@mnprioleau.bsky.social
Group leader@ijmonod. Studying DNA replication and genomic instability
Reposted
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 8:34 AM
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
Reposted
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:41 PM
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
Reposted
🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination
Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium , elimination of transposable ele...
doi.org
October 21, 2025 at 2:46 PM
🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
Reposted
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
fr.scribd.com/document/934...
Offer PhD Position Team Lambert | PDF | Genetics | Life Sciences
3-year PhD offer in biology to mechanisms of complex rearrangements of the genome.
fr.scribd.com
October 19, 2025 at 7:32 PM
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
fr.scribd.com/document/934...
Reposted
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms
academic.oup.com
October 17, 2025 at 11:58 AM
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
Reposted
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted
The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social
www.cell.com/developmenta...
www.cell.com/developmenta...
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing,
which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication
stress. Drosophila wing ...
www.cell.com
October 7, 2025 at 6:43 AM
The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Reposted
#JobOffer
💼 Ingénieur d'étude H/F en biologie moléculaire
📆 1e décembre 2025
📍 Institut Jacques Monod / @mnprioleau.bsky.social
Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗 emploi.cnrs.fr/Offres/CDD/U...
💼 Ingénieur d'étude H/F en biologie moléculaire
📆 1e décembre 2025
📍 Institut Jacques Monod / @mnprioleau.bsky.social
Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗 emploi.cnrs.fr/Offres/CDD/U...
September 16, 2025 at 9:24 AM
#JobOffer
💼 Ingénieur d'étude H/F en biologie moléculaire
📆 1e décembre 2025
📍 Institut Jacques Monod / @mnprioleau.bsky.social
Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗 emploi.cnrs.fr/Offres/CDD/U...
💼 Ingénieur d'étude H/F en biologie moléculaire
📆 1e décembre 2025
📍 Institut Jacques Monod / @mnprioleau.bsky.social
Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗 emploi.cnrs.fr/Offres/CDD/U...
Reposted
Eliminating both #separase inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II #oocytes
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....
August 6, 2025 at 5:34 PM
Eliminating both #separase inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II #oocytes
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....
Reposted
Just a few more days left to apply!
We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
August 26, 2025 at 12:54 PM
Just a few more days left to apply!
Reposted
Our paper is now out in Molecular Cell!
Check the thread in this former post:
www.cell.com/molecular-ce...
Check the thread in this former post:
www.cell.com/molecular-ce...
July 17, 2025 at 5:41 PM
Our paper is now out in Molecular Cell!
Check the thread in this former post:
www.cell.com/molecular-ce...
Check the thread in this former post:
www.cell.com/molecular-ce...
Reposted
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
August 27, 2025 at 12:00 PM
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
Reposted
I believe that over the past ~ two decades, since the breakthrough papers on UHRF1, this is the first reported DNA methylation phenotype of its close paralog, UHRF2 (and not for lack of trying). Congrats to Ambre Bender and Michael Weber on this fantastic study! www.nature.com/articles/s41...
UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells - Nature Communications
DNA methylation in mouse primordial germ cells (PGCs) is restricted to transposable elements, but how this unique DNA methylome is established is poorly understood. Here, the authors identify UHRF2 as...
www.nature.com
August 9, 2025 at 6:26 PM
I believe that over the past ~ two decades, since the breakthrough papers on UHRF1, this is the first reported DNA methylation phenotype of its close paralog, UHRF2 (and not for lack of trying). Congrats to Ambre Bender and Michael Weber on this fantastic study! www.nature.com/articles/s41...
Reposted
Hi everyone!
The latest method from the Whitehouse lab: PCP
PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level:
Out soon, check the updated BioRxiv – little thread:
1/11
www.biorxiv.org/content/10.1...
The latest method from the Whitehouse lab: PCP
PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level:
Out soon, check the updated BioRxiv – little thread:
1/11
www.biorxiv.org/content/10.1...
May 30, 2025 at 7:55 PM
Hi everyone!
