Neuronal Signalling Lab
@mjc-lab.bsky.social
Focused on increasing throughput of optical methods to study signalling in disease. Located at Turku Bioscience, Turku, Finland.
Reposted by Neuronal Signalling Lab
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
January 26, 2026 at 8:50 PM
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
Reposted by Neuronal Signalling Lab
Here's binding curves, with and without a ~40 mT magnetic field.
We estimate a handheld magnet changes the binding affinity by ~3x.
This is the world's first (real) demonstration of "magnetogenetics" - controlling protein function with nontoxic, tissue-penetrating magnetic fields.
We estimate a handheld magnet changes the binding affinity by ~3x.
This is the world's first (real) demonstration of "magnetogenetics" - controlling protein function with nontoxic, tissue-penetrating magnetic fields.
January 13, 2026 at 4:57 AM
Here's binding curves, with and without a ~40 mT magnetic field.
We estimate a handheld magnet changes the binding affinity by ~3x.
This is the world's first (real) demonstration of "magnetogenetics" - controlling protein function with nontoxic, tissue-penetrating magnetic fields.
We estimate a handheld magnet changes the binding affinity by ~3x.
This is the world's first (real) demonstration of "magnetogenetics" - controlling protein function with nontoxic, tissue-penetrating magnetic fields.
Reposted by Neuronal Signalling Lab
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
January 13, 2026 at 4:57 AM
Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Its binding turns on and off with a magnet.
This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.
Reposted by Neuronal Signalling Lab
Researchers have engineered magnetically controlled fluorescent proteins that can be remotely dimmed and brightened in cells and living animals
go.nature.com/3NUSY12
go.nature.com/3NUSY12
‘Remote controlled’ proteins illuminate living cells
The discovery that some fluorescent proteins are sensitive to magnets could lead to the development of switchable drugs and biosensors.
go.nature.com
January 21, 2026 at 5:46 PM
Researchers have engineered magnetically controlled fluorescent proteins that can be remotely dimmed and brightened in cells and living animals
go.nature.com/3NUSY12
go.nature.com/3NUSY12
Reposted by Neuronal Signalling Lab
A new interesting opening at our Microscopy Core Facility. There is still time to apply!
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028
abo.rekrytointi.com
January 19, 2026 at 9:06 AM
A new interesting opening at our Microscopy Core Facility. There is still time to apply!
Our snouty v3 (AMS-AGY v3) objective arrived today! Looking forward to getting it installed on our single objective light sheet system very soon...
January 19, 2026 at 7:04 PM
Our snouty v3 (AMS-AGY v3) objective arrived today! Looking forward to getting it installed on our single objective light sheet system very soon...
Reposted by Neuronal Signalling Lab
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028
abo.rekrytointi.com
January 15, 2026 at 2:04 PM
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
Reposted by Neuronal Signalling Lab
I’m very happy that our paper is now published in Angewandte Chemie! 👏 A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells.
↪️ onlinelibrary.wiley.com/doi/full/10....
Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏
↪️ onlinelibrary.wiley.com/doi/full/10....
Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏
November 13, 2025 at 5:57 PM
I’m very happy that our paper is now published in Angewandte Chemie! 👏 A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells.
↪️ onlinelibrary.wiley.com/doi/full/10....
Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏
↪️ onlinelibrary.wiley.com/doi/full/10....
Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏
Reposted by Neuronal Signalling Lab
Excited to share the second chapter of my PhD work - Photoclickable HaloTag Ligands for Spatiotemporal Multiplexed Protein Labeling on Living Cells! 🥳 A big thank you to @clairedeo.bsky.social and all co-authors who contributed to this work.
➡️ www.biorxiv.org/content/10.1...
➡️ www.biorxiv.org/content/10.1...
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 5:53 PM
Excited to share the second chapter of my PhD work - Photoclickable HaloTag Ligands for Spatiotemporal Multiplexed Protein Labeling on Living Cells! 🥳 A big thank you to @clairedeo.bsky.social and all co-authors who contributed to this work.
➡️ www.biorxiv.org/content/10.1...
➡️ www.biorxiv.org/content/10.1...
Reposted by Neuronal Signalling Lab
(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning
Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...
www.science.org
October 17, 2025 at 11:06 AM
(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
Reposted by Neuronal Signalling Lab
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
#HappyFluorescenceFriday!
#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!
Learn more & sign up: buff.ly/esGIotD
#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!
Learn more & sign up: buff.ly/esGIotD
September 23, 2025 at 3:48 PM
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
Reposted by Neuronal Signalling Lab
I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao!
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
April 21, 2025 at 4:07 PM
I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao!
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?
Reposted by Neuronal Signalling Lab
Our manuscript on accelerating the acquisition rate in oblique plane microscopy (OPM) is online now:
opg.optica.org/boe/fulltext...
Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n
opg.optica.org/boe/fulltext...
Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n
April 2, 2025 at 6:21 PM
Our manuscript on accelerating the acquisition rate in oblique plane microscopy (OPM) is online now:
opg.optica.org/boe/fulltext...
Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n
opg.optica.org/boe/fulltext...
Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n
Reposted by Neuronal Signalling Lab
Teach your #microscope how to print: Low-cost & rapid-iteration #OpenSource #microfabrication for #biology:
-µm-scale precision across cm-sized area
-no cleanroom requirement
-SU8 replacement
Preprint: doi.org/10.1101/2025...
