Mathieu Bourdenx
@mbourdenx.bsky.social
Neuroscientist at @UKDRI at UCL working on Ageing and Dementia. 🧠
Dad x2
Serial procrastinator
Dad x2
Serial procrastinator
Reposted by Mathieu Bourdenx
Making "AI Scientists" has become a hot topic lately. The first reference I could find was from 2008. The term has been used for 20 years! Like "Adam," an AI Scientist robot for studying yeast was published in 2009. I wrote a short post about the term and what it means now.
diffuse.one/p/w1-001
diffuse.one/p/w1-001
October 29, 2025 at 6:26 PM
Making "AI Scientists" has become a hot topic lately. The first reference I could find was from 2008. The term has been used for 20 years! Like "Adam," an AI Scientist robot for studying yeast was published in 2009. I wrote a short post about the term and what it means now.
diffuse.one/p/w1-001
diffuse.one/p/w1-001
Reposted by Mathieu Bourdenx
Meet our new Future Leader Fellows!👏
Introducing @mbourdenx.bsky.social, Dr Sophie Morse & Dr Wioleta Zelek who have been awarded prestigious Future Leader Fellowships from @ukri.org ⬇️
Read more about their work👉 buff.ly/JOH2d9N
Introducing @mbourdenx.bsky.social, Dr Sophie Morse & Dr Wioleta Zelek who have been awarded prestigious Future Leader Fellowships from @ukri.org ⬇️
Read more about their work👉 buff.ly/JOH2d9N
September 26, 2025 at 4:18 PM
Meet our new Future Leader Fellows!👏
Introducing @mbourdenx.bsky.social, Dr Sophie Morse & Dr Wioleta Zelek who have been awarded prestigious Future Leader Fellowships from @ukri.org ⬇️
Read more about their work👉 buff.ly/JOH2d9N
Introducing @mbourdenx.bsky.social, Dr Sophie Morse & Dr Wioleta Zelek who have been awarded prestigious Future Leader Fellowships from @ukri.org ⬇️
Read more about their work👉 buff.ly/JOH2d9N
Reposted by Mathieu Bourdenx
🤖 Could an AI scientist help unlock the secrets of dementia?
Dr @mbourdenx.bsky.social (@ukdri.ac.uk at UCL), is working with @futurehousesf.bsky.social to explore how AI is transforming research.
buff.ly/O8RjZIX
#UCLDementia #WorldAlzheimersMonth
Dr @mbourdenx.bsky.social (@ukdri.ac.uk at UCL), is working with @futurehousesf.bsky.social to explore how AI is transforming research.
buff.ly/O8RjZIX
#UCLDementia #WorldAlzheimersMonth
September 25, 2025 at 10:08 AM
🤖 Could an AI scientist help unlock the secrets of dementia?
Dr @mbourdenx.bsky.social (@ukdri.ac.uk at UCL), is working with @futurehousesf.bsky.social to explore how AI is transforming research.
buff.ly/O8RjZIX
#UCLDementia #WorldAlzheimersMonth
Dr @mbourdenx.bsky.social (@ukdri.ac.uk at UCL), is working with @futurehousesf.bsky.social to explore how AI is transforming research.
buff.ly/O8RjZIX
#UCLDementia #WorldAlzheimersMonth
Reposted by Mathieu Bourdenx
Huge congratulations to Dr @angelikaza.bsky.social and Dr @mbourdenx.bsky.social who have both been awarded @ukri.org Future Leaders Fellowships! 🙌 @uclqsion.bsky.social @ukdri.ac.uk
Find out about their exciting projects: www.ucl.ac.uk/brain-scienc...
Find out about their exciting projects: www.ucl.ac.uk/brain-scienc...
September 16, 2025 at 2:43 PM
Huge congratulations to Dr @angelikaza.bsky.social and Dr @mbourdenx.bsky.social who have both been awarded @ukri.org Future Leaders Fellowships! 🙌 @uclqsion.bsky.social @ukdri.ac.uk
Find out about their exciting projects: www.ucl.ac.uk/brain-scienc...
Find out about their exciting projects: www.ucl.ac.uk/brain-scienc...