The latest method from the Whitehouse lab: PCP
PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level:
Out soon, check the updated BioRxiv – little thread:
1/11
www.biorxiv.org/content/10.1...
The latest method from the Whitehouse lab: PCP
PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level:
Out soon, check the updated BioRxiv – little thread:
1/11
www.biorxiv.org/content/10.1...
Reposted
I'm proud to announce the latest release of 🧬 #Oxbow 🏹, with new features to make NGS data analysis more powerful, efficient, and "composable".
Learn more at: oxbow.readthedocs.io
Learn more at: oxbow.readthedocs.io
July 7, 2025 at 9:22 PM
I'm proud to announce the latest release of 🧬 #Oxbow 🏹, with new features to make NGS data analysis more powerful, efficient, and "composable".
Learn more at: oxbow.readthedocs.io
Learn more at: oxbow.readthedocs.io
Reposted
Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf
July 12, 2025 at 11:32 AM
Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf
Reposted
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic
academic.oup.com
July 10, 2025 at 2:55 PM
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
Reposted
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...
June 19, 2025 at 8:37 AM
Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...
Reposted
Genome Biology conference in Birmingham UK in September. Check out our great invited speakers! Lots of slots for talks selected from abstracts too! Please repost 😀
The Birmingham Centre for Genome Biology invites you
to join us at our 10th year anniversary conference!
Website and Registration here: shorturl.at/rvJSr
Fantastic speakers, and a very cost-efficient meeting for ECRs and all. Talk slots are available. See you in Brum on 11-12th September 2025!
to join us at our 10th year anniversary conference!
Website and Registration here: shorturl.at/rvJSr
Fantastic speakers, and a very cost-efficient meeting for ECRs and all. Talk slots are available. See you in Brum on 11-12th September 2025!
June 25, 2025 at 3:41 PM
Genome Biology conference in Birmingham UK in September. Check out our great invited speakers! Lots of slots for talks selected from abstracts too! Please repost 😀
Reposted
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
Beetween
app.beetween.com
June 13, 2025 at 1:28 PM
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc.
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
app.beetween.com/WeaselWeb/p/...
Don't hesitate to apply or share the post !
Reposted
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
May 12, 2025 at 5:49 PM
Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)
Reposted
#JobOffer
💼 Ingénieur d’étude H/F en biologie moléculaire
📍 Equipe Prioleau
📅 1e septembre 2025
🔗 emploi.cnrs.fr/Offres/CDD/U...
Candidatez avant le 19 mai 2025
💼 Ingénieur d’étude H/F en biologie moléculaire
📍 Equipe Prioleau
📅 1e septembre 2025
🔗 emploi.cnrs.fr/Offres/CDD/U...
Candidatez avant le 19 mai 2025
April 28, 2025 at 9:33 AM
#JobOffer
💼 Ingénieur d’étude H/F en biologie moléculaire
📍 Equipe Prioleau
📅 1e septembre 2025
🔗 emploi.cnrs.fr/Offres/CDD/U...
Candidatez avant le 19 mai 2025
💼 Ingénieur d’étude H/F en biologie moléculaire
📍 Equipe Prioleau
📅 1e septembre 2025
🔗 emploi.cnrs.fr/Offres/CDD/U...
Candidatez avant le 19 mai 2025
Reposted
✍️ The @vdoye.bsky.social Lab contributed to the publication of a new article
📖 @naturecomms.bsky.social
📃 Nuclear pores safeguard the integrity of the nuclear envelope
🔗 www.nature.com/articles/s41...
📖 @naturecomms.bsky.social
📃 Nuclear pores safeguard the integrity of the nuclear envelope
🔗 www.nature.com/articles/s41...
April 11, 2025 at 12:49 PM
✍️ The @vdoye.bsky.social Lab contributed to the publication of a new article
📖 @naturecomms.bsky.social
📃 Nuclear pores safeguard the integrity of the nuclear envelope
🔗 www.nature.com/articles/s41...
📖 @naturecomms.bsky.social
📃 Nuclear pores safeguard the integrity of the nuclear envelope
🔗 www.nature.com/articles/s41...