Michal Gdula
@michal-gdula.bsky.social
PI @uam-ibmib.bsky.social, developmental epigenetics, 3D nuclear architecture, prev postdoc @bostonu.bsky.social & @ox.ac.uk 🇵🇱 🇪🇺 #StandWithUkraine 🇺🇦 https://ibmib.web.amu.edu.pl/groups/developmental-epigenetics-research-group/
Reposted by Michal Gdula
Join us this Friday morning for the @uam-ibmib.bsky.social seminar: Agata Starosta @agatastarosta.bsky.social from the Institute of Biochemistry and Biophysics PAS will give a talk on on translational control in #BacillusSubtilis during sporulation! #translation
November 13, 2025 at 4:10 PM
Join us this Friday morning for the @uam-ibmib.bsky.social seminar: Agata Starosta @agatastarosta.bsky.social from the Institute of Biochemistry and Biophysics PAS will give a talk on on translational control in #BacillusSubtilis during sporulation! #translation
Reposted by Michal Gdula
Conrad Hal Waddington was born OTD in 1905.
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
November 8, 2025 at 4:03 PM
Reposted by Michal Gdula
Join us on Friday for @uam-ibmib.bsky.social IBMiB seminar of Halina Petrykowska from our Department of Gene Expression to learn about male-specific #miRNAs whihc regulate sperm development and function in Marchantia polymorpha!
November 6, 2025 at 6:01 PM
Join us on Friday for @uam-ibmib.bsky.social IBMiB seminar of Halina Petrykowska from our Department of Gene Expression to learn about male-specific #miRNAs whihc regulate sperm development and function in Marchantia polymorpha!
Reposted by Michal Gdula
Reposted by Michal Gdula
I've updated my Bioinformatics Bootcamp: Zebrafish Special Edition blog post on @the-node.bsky.social! Please do share with trainees or anyone new to the community. I hope it adds some breadth to the many resources available to #zebrafish researchers. 🔗 thenode.biologists.com/bioinformati...
Bioinformatics Bootcamp - Zebrafish Special Edition - the Node
A deep-dive into the many cool (and free) resources available to zebrafish researchers! Disclaimer: This is not a comprehensive list but a list of useful
thenode.biologists.com
November 2, 2025 at 3:57 PM
I've updated my Bioinformatics Bootcamp: Zebrafish Special Edition blog post on @the-node.bsky.social! Please do share with trainees or anyone new to the community. I hope it adds some breadth to the many resources available to #zebrafish researchers. 🔗 thenode.biologists.com/bioinformati...
Reposted by Michal Gdula
Don't miss this Friday's @uam-ibmib.bsky.social
seminar! Agata Stepień from @stoplab.bsky.social & AMU Centre of Advanced Technologies presents her latest research on pre-mRNA 3' end processing and #transcriptionTermination. #RNAbiology
seminar! Agata Stepień from @stoplab.bsky.social & AMU Centre of Advanced Technologies presents her latest research on pre-mRNA 3' end processing and #transcriptionTermination. #RNAbiology
October 30, 2025 at 2:44 PM
Don't miss this Friday's @uam-ibmib.bsky.social
seminar! Agata Stepień from @stoplab.bsky.social & AMU Centre of Advanced Technologies presents her latest research on pre-mRNA 3' end processing and #transcriptionTermination. #RNAbiology
seminar! Agata Stepień from @stoplab.bsky.social & AMU Centre of Advanced Technologies presents her latest research on pre-mRNA 3' end processing and #transcriptionTermination. #RNAbiology
Reposted by Michal Gdula
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 9:55 AM
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
Reposted by Michal Gdula
⏰ Last week to apply!
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
🚀 We’re hiring a Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
October 25, 2025 at 5:48 AM
⏰ Last week to apply!
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿
👉 Deadline: Nov 1, 2025
Reposted by Michal Gdula
Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 17, 2025 at 5:50 AM
Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬
Reposted by Michal Gdula
EpiSci - 🧬 - 🧪 - 3D Chromatin organization persists during Mitosis.
👇🏽👇🏽👇🏽
Dynamics of microcompartment formation at the mitosis-to-G1 transition
www.nature.com/articles/s41...
👇🏽👇🏽👇🏽
Dynamics of microcompartment formation at the mitosis-to-G1 transition
www.nature.com/articles/s41...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
October 18, 2025 at 4:48 AM
EpiSci - 🧬 - 🧪 - 3D Chromatin organization persists during Mitosis.
👇🏽👇🏽👇🏽
Dynamics of microcompartment formation at the mitosis-to-G1 transition
www.nature.com/articles/s41...
👇🏽👇🏽👇🏽
Dynamics of microcompartment formation at the mitosis-to-G1 transition
www.nature.com/articles/s41...
Reposted by Michal Gdula
Join us on Monday for @UAM_IBMiB seminar of Jacek Nowak from the Institute of Biochemistry and Biophysics to learn Elongation factors in synthesis of developmentally controlled non-coding RNA in Paramecium ! #ncRNA
October 16, 2025 at 1:34 PM
Join us on Monday for @UAM_IBMiB seminar of Jacek Nowak from the Institute of Biochemistry and Biophysics to learn Elongation factors in synthesis of developmentally controlled non-coding RNA in Paramecium ! #ncRNA
Reposted by Michal Gdula
Amazing to have our work finally out!!! 😍🤩😍
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 6:38 PM
Amazing to have our work finally out!!! 😍🤩😍
Reposted by Michal Gdula
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Michal Gdula
🚀 We’re hiring a Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
September 27, 2025 at 5:03 AM
🚀 We’re hiring a Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Reposted by Michal Gdula
Disney/ABC have a responsibility to refuse to participate in corruption.
