Max Korbmacher
@maxkorbmacher.bsky.social
Imaging neuroscientist.
Brain (bio)markers, big data, MRI, meta & open/better science. Views are my own.
Brain (bio)markers, big data, MRI, meta & open/better science. Views are my own.
Reposted by Max Korbmacher
Hello world! Follow this account to receive announcements, invitations for open peer review, and publications from Replication Research.
November 25, 2025 at 3:59 PM
Hello world! Follow this account to receive announcements, invitations for open peer review, and publications from Replication Research.
Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection
Marc-Andre Schulz, Nys Tjade Siegel, Kerstin Ritter
journals.plos.org/plosbiology/...
Marc-Andre Schulz, Nys Tjade Siegel, Kerstin Ritter
journals.plos.org/plosbiology/...
Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection
There is increasing interest in developing imaging-based models to characterize 'brain-age', but how accurate are these for predicting neurological disease? This study shows that simpler models, which...
journals.plos.org
November 19, 2025 at 9:55 PM
Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection
Marc-Andre Schulz, Nys Tjade Siegel, Kerstin Ritter
journals.plos.org/plosbiology/...
Marc-Andre Schulz, Nys Tjade Siegel, Kerstin Ritter
journals.plos.org/plosbiology/...
Reposted by Max Korbmacher
Is the “standard workflow” holding back fMRI analysis?
Mass-univariate analysis is still the bread-and-butter: intuitive, fast… and chronically overfitted. Add harsh multiple-comparison penalties, and we patch the workflow with statistical band-aids. No wonder the stringency debates never die.
Mass-univariate analysis is still the bread-and-butter: intuitive, fast… and chronically overfitted. Add harsh multiple-comparison penalties, and we patch the workflow with statistical band-aids. No wonder the stringency debates never die.
November 18, 2025 at 10:13 PM
Is the “standard workflow” holding back fMRI analysis?
Mass-univariate analysis is still the bread-and-butter: intuitive, fast… and chronically overfitted. Add harsh multiple-comparison penalties, and we patch the workflow with statistical band-aids. No wonder the stringency debates never die.
Mass-univariate analysis is still the bread-and-butter: intuitive, fast… and chronically overfitted. Add harsh multiple-comparison penalties, and we patch the workflow with statistical band-aids. No wonder the stringency debates never die.
Reposted by Max Korbmacher
Smeland, O.B., Kutrolli, G., Bahrami, S. et al. A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders. Nat Neurosci (2025). doi.org/10.1038/s415...
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders - Nature Neuroscience
Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations. The findings support a mo...
doi.org
November 14, 2025 at 7:07 AM
Smeland, O.B., Kutrolli, G., Bahrami, S. et al. A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders. Nat Neurosci (2025). doi.org/10.1038/s415...
Forskere skjuler nullfunn – koster samfunnet milliarder share.google/jgj4BlIEzVl4...
Forskere skjuler nullfunn – koster samfunnet milliarder
De fleste forskere sier de mener det er viktig å dele negative resultater, men langt færre gjør det i praksis. En ny undersøkelse fra Springer Nature viser at 98 prosent av forskerne er enige i at nul...
share.google
November 13, 2025 at 9:19 PM
Forskere skjuler nullfunn – koster samfunnet milliarder share.google/jgj4BlIEzVl4...
Reposted by Max Korbmacher
It's spooky season, so what better way to spend it than getting horrified by common statistical mistakes? A delightful dark read. It is great to follow the paper's development with reviewers' comments & authors' responses. By Tamar Makin from @plasticity-lab.bsky.social & Jean-Jacques Orban de Xivry
Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript
What can authors and reviewers do to keep common statistical mistakes out of the literature?
elifesciences.org
October 30, 2025 at 8:26 PM
It's spooky season, so what better way to spend it than getting horrified by common statistical mistakes? A delightful dark read. It is great to follow the paper's development with reviewers' comments & authors' responses. By Tamar Makin from @plasticity-lab.bsky.social & Jean-Jacques Orban de Xivry
Reposted by Max Korbmacher
New paper in Imaging Neuroscience by Adam M. Wright, Qiuting Wen, et al:
An fMRI approach to assess intracranial arterial-to-venous cardiac pulse delay in aging
doi.org/10.1162/IMAG...
An fMRI approach to assess intracranial arterial-to-venous cardiac pulse delay in aging
doi.org/10.1162/IMAG...
October 31, 2025 at 2:08 AM
New paper in Imaging Neuroscience by Adam M. Wright, Qiuting Wen, et al:
An fMRI approach to assess intracranial arterial-to-venous cardiac pulse delay in aging
doi.org/10.1162/IMAG...
An fMRI approach to assess intracranial arterial-to-venous cardiac pulse delay in aging
doi.org/10.1162/IMAG...
Reposted by Max Korbmacher
Sharing our new paper in Brain Communications ➡️ doi.org/10.1093/brai...
We show that structural connectivity, as measured by high-resolution diffusion-weighted MRI, improved the ability to predict age-related alterations in brain function and cognition, relative to standard spatial resolution.
