Mitchell R. Vollger
@mrvollger.bsky.social
Pinned
Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com
Reposted by Mitchell R. Vollger
Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.
Influence of cis-regulatory elements on regulatory divergence in human segmental duplications https://www.biorxiv.org/content/10.1101/2025.10.03.680410v1
October 7, 2025 at 2:31 AM
Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.
Reposted by Mitchell R. Vollger
More youtube videos coming soon to www.youtube.com/BenLangmead! New recording setup. I've got a couple videos in the editing phase and hope to keep up a rhythm of 1 new video per week.
September 9, 2025 at 3:25 PM
More youtube videos coming soon to www.youtube.com/BenLangmead! New recording setup. I've got a couple videos in the editing phase and hope to keep up a rhythm of 1 new video per week.
@uwmedicine.bsky.social what is this? Trying to get your patients and employees with insurance to pay for full medical bills during check in before billing insurance… Disappointing and wrong.
August 17, 2025 at 4:20 PM
@uwmedicine.bsky.social what is this? Trying to get your patients and employees with insurance to pay for full medical bills during check in before billing insurance… Disappointing and wrong.
Reposted by Mitchell R. Vollger
Congratulations to @benlangmead.bsky.social on his promotion to full professor! 🎉 Prof. Langmead is recognized across the computational and life sciences fields for his innovative methods helping to transform how biomedical researchers and other life scientists access and use DNA sequencing data. 🧬
July 22, 2025 at 6:52 PM
Congratulations to @benlangmead.bsky.social on his promotion to full professor! 🎉 Prof. Langmead is recognized across the computational and life sciences fields for his innovative methods helping to transform how biomedical researchers and other life scientists access and use DNA sequencing data. 🧬
Reposted by Mitchell R. Vollger
Thrilled that our study on human gene duplications and brain evolution is out! It was a true labor of love, with special shout-outs to my co-first author @jmuribescr.bsky.social and my PhD mentor @mydennis.bsky.social. Huge thanks as well to @aidaandres.bsky.social for all the popgen wisdom!
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
July 21, 2025 at 5:33 PM
Thrilled that our study on human gene duplications and brain evolution is out! It was a true labor of love, with special shout-outs to my co-first author @jmuribescr.bsky.social and my PhD mentor @mydennis.bsky.social. Huge thanks as well to @aidaandres.bsky.social for all the popgen wisdom!
Reposted by Mitchell R. Vollger
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
July 21, 2025 at 4:26 PM
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
Reposted by Mitchell R. Vollger
How it started vs. How it's going #Tenured
Grateful to all those who've been a part of this journey so far. But the fun is just getting started 💪
Curious to find out just what this privilege of tenure can enable. Let's see how we can put it to the test. Feel free to share ideas 😉
#AcademicSky
Grateful to all those who've been a part of this journey so far. But the fun is just getting started 💪
Curious to find out just what this privilege of tenure can enable. Let's see how we can put it to the test. Feel free to share ideas 😉
#AcademicSky
July 8, 2025 at 1:14 AM
How it started vs. How it's going #Tenured
Grateful to all those who've been a part of this journey so far. But the fun is just getting started 💪
Curious to find out just what this privilege of tenure can enable. Let's see how we can put it to the test. Feel free to share ideas 😉
#AcademicSky
Grateful to all those who've been a part of this journey so far. But the fun is just getting started 💪
Curious to find out just what this privilege of tenure can enable. Let's see how we can put it to the test. Feel free to share ideas 😉
#AcademicSky
Reposted by Mitchell R. Vollger
Some personal news: amid everything going on, I’ve been promoted to Professor. I am so deeply grateful to all of the past and present members of the lab, who allowed me to be a part of their journey. I am so honored to call all of you my colleagues.
July 3, 2025 at 11:07 PM
Some personal news: amid everything going on, I’ve been promoted to Professor. I am so deeply grateful to all of the past and present members of the lab, who allowed me to be a part of their journey. I am so honored to call all of you my colleagues.