Kimmel must be reinstated. If Disney/ABC agree to this extortion then perhaps creatives + workers should consider collective action to push back. Same w/buying park + cruise tickets if they bow.
People have power. Ask Target
Kimmel must be reinstated. If Disney/ABC agree to this extortion then perhaps creatives + workers should consider collective action to push back. Same w/buying park + cruise tickets if they bow.
People have power. Ask Target
September 20, 2025 at 1:13 AM
Disney/ABC have a responsibility to refuse to participate in corruption.
Kimmel must be reinstated. If Disney/ABC agree to this extortion then perhaps creatives + workers should consider collective action to push back. Same w/buying park + cruise tickets if they bow.
People have power. Ask Target
Kimmel must be reinstated. If Disney/ABC agree to this extortion then perhaps creatives + workers should consider collective action to push back. Same w/buying park + cruise tickets if they bow.
People have power. Ask Target
Reposted by Michal Gdula
Nature Review: Cis-regulatory elements at cellular resolution
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Cis-regulatory elements at cellular resolution
Nature Reviews Genetics - In this Comment, the authors outline some key next steps to advance our understanding of cis-regulatory elements at single-cell resolution, which includes harmonizing...
www.nature.com
September 19, 2025 at 2:15 PM
Nature Review: Cis-regulatory elements at cellular resolution
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by Michal Gdula
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
September 18, 2025 at 4:14 PM
Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
The E2G Portal! e2g.stanford.edu
This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.
Uses cases 👇
1/
Reposted by Michal Gdula
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 7:50 AM
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Michal Gdula
I'm voting for free speech with my wallet, and cancelling my Disney+ subscription.
The union representing the musicians from Jimmy Kimmel’s band releases a statement calling the FCC’s pressure on Disney “state censorship.”
September 18, 2025 at 10:48 AM
I'm voting for free speech with my wallet, and cancelling my Disney+ subscription.
Reposted by Michal Gdula
New preprint from our lab!
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
September 19, 2025 at 3:03 AM
New preprint from our lab!
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?
Find out here: www.biorxiv.org/content/10.1...
👇
1/
Reposted by Michal Gdula
After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.
Let’s be clear about what happened to Jimmy Kimmel
Trump’s most brazen attack on free speech yet.
www.yahoo.com
September 18, 2025 at 2:10 PM
After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.
Great #EMBOdnatopology meeting in Szklarska Poręba: exciting science, inspiring discussions, and pleased to share our #DNAreplication work! Thanks to Dagmara Jakimowicz, Marcin Szafran & organizers! @embo.org
September 18, 2025 at 5:50 AM
Great #EMBOdnatopology meeting in Szklarska Poręba: exciting science, inspiring discussions, and pleased to share our #DNAreplication work! Thanks to Dagmara Jakimowicz, Marcin Szafran & organizers! @embo.org
Many great talks at the #E2BRN & #ESDR2025 meeting! Glad to share recent work form my lab on keratinocyte epigenetics and catch up with old friends! Big thanks to Danuta Gutowska-Owsiak
& Ryan O'Shaughnessy for organising #E2BRN! #epigenetics @esdrorg.bsky.social
& Ryan O'Shaughnessy for organising #E2BRN! #epigenetics @esdrorg.bsky.social
September 12, 2025 at 11:08 AM
Many great talks at the #E2BRN & #ESDR2025 meeting! Glad to share recent work form my lab on keratinocyte epigenetics and catch up with old friends! Big thanks to Danuta Gutowska-Owsiak
& Ryan O'Shaughnessy for organising #E2BRN! #epigenetics @esdrorg.bsky.social
& Ryan O'Shaughnessy for organising #E2BRN! #epigenetics @esdrorg.bsky.social
It's been great pleasure to host Takeshi Matsui in Poznan @uam-ibmib.bsky.social
- amazing talk, meeting with PhD students & postdocs, inspiring science discussions! Many thanks to #ID_UB for funding! #epigenetics #epidermalBarier #corneoptosis #E2BRN
- amazing talk, meeting with PhD students & postdocs, inspiring science discussions! Many thanks to #ID_UB for funding! #epigenetics #epidermalBarier #corneoptosis #E2BRN
September 12, 2025 at 8:05 AM
It's been great pleasure to host Takeshi Matsui in Poznan @uam-ibmib.bsky.social
- amazing talk, meeting with PhD students & postdocs, inspiring science discussions! Many thanks to #ID_UB for funding! #epigenetics #epidermalBarier #corneoptosis #E2BRN
- amazing talk, meeting with PhD students & postdocs, inspiring science discussions! Many thanks to #ID_UB for funding! #epigenetics #epidermalBarier #corneoptosis #E2BRN
Reposted by Michal Gdula
Join us on Monday for @UAM_IBMiB
seminar of Takeshi Matsui from the Tokyo University of Technology to learn about keratinocyte-specific cell-death in formation of epidermal barrier! PhD students/postdocs are welcome for the cereer advice meeting! #cellDeath #corneoptosis #ID_UB
seminar of Takeshi Matsui from the Tokyo University of Technology to learn about keratinocyte-specific cell-death in formation of epidermal barrier! PhD students/postdocs are welcome for the cereer advice meeting! #cellDeath #corneoptosis #ID_UB
September 4, 2025 at 10:33 AM
Join us on Monday for @UAM_IBMiB
seminar of Takeshi Matsui from the Tokyo University of Technology to learn about keratinocyte-specific cell-death in formation of epidermal barrier! PhD students/postdocs are welcome for the cereer advice meeting! #cellDeath #corneoptosis #ID_UB
seminar of Takeshi Matsui from the Tokyo University of Technology to learn about keratinocyte-specific cell-death in formation of epidermal barrier! PhD students/postdocs are welcome for the cereer advice meeting! #cellDeath #corneoptosis #ID_UB