abundance and lack of effective enrichment tools have limited proteome-wide analysis...
www.biorxiv.org
April 28, 2025 at 12:50 PM
Another new preprint is out — with it, a proteome-wide solution to study citrullination at scale!
www.biorxiv.org/content/10.1...
If you’ve been following our journey into one of the trickiest PTMs (citrullination), you might be thinking... what about enrichment before MS?
www.biorxiv.org/content/10.1...
If you’ve been following our journey into one of the trickiest PTMs (citrullination), you might be thinking... what about enrichment before MS?
New preprint! 🎉
www.biorxiv.org/content/10.1...
If you've ever tried detecting citrullinated proteins, you know the pain—most pan-citrullination antibodies are either useless, cross-reactive, or heartbreakingly bad. 💔😭
I tested them. I suffered. I cried. So we made our own.
www.biorxiv.org/content/10.1...
If you've ever tried detecting citrullinated proteins, you know the pain—most pan-citrullination antibodies are either useless, cross-reactive, or heartbreakingly bad. 💔😭
I tested them. I suffered. I cried. So we made our own.
Development of Motif-Specific Monoclonal Antibodies for Global Protein Citrullination Detection with Minimal Cross-Reactivity to Homocitrullination
Protein citrullination, a post-translational modification (PTM) catalyzed by peptidylarginine deiminases (PADs), plays critical roles in biological processes such as immunity, gene regulation, and inf...
www.biorxiv.org
March 31, 2025 at 9:30 AM
New preprint! 🎉
www.biorxiv.org/content/10.1...
If you've ever tried detecting citrullinated proteins, you know the pain—most pan-citrullination antibodies are either useless, cross-reactive, or heartbreakingly bad. 💔😭
I tested them. I suffered. I cried. So we made our own.
www.biorxiv.org/content/10.1...
If you've ever tried detecting citrullinated proteins, you know the pain—most pan-citrullination antibodies are either useless, cross-reactive, or heartbreakingly bad. 💔😭
I tested them. I suffered. I cried. So we made our own.
Reposted by MS Lee Lab
🚀 Exciting news from our lab! Our latest paper has been featured on the cover of @molsystbiol.org - "Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response" by Höfer et al.! 🧬🎉 doi.org/10.1038/s44320-025-00085-6 (1/4)
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response | Molecular Systems Biology
imageimagePhosphoproteomics unveils the mode of action of clinical ATR inhibitors and explains
their synergy with Gemcitabine in pancreatic cancer cells. Viability screening of 146 targeted drugs ide...
doi.org
March 4, 2025 at 4:06 PM
🚀 Exciting news from our lab! Our latest paper has been featured on the cover of @molsystbiol.org - "Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response" by Höfer et al.! 🧬🎉 doi.org/10.1038/s44320-025-00085-6 (1/4)
Reposted by MS Lee Lab
🎉 We're happy to announce that our latest project was published in @naturecomms.bsky.social this week: PTMNavigator, a #bioinformatics web platform for in-depth analysis of post-translational modification (PTM) perturbation datasets.
📄 doi.org/10.1038/s414... (1/6)
📄 doi.org/10.1038/s414... (1/6)
PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways - Nature Communications
Post-translational modifications are important regulators of cellular pathways, but our understanding of these processes is limited. Here, the authors present a web tool that integrates various databa...
doi.org
January 10, 2025 at 2:20 PM
🎉 We're happy to announce that our latest project was published in @naturecomms.bsky.social this week: PTMNavigator, a #bioinformatics web platform for in-depth analysis of post-translational modification (PTM) perturbation datasets.
📄 doi.org/10.1038/s414... (1/6)
📄 doi.org/10.1038/s414... (1/6)
Kicking off the new year strong! Prosit-Cit is officially online!🍻 Check it out: www.mcponline.org/article/S153...
#DeepLearning #Citrullination #Bioinformatics
#DeepLearning #Citrullination #Bioinformatics
Deep Learning Enhances Precision of Citrullination Identification in Human and Plant Tissue Proteomes
Citrullination is a critical yet understudied post-translational modification (PTM)
implicated in various biological processes. Exploring its role in health and disease
requires a comprehensive unders...
www.mcponline.org
February 6, 2025 at 5:36 AM
Kicking off the new year strong! Prosit-Cit is officially online!🍻 Check it out: www.mcponline.org/article/S153...
#DeepLearning #Citrullination #Bioinformatics
#DeepLearning #Citrullination #Bioinformatics