Reposted by Mitchell R. Vollger
🧬🧪Fiber-seq was developed and originally published by Andrew Stergachis (now at @uwdeptmedicine.bsky.social) in 2020.
It's a very cool method for adding chromatin accessibility data to native LRS experiments.
You should definitely check out the original paper: www.science.org/doi/10.1126/...
It's a very cool method for adding chromatin accessibility data to native LRS experiments.
You should definitely check out the original paper: www.science.org/doi/10.1126/...
Single-molecule regulatory architectures captured by chromatin fiber sequencing
Fiber-seq translates single-molecule chromatin stencils into a readout of the primary architecture of chromatin.
www.science.org
June 18, 2025 at 8:45 PM
🧬🧪Fiber-seq was developed and originally published by Andrew Stergachis (now at @uwdeptmedicine.bsky.social) in 2020.
It's a very cool method for adding chromatin accessibility data to native LRS experiments.
You should definitely check out the original paper: www.science.org/doi/10.1126/...
It's a very cool method for adding chromatin accessibility data to native LRS experiments.
You should definitely check out the original paper: www.science.org/doi/10.1126/...
Reposted by Mitchell R. Vollger
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
apnews.com/article/nih-...
June 10, 2025 at 4:10 AM
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3
apnews.com/article/nih-...
apnews.com/article/nih-...
Reposted by Mitchell R. Vollger
You may be excited, @mrvollger.bsky.social, but we are even more so! I can't wait to be your colleague!
Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com
June 5, 2025 at 8:19 PM
You may be excited, @mrvollger.bsky.social, but we are even more so! I can't wait to be your colleague!
Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com
June 5, 2025 at 2:15 PM
Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com
Reposted by Mitchell R. Vollger
Had the privilege to also see the magnificent session S10 - on the non-coding genome.
Again top-notch science with great presentations and style of bring complex matters to a broad audience! What a treat!
Thanks @mrvollger.bsky.social; @elfridedebaere.bsky.social and Musa Mhlanga @eshg.bsky.social
Again top-notch science with great presentations and style of bring complex matters to a broad audience! What a treat!
Thanks @mrvollger.bsky.social; @elfridedebaere.bsky.social and Musa Mhlanga @eshg.bsky.social
May 26, 2025 at 4:34 AM
Had the privilege to also see the magnificent session S10 - on the non-coding genome.
Again top-notch science with great presentations and style of bring complex matters to a broad audience! What a treat!
Thanks @mrvollger.bsky.social; @elfridedebaere.bsky.social and Musa Mhlanga @eshg.bsky.social
Again top-notch science with great presentations and style of bring complex matters to a broad audience! What a treat!
Thanks @mrvollger.bsky.social; @elfridedebaere.bsky.social and Musa Mhlanga @eshg.bsky.social
Reposted by Mitchell R. Vollger
In work led by @lalli.bsky.social, we present recombination maps and a diverse haplotype reference panel (1000 Genomes Project) for the T2T-CHM13 human reference genome. These resources improve the accuracy of phasing and imputation, especially around common CNVs. www.biorxiv.org/content/10.1...
A T2T-CHM13 recombination map and globally diverse haplotype reference panel improves phasing and imputation
The T2T-CHM13 complete human reference genome contains ~200 Mb of newly resolved sequence, improving read mapping and variant calling compared to GRCh38. However, the benefits of using complete refere...
www.biorxiv.org
March 3, 2025 at 2:24 PM
In work led by @lalli.bsky.social, we present recombination maps and a diverse haplotype reference panel (1000 Genomes Project) for the T2T-CHM13 human reference genome. These resources improve the accuracy of phasing and imputation, especially around common CNVs. www.biorxiv.org/content/10.1...
Reposted by Mitchell R. Vollger
Check out our new preprint describing CiFi - a method that couples 3C and PacBio HiFi sequencing with low input requirements. We apply it to human GM12878 to better characterize chromatin across repetitive regions, as well as single insect samples (a mosquito and a Mediterranean fruit fly).
