Sebastian Shaw
@millseba.bsky.social
Dad. Scientist. Interested in how Cryptosoridium tricks its host cells!
Pinned
Sebastian Shaw
@millseba.bsky.social
· Sep 18
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
www.sciencedirect.com
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Reposted by Sebastian Shaw
New paper out !
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Stage-specific regulation of the Plasmodium falciparum proteasome activity reveals adaptive rewiring in artemisinin resistance
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum to maintain protein homeostasis, adapt to proteotoxic stress, and regulate parasite growth and stage transitions. The prote...
www.biorxiv.org
November 26, 2025 at 11:21 PM
New paper out !
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Reposted by Sebastian Shaw
Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research! @oupprimary.bsky.social @narjournal.bsky.social Read more here.
tinyurl.com/794brb6h
tinyurl.com/794brb6h
Validate User
tinyurl.com
November 26, 2025 at 4:16 PM
Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research! @oupprimary.bsky.social @narjournal.bsky.social Read more here.
tinyurl.com/794brb6h
tinyurl.com/794brb6h
Exciting news!!
I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, University of Zurich as an Assistant Professor in summer 2026.
A dream come true! 🥺
October 31, 2025 at 2:39 PM
Exciting news!!
I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, University of Zurich as an Assistant Professor in summer 2026.
A dream come true! 🥺
Reposted by Sebastian Shaw
✨ Searching for extraterrestrial life or combating speech disorders: The SNSF is awarding #SNSFStartingGrants to 41 outstanding researchers. They will receive a maximum of CHF 1 million to lead a project with their own #research team at a Swiss university. 🚀
ℹ️ sohub.io/aq26
ℹ️ sohub.io/aq26
October 31, 2025 at 9:30 AM
✨ Searching for extraterrestrial life or combating speech disorders: The SNSF is awarding #SNSFStartingGrants to 41 outstanding researchers. They will receive a maximum of CHF 1 million to lead a project with their own #research team at a Swiss university. 🚀
ℹ️ sohub.io/aq26
ℹ️ sohub.io/aq26
Reposted by Sebastian Shaw
Save the date, next Cryptosporidium meeting in Edinburgh May 24-26, 2026. Register for email updates via the QR code below.
October 13, 2025 at 11:42 AM
Save the date, next Cryptosporidium meeting in Edinburgh May 24-26, 2026. Register for email updates via the QR code below.
As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll | Science | AAAS www.science.org/content/arti...
As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll
“I began to question whether I truly belonged,” this postdoc writes
www.science.org
October 21, 2025 at 4:36 AM
As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll | Science | AAAS www.science.org/content/arti...
Reposted by Sebastian Shaw
The parasitesrule site has an archive of abstract books from the Molecular Parasitology Meeting (MPM) & the Kinetoplastid Molecular Cell Biology Meeting (KMCB). The book from the first MPM (1990) is also there!
🔗 parasitesrule.com/archive
🔗 parasitesrule.com/archive
October 15, 2025 at 1:41 PM
The parasitesrule site has an archive of abstract books from the Molecular Parasitology Meeting (MPM) & the Kinetoplastid Molecular Cell Biology Meeting (KMCB). The book from the first MPM (1990) is also there!
🔗 parasitesrule.com/archive
🔗 parasitesrule.com/archive
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance
The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...
www.biorxiv.org
October 8, 2025 at 11:25 AM
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
www.sciencedirect.com
September 18, 2025 at 10:13 PM
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
How many red flags more will it take?
September 18, 2025 at 2:44 AM
How many red flags more will it take?
Happy #SwissNationalDay 🇨🇭
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
August 1, 2025 at 10:40 AM
Happy #SwissNationalDay 🇨🇭
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
No ERC Starting Grant this time 😔
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
July 16, 2025 at 8:21 AM
No ERC Starting Grant this time 😔
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
“Coachella of molecular parasitologists” 😜
Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi
🔗https://www.parasitesrule.com/mpm-xxxvi
June 6, 2025 at 12:32 AM
“Coachella of molecular parasitologists” 😜
Just had my ERC Starting grant interview. Now the wait is on! 🤞🏻🤞🏻🤞🏻
June 4, 2025 at 7:32 PM
Just had my ERC Starting grant interview. Now the wait is on! 🤞🏻🤞🏻🤞🏻
Reposted by Sebastian Shaw
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
May 30, 2025 at 9:52 PM
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
Reposted by Sebastian Shaw
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1
May 22, 2025 at 3:32 AM
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1
🚨 Preprint Alert 🚨
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. An array of parasites with similar genomes produce...
www.biorxiv.org
May 22, 2025 at 3:52 PM
🚨 Preprint Alert 🚨
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
Reposted by Sebastian Shaw
🚨Out now!
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology
Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...
www.nature.com
May 20, 2025 at 2:50 PM
🚨Out now!
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
Reposted by Sebastian Shaw
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance
Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...
rdcu.be
May 16, 2025 at 2:08 PM
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
Reposted by Sebastian Shaw
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...
elxw.fa.em3.oraclecloud.com
May 16, 2025 at 10:48 AM
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Two toddlers in a sandbox, flinging toys at each other because one wouldn’t share a shovel — each tantrum louder than the last, while the whole playground suffers from the mess.
April 11, 2025 at 10:51 AM
Two toddlers in a sandbox, flinging toys at each other because one wouldn’t share a shovel — each tantrum louder than the last, while the whole playground suffers from the mess.