Reposted by Mathieu Bourdenx
“Ultimately, I see AI leading to an acceleration in discovery in dementia research that could be transformative for patients" says Dr @mbourdenx.bsky.social @ukdri.ac.uk, who is working with an "AI scientist", a system that can analyse data and suggest new research directions not yet explored
September 22, 2025 at 4:10 PM
“Ultimately, I see AI leading to an acceleration in discovery in dementia research that could be transformative for patients" says Dr @mbourdenx.bsky.social @ukdri.ac.uk, who is working with an "AI scientist", a system that can analyse data and suggest new research directions not yet explored
Reposted by Mathieu Bourdenx
I’m very happy 🥳 to share our new collaborative work, out today in Science Advances! Many thanks to all the co-authors!
Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...
Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...
Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates
Distinct α-synuclein assemblies trigger distinct neurotoxic cellular pathways.
www.science.org
June 18, 2025 at 6:36 PM
I’m very happy 🥳 to share our new collaborative work, out today in Science Advances! Many thanks to all the co-authors!
Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...
Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...
Reposted by Mathieu Bourdenx
"The biggest mystery is not why arXiv succeeded. Rather, it’s how it wasn’t killed by vested interests intent on protecting traditional academic publishing."
www.wired.com/story/inside...
www.wired.com/story/inside...
Inside arXiv—the Most Transformative Platform in All of Science
Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.
www.wired.com
March 28, 2025 at 10:56 AM
"The biggest mystery is not why arXiv succeeded. Rather, it’s how it wasn’t killed by vested interests intent on protecting traditional academic publishing."
www.wired.com/story/inside...
www.wired.com/story/inside...
Reposted by Mathieu Bourdenx
Reposted by Mathieu Bourdenx
Sur les retraites, Bayrou a menti.
Le "déficit caché" des retraites n’a jamais existé.
Pour justifier son refus d'abroger la réforme des retraites, il avait inventé un déficit de 55 milliards en 2030.
La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.
Le "déficit caché" des retraites n’a jamais existé.
Pour justifier son refus d'abroger la réforme des retraites, il avait inventé un déficit de 55 milliards en 2030.
La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.
February 20, 2025 at 12:27 PM
Sur les retraites, Bayrou a menti.
Le "déficit caché" des retraites n’a jamais existé.
Pour justifier son refus d'abroger la réforme des retraites, il avait inventé un déficit de 55 milliards en 2030.
La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.
Le "déficit caché" des retraites n’a jamais existé.
Pour justifier son refus d'abroger la réforme des retraites, il avait inventé un déficit de 55 milliards en 2030.
La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.
🚨Cool Job Alert 🚨consider joining this amazing and rocknroll lab
📢 Our lab is looking for a bioinformatics postdoc. We have lots of exciting projects to work on, including single cell (epi-)genomics, microglia xenotransplantations and nanopore long reads splicing analysis. Look out for the official advert next week and get in touch in the meantime 🧬🧠
February 12, 2025 at 10:22 PM
🚨Cool Job Alert 🚨consider joining this amazing and rocknroll lab
Reposted by Mathieu Bourdenx
Tesla paid $0 in federal income tax last year.
2022: $0
2021: $0
2020: $0
2019: $0
2018: $0
Tesla reported $6.7 billion in profit in those years.
2022: $0
2021: $0
2020: $0
2019: $0
2018: $0
Tesla reported $6.7 billion in profit in those years.
February 8, 2025 at 10:56 PM
Tesla paid $0 in federal income tax last year.
2022: $0
2021: $0
2020: $0
2019: $0
2018: $0
Tesla reported $6.7 billion in profit in those years.
2022: $0
2021: $0
2020: $0
2019: $0
2018: $0
Tesla reported $6.7 billion in profit in those years.
Reposted by Mathieu Bourdenx
New in @naturecomms.bsky.social: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration www.nature.com/articles/s41...
Splicing accuracy varies across human introns, tissues, age and disease - Nature Communications
Inaccuracies in RNA splicing may play a significant role in aging and disease. Here, the authors present a comprehensive characterization of splicing accuracy across over 14,000 human samples, offerin...
www.nature.com
January 27, 2025 at 9:53 PM
New in @naturecomms.bsky.social: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration www.nature.com/articles/s41...