CiFi: Accurate long-read chromatin conformation capture with low-input requirements https://www.biorxiv.org/content/10.1101/2025.01.31.635566v1
February 5, 2025 at 11:49 PM
Check out our new preprint describing CiFi - a method that couples 3C and PacBio HiFi sequencing with low input requirements. We apply it to human GM12878 to better characterize chromatin across repetitive regions, as well as single insect samples (a mosquito and a Mediterranean fruit fly).
Reposted by Mitchell R. Vollger
This is the way
The "kitchen sink" of omics to solve the basis for an undiagnosed disease: long read genome , transcriptome, methytome, epigenome, all synchronized (a first)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition - Nature Genetics
Simultaneous profiling of the genome, methylome, epigenome and transcriptome using single-molecule chromatin fiber sequencing and multiplexed arrays isoform sequencing identifies the genetic and molec...
www.nature.com
January 29, 2025 at 2:54 PM
This is the way
Reposted by Mitchell R. Vollger
The "kitchen sink" of omics to solve the basis for an undiagnosed disease: long read genome , transcriptome, methytome, epigenome, all synchronized (a first)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition - Nature Genetics
Simultaneous profiling of the genome, methylome, epigenome and transcriptome using single-molecule chromatin fiber sequencing and multiplexed arrays isoform sequencing identifies the genetic and molec...
www.nature.com
January 29, 2025 at 2:45 PM
The "kitchen sink" of omics to solve the basis for an undiagnosed disease: long read genome , transcriptome, methytome, epigenome, all synchronized (a first)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mitchell R. Vollger
The biggest congrats to former Dennis lab grad student Daniela Soto being named an HHMI Hanna Gray fellow!!! Soooooooo freaking proud and beyond-the-moon happy for her to have received this super well-deserved honor 🤩 www.hhmi.org/news/hhmi-na...
HHMI Names the 2024 Hanna Gray Fellows | HHMI
The cohort includes early career scientists working in research areas ranging from treatment-resistant cancers to how animals evolved to live on land. The HHMI Hanna H. Gray Fellows Program provides e...
www.hhmi.org
January 9, 2025 at 3:04 AM
The biggest congrats to former Dennis lab grad student Daniela Soto being named an HHMI Hanna Gray fellow!!! Soooooooo freaking proud and beyond-the-moon happy for her to have received this super well-deserved honor 🤩 www.hhmi.org/news/hhmi-na...
Reposted by Mitchell R. Vollger
“StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data” is now on biorxiv! In this work, we explore the use of long-read sequencing (#PacBio #HiFi) for #pharmacogenomics #PGx. 1/N
Pre-print: doi.org/10.1101/2024...
Repo: github.com/PacificBiosc...
Pre-print: doi.org/10.1101/2024...
Repo: github.com/PacificBiosc...
GitHub - PacificBiosciences/pb-StarPhase: A phase-aware pharmacogenomic diplotyper for PacBio datasets
A phase-aware pharmacogenomic diplotyper for PacBio datasets - PacificBiosciences/pb-StarPhase
github.com
December 11, 2024 at 2:30 PM
“StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data” is now on biorxiv! In this work, we explore the use of long-read sequencing (#PacBio #HiFi) for #pharmacogenomics #PGx. 1/N
Pre-print: doi.org/10.1101/2024...
Repo: github.com/PacificBiosc...
Pre-print: doi.org/10.1101/2024...
Repo: github.com/PacificBiosc...
Reposted by Mitchell R. Vollger
Check out our recent preprint, co-led by two former PhD students in the lab Daniela Soto and José Uribe-Salazar, in which we identify and characterize human duplicated genes implicated in brain evolution. www.biorxiv.org/content/10.1...
Gene expansions contributing to human brain evolution
Genomic drivers of human-specific neurological traits remain largely undiscovered. Duplicated genes expanded uniquely in the human lineage likely contributed to brain evolution, including the increase...
www.biorxiv.org
September 27, 2024 at 4:05 PM
Check out our recent preprint, co-led by two former PhD students in the lab Daniela Soto and José Uribe-Salazar, in which we identify and characterize human duplicated genes implicated in brain evolution. www.biorxiv.org/content/10.1...