#DIYbio #lab #instuments #imaging #microfluidics #fabrication #3Dprinted
-µm-scale precision across cm-sized area
-no cleanroom requirement
-SU8 replacement
Preprint: doi.org/10.1101/2025...
#DIYbio #lab #instuments #imaging #microfluidics #fabrication #3Dprinted
March 18, 2025 at 11:37 AM
Teach your #microscope how to print: Low-cost & rapid-iteration #OpenSource #microfabrication for #biology:
-µm-scale precision across cm-sized area
-no cleanroom requirement
-SU8 replacement
Preprint: doi.org/10.1101/2025...
#DIYbio #lab #instuments #imaging #microfluidics #fabrication #3Dprinted
-µm-scale precision across cm-sized area
-no cleanroom requirement
-SU8 replacement
Preprint: doi.org/10.1101/2025...
#DIYbio #lab #instuments #imaging #microfluidics #fabrication #3Dprinted
New in biorxiv on magnetogenetic design -
"key reaction step involved e- transfer ...to form a triplet spin-correlated radical pair. The magnetic field then controlled the branching ratio between singlet recombination vs. triplet separation."
www.biorxiv.org/content/10.1...
"key reaction step involved e- transfer ...to form a triplet spin-correlated radical pair. The magnetic field then controlled the branching ratio between singlet recombination vs. triplet separation."
www.biorxiv.org/content/10.1...
Mechanism of giant magnetic field effect in fluorescence of mScarlet3, a red fluorescent protein
Several fluorescent proteins, when expressed in E. coli, are sensitive to weak magnetic fields1. We found that mScarlet3 fluorescence in E. coli reversibly decreased by 21% in the presence of a 60 mT ...
www.biorxiv.org
March 2, 2025 at 10:48 PM
New in biorxiv on magnetogenetic design -
"key reaction step involved e- transfer ...to form a triplet spin-correlated radical pair. The magnetic field then controlled the branching ratio between singlet recombination vs. triplet separation."
www.biorxiv.org/content/10.1...
"key reaction step involved e- transfer ...to form a triplet spin-correlated radical pair. The magnetic field then controlled the branching ratio between singlet recombination vs. triplet separation."
www.biorxiv.org/content/10.1...
Reposted by Neuronal Signalling Lab
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
February 12, 2025 at 1:59 AM
I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.
Make your own:
github.com/amsikking/SO...
Or buy it from @jsdaniel02.bsky.social at ASI!
Reposted by Neuronal Signalling Lab
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
February 27, 2025 at 8:13 PM
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Reposted by Neuronal Signalling Lab
I am excited to announce that the Journal of Cell Science will have a special issue on imaging cell architecture and dynamics, guest-edited by myself and Lucy Collinson. Consider this issue to publish your work.
Find out more: journals.biologists.com/jcs/pages/im...
Find out more: journals.biologists.com/jcs/pages/im...
October 9, 2023 at 4:07 PM
I am excited to announce that the Journal of Cell Science will have a special issue on imaging cell architecture and dynamics, guest-edited by myself and Lucy Collinson. Consider this issue to publish your work.
Find out more: journals.biologists.com/jcs/pages/im...
Find out more: journals.biologists.com/jcs/pages/im...
Reposted by Neuronal Signalling Lab
New program out for IDPseminars!
New attendees sign up here: idpseminars.com
We have relied heavily on Twitter for our PR until now, so its slow but painful death spiral leaves us in a bit of a pickle. Please help us rebuild our following over here by re-tweeting.
New attendees sign up here: idpseminars.com
We have relied heavily on Twitter for our PR until now, so its slow but painful death spiral leaves us in a bit of a pickle. Please help us rebuild our following over here by re-tweeting.
October 6, 2023 at 1:00 PM
New program out for IDPseminars!
New attendees sign up here: idpseminars.com
We have relied heavily on Twitter for our PR until now, so its slow but painful death spiral leaves us in a bit of a pickle. Please help us rebuild our following over here by re-tweeting.
New attendees sign up here: idpseminars.com
We have relied heavily on Twitter for our PR until now, so its slow but painful death spiral leaves us in a bit of a pickle. Please help us rebuild our following over here by re-tweeting.
Reposted by Neuronal Signalling Lab
Biologists ask me all the time:
How can we gain computational skills?
Here are some thoughts! Quotes from Shantanu Singh, Virginie Uhlmann, Fernanda Garcia Fossa, and @bethcimini.bsky.social
www.nature.com/articles/d41...
How can we gain computational skills?
Here are some thoughts! Quotes from Shantanu Singh, Virginie Uhlmann, Fernanda Garcia Fossa, and @bethcimini.bsky.social
www.nature.com/articles/d41...
www.nature.com
October 4, 2023 at 8:05 PM
Biologists ask me all the time:
How can we gain computational skills?
Here are some thoughts! Quotes from Shantanu Singh, Virginie Uhlmann, Fernanda Garcia Fossa, and @bethcimini.bsky.social
www.nature.com/articles/d41...
How can we gain computational skills?
Here are some thoughts! Quotes from Shantanu Singh, Virginie Uhlmann, Fernanda Garcia Fossa, and @bethcimini.bsky.social
www.nature.com/articles/d41...