Milo B. Fasken, Ph.D.
@milofasken.bsky.social
Senior Scientist, Department of Biology, Emory University, Atlanta, GA.
Molecular Biologist. RNA Scientist. Yeast Geneticist 🧬. British🇬🇧. Runner 🏃🏻…. Opinions are my own.
Interests: RNA Decay, RNA Processing, RNA & Disease.
Molecular Biologist. RNA Scientist. Yeast Geneticist 🧬. British🇬🇧. Runner 🏃🏻…. Opinions are my own.
Interests: RNA Decay, RNA Processing, RNA & Disease.
Pinned
Glad to have joined Bluesky yesterday! Great to have followed so many old and new friends/colleagues. Looking forward to all the great RNA biology and fun science chats!
#RNA #RNASky
P.S. Are there any Starter Packs for model organisms, especially, #BuddingYeast #Scerevisiae?
#RNA #RNASky
P.S. Are there any Starter Packs for model organisms, especially, #BuddingYeast #Scerevisiae?
Nice work! #Nab3 #Nrd1 #Sen1 #NNS
A transcription termination mechanism for maintaining homogeneous protein expression url: academic.oup.com/nar/article/...
A transcription termination mechanism for maintaining homogeneous protein expression url: academic.oup.com/nar/article/...
A transcription termination mechanism for maintaining homogeneous protein expression
Abstract. Premature transcription termination is a critical mechanism for repressing harmful, unproductive transcription. In Saccharomyces cerevisiae, prem
academic.oup.com
November 20, 2025 at 6:18 PM
Nice work! #Nab3 #Nrd1 #Sen1 #NNS
A transcription termination mechanism for maintaining homogeneous protein expression url: academic.oup.com/nar/article/...
A transcription termination mechanism for maintaining homogeneous protein expression url: academic.oup.com/nar/article/...
www.nature.com
October 31, 2025 at 10:59 AM
Reposted by Milo B. Fasken, Ph.D.
Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...
Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology
As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.
www.nature.com
October 11, 2025 at 8:03 AM
Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...
Time-resolved fluorescent proteins expand #fluorescent #microscopy in temporal and spectral domains: Cell www.cell.com/cell/fulltex...
Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
(Cell 188, ◼◼◼–◼◼◼.e1–e14; November 26, 2025)
www.cell.com
October 3, 2025 at 1:00 PM
Time-resolved fluorescent proteins expand #fluorescent #microscopy in temporal and spectral domains: Cell www.cell.com/cell/fulltex...
Nice review on #PCH #Disease
Pontocerebellar hypoplasia: a review from 1912 to 2022 url: academic.oup.com/braincomms/a...
Pontocerebellar hypoplasia: a review from 1912 to 2022 url: academic.oup.com/braincomms/a...
Pontocerebellar hypoplasia: a review from 1912 to 2022
Kukulka et al. report that pontocerebellar hypoplasia is most often linked to mutations in TSEN54, RARS2, EXOSC3 and AMPD2, with Types 1, 2, and 6 being mo
academic.oup.com
September 13, 2025 at 11:16 PM
Nice review on #PCH #Disease
Pontocerebellar hypoplasia: a review from 1912 to 2022 url: academic.oup.com/braincomms/a...
Pontocerebellar hypoplasia: a review from 1912 to 2022 url: academic.oup.com/braincomms/a...
Beautiful work! RRE binds CRM1. Wow! 😊
#HIV1 #Rev #RRE #CRM1 #Exportin1 #Ran
www.cell.com/molecular-ce...
#HIV1 #Rev #RRE #CRM1 #Exportin1 #Ran
www.cell.com/molecular-ce...
The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition
The HIV nuclear export complex shows that CRM1 recognizes diverse cargos through distinct
sites, utilizing multipartite recognition via the NES and additional protein and RNA
contacts. A unique CRM1 d...
www.cell.com
August 22, 2025 at 1:15 PM
Beautiful work! RRE binds CRM1. Wow! 😊
#HIV1 #Rev #RRE #CRM1 #Exportin1 #Ran
www.cell.com/molecular-ce...
#HIV1 #Rev #RRE #CRM1 #Exportin1 #Ran
www.cell.com/molecular-ce...
Nice #review!
#RNA #mRNA #mRNAProcessing
From transcription to export: mRNA’s winding path to the cytoplasm
Murray Stewart
www.cell.com/trends/bioch...
#RNA #mRNA #mRNAProcessing
From transcription to export: mRNA’s winding path to the cytoplasm
Murray Stewart
www.cell.com/trends/bioch...
From transcription to export: mRNA’s winding path to the cytoplasm
In eukaryotes, the separation of transcription from translation enables extensive
mRNA processing (capping, splicing, and polyadenylation) before translation. This
review focuses on recent work that p...
www.cell.com
August 16, 2025 at 3:33 PM
Nice #review!
#RNA #mRNA #mRNAProcessing
From transcription to export: mRNA’s winding path to the cytoplasm
Murray Stewart
www.cell.com/trends/bioch...
#RNA #mRNA #mRNAProcessing
From transcription to export: mRNA’s winding path to the cytoplasm
Murray Stewart
www.cell.com/trends/bioch...
#Dis3L2 #RNA #RNADecay
Structural and mechanistic insights into Dis3L2 mediated degradation of structured RNA
Rute G. Matos, Ankur Garg, Susana M. Costa, Patricia Pereira, Cecilia M. Arraiano, Leemor Joshua-Tor, Sandra C. Viegas
www.biorxiv.org/content/10.1...
Structural and mechanistic insights into Dis3L2 mediated degradation of structured RNA
Rute G. Matos, Ankur Garg, Susana M. Costa, Patricia Pereira, Cecilia M. Arraiano, Leemor Joshua-Tor, Sandra C. Viegas
www.biorxiv.org/content/10.1...
www.biorxiv.org
August 5, 2025 at 3:17 PM
#Dis3L2 #RNA #RNADecay
Structural and mechanistic insights into Dis3L2 mediated degradation of structured RNA
Rute G. Matos, Ankur Garg, Susana M. Costa, Patricia Pereira, Cecilia M. Arraiano, Leemor Joshua-Tor, Sandra C. Viegas
www.biorxiv.org/content/10.1...
Structural and mechanistic insights into Dis3L2 mediated degradation of structured RNA
Rute G. Matos, Ankur Garg, Susana M. Costa, Patricia Pereira, Cecilia M. Arraiano, Leemor Joshua-Tor, Sandra C. Viegas
www.biorxiv.org/content/10.1...
Reposted by Milo B. Fasken, Ph.D.
Human CCR4 deadenylase homolog Angel1 along with endonuclease N4BP2 and the SKI-exosome complex promotes degradation of aberrant mRNAs that lack stop codons causing ribosome stalling at the poly(A)-tail bit.ly/4lsYWC6
July 23, 2025 at 4:04 PM
Human CCR4 deadenylase homolog Angel1 along with endonuclease N4BP2 and the SKI-exosome complex promotes degradation of aberrant mRNAs that lack stop codons causing ribosome stalling at the poly(A)-tail bit.ly/4lsYWC6
Reposted by Milo B. Fasken, Ph.D.
Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications
Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...
www.nature.com
July 13, 2025 at 3:59 AM
Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
Reposted by Milo B. Fasken, Ph.D.