After spending 4 years in the USA for my postdoc and my daughter being born there, it always felt (and still feels like!) a second home. So it’s utterly sad to see what’s happening now. I stand with all my American friends! Resist ✊💪
January 25, 2025 at 6:48 PM
After spending 4 years in the USA for my postdoc and my daughter being born there, it always felt (and still feels like!) a second home. So it’s utterly sad to see what’s happening now. I stand with all my American friends! Resist ✊💪
Reposted by Mathieu Bourdenx
Notre programme est prêt.
Nous sommes au travail.
Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable.
www.leparisien.fr/elections/pr...
Nous sommes au travail.
Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable.
www.leparisien.fr/elections/pr...
Avec son nouveau programme, LFI fait un pas de plus vers la présidentielle
EXCLUSIF. Le mouvement de Jean-Luc Mélenchon a mis à jour son programme, l’Avenir en commun, et se prépare plus que jamais à une nouvelle él
www.leparisien.fr
January 25, 2025 at 10:23 AM
Notre programme est prêt.
Nous sommes au travail.
Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable.
www.leparisien.fr/elections/pr...
Nous sommes au travail.
Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable.
www.leparisien.fr/elections/pr...
That’s completely crazy ! And worrisome …
Parents matter - important study for modeling amyloid accumulation 🐭
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 9:02 PM
That’s completely crazy ! And worrisome …
Still waiting to see most UK and French universities to do the same …
January 13, 2025 at 10:22 PM
Still waiting to see most UK and French universities to do the same …
Reposted by Mathieu Bourdenx
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
January 3, 2025 at 7:25 PM
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlights⬇️
Reposted by Mathieu Bourdenx
🔥 chatomics! I regret not learning this well in college—and it changed how I approach bioinformatics today. Here’s my story and why you should avoid my mistake. 🧬
December 30, 2024 at 2:15 PM
🔥 chatomics! I regret not learning this well in college—and it changed how I approach bioinformatics today. Here’s my story and why you should avoid my mistake. 🧬
Paper alert from the Duff Lab 🚨🚨 My amazing colleagues showed that, in novel MAPTKI models, hyperphosphorylation (in absence of aggregation or even seeding) is sufficient to drive synapse loss and cognitive deficits. Huge implications for preclinical research and the way to therapies. Have a read!!
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience
Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...
www.nature.com
December 26, 2024 at 1:39 PM
Paper alert from the Duff Lab 🚨🚨 My amazing colleagues showed that, in novel MAPTKI models, hyperphosphorylation (in absence of aggregation or even seeding) is sufficient to drive synapse loss and cognitive deficits. Huge implications for preclinical research and the way to therapies. Have a read!!
Mindblowing paper creating spatial aging clocks 🤯🤯 ! Very neat use of spatial tx. Congrats to @brunetlab.bsky.social and all the authors
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 19, 2024 at 8:02 AM
Mindblowing paper creating spatial aging clocks 🤯🤯 ! Very neat use of spatial tx. Congrats to @brunetlab.bsky.social and all the authors
Help from the MRI community needed: I would like to plot simple regional expression of a protein in the Schaefer atlas. I have a vector of values per region for the atlas. I can’t seem to find my way around that simple thing. Any help will be appreciated!! @nilearn.bsky.social ?
November 29, 2024 at 7:38 PM
Help from the MRI community needed: I would like to plot simple regional expression of a protein in the Schaefer atlas. I have a vector of values per region for the atlas. I can’t seem to find my way around that simple thing. Any help will be appreciated!! @nilearn.bsky.social ?
It seems that a lot of people have transitioned from X to here, however I feel that institutes/centres/unis are still missing.
Did you try to convince yours to move? If so, how?
Did you try to convince yours to move? If so, how?
November 25, 2024 at 6:47 AM
It seems that a lot of people have transitioned from X to here, however I feel that institutes/centres/unis are still missing.
Did you try to convince yours to move? If so, how?
Did you try to convince yours to move? If so, how?
Reposted by Mathieu Bourdenx
New on BioRxiv: We report a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body.
Paper here: www.biorxiv.org/content/10.1...
1/
Paper here: www.biorxiv.org/content/10.1...
1/
November 20, 2024 at 2:55 PM
New on BioRxiv: We report a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body.
Paper here: www.biorxiv.org/content/10.1...
1/
Paper here: www.biorxiv.org/content/10.1...
1/
Reposted by Mathieu Bourdenx
November 22, 2024 at 4:23 AM