We show that structural connectivity, as measured by high-resolution diffusion-weighted MRI, improved the ability to predict age-related alterations in brain function and cognition, relative to standard spatial resolution.
October 16, 2025 at 12:51 PM
Sharing our new paper in Brain Communications ➡️ doi.org/10.1093/brai...
We show that structural connectivity, as measured by high-resolution diffusion-weighted MRI, improved the ability to predict age-related alterations in brain function and cognition, relative to standard spatial resolution.
We show that structural connectivity, as measured by high-resolution diffusion-weighted MRI, improved the ability to predict age-related alterations in brain function and cognition, relative to standard spatial resolution.
Prado, P., Medel, V., Gonzalez-Gomez, R. et al. The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds. Sci Data 10, 889 (2023). doi.org/10.1038/s415...
The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds - Scientific Data
Scientific Data - The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds
doi.org
October 26, 2025 at 6:15 PM
Prado, P., Medel, V., Gonzalez-Gomez, R. et al. The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds. Sci Data 10, 889 (2023). doi.org/10.1038/s415...
Reposted by Max Korbmacher
12 waves!
Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12‐Wave Neuroimaging Study
Global and subcortical brain volumes demonstrate sex-specific increases (white matter, hippocampus, amygdala, and pallidum) and decreases (cortical grey matter, total brain volume, caudate, putamen, ...
onlinelibrary.wiley.com
October 14, 2025 at 10:00 PM
12 waves!
Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study
Human Brain Mapping | Neuroimaging Journal | Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Reposted by Max Korbmacher
Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder | Molecular Psychiatry www.nature.com/articles/s41...
Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder - Molecular Psychiatry
Molecular Psychiatry - Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder
www.nature.com
October 19, 2025 at 9:05 PM
Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder | Molecular Psychiatry www.nature.com/articles/s41...
Reposted by Max Korbmacher
New paper in Imaging Neuroscience by František Váša, Steven C.R. Williams, et al:
Ultra-low-field brain MRI morphometry: Test–retest reliability and correspondence to high-field MRI
doi.org/10.1162/IMAG...
Ultra-low-field brain MRI morphometry: Test–retest reliability and correspondence to high-field MRI
doi.org/10.1162/IMAG...
October 16, 2025 at 3:26 AM
New paper in Imaging Neuroscience by František Váša, Steven C.R. Williams, et al:
Ultra-low-field brain MRI morphometry: Test–retest reliability and correspondence to high-field MRI
doi.org/10.1162/IMAG...
Ultra-low-field brain MRI morphometry: Test–retest reliability and correspondence to high-field MRI
doi.org/10.1162/IMAG...
Reposted by Max Korbmacher
It’s not the thought that counts: Allostasis at the core of brain function
www.cell.com/neuron/fullt...
#neuroscience
www.cell.com/neuron/fullt...
#neuroscience
It’s not the thought that counts: Allostasis at the core of brain function
The authors review evidence that the primary function of the brain, supported by distributed
neural systems, is the predictive regulation of physiology (i.e., allostasis). An
example from Alzheimer’s ...
www.cell.com
October 18, 2025 at 1:54 PM
It’s not the thought that counts: Allostasis at the core of brain function
www.cell.com/neuron/fullt...
#neuroscience
www.cell.com/neuron/fullt...
#neuroscience
Multimodal predictors of disability progression and processing speed decline in relapsing–remitting multiple sclerosis
Breakdown below.
rdcu.be/eLiQ7
Breakdown below.
rdcu.be/eLiQ7
Multimodal predictors of disability progression and processing speed decline in relapsing–remitting multiple sclerosis
Scientific Reports - Multimodal predictors of disability progression and processing speed decline in relapsing–remitting multiple sclerosis
rdcu.be
October 17, 2025 at 7:27 AM
Multimodal predictors of disability progression and processing speed decline in relapsing–remitting multiple sclerosis
Breakdown below.
rdcu.be/eLiQ7
Breakdown below.
rdcu.be/eLiQ7
Reposted by Max Korbmacher
Another interesting paper from LifeBrain consortium suggesting that sex differences in healthy brain aging are unlikely to explain higher prevalence of Alzheimer’s disease in women www.pnas.org/doi/10.1073/...
Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s disease prevalence in women | PNAS
As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the
role of sex has become a key priority in AD research. However,...
www.pnas.org
October 14, 2025 at 3:20 AM
Another interesting paper from LifeBrain consortium suggesting that sex differences in healthy brain aging are unlikely to explain higher prevalence of Alzheimer’s disease in women www.pnas.org/doi/10.1073/...
Reposted by Max Korbmacher
New preprint from member of FORRT - How to Develop and Use Open Educational Resources 📣
In this chapter, we position Open Educational Resources (OERs) as not only cost-saving tools but as instruments of epistemic justice and inclusion.
📃 osf.io/preprints/ed...
🧵👇
In this chapter, we position Open Educational Resources (OERs) as not only cost-saving tools but as instruments of epistemic justice and inclusion.
📃 osf.io/preprints/ed...
🧵👇
OSF
osf.io
October 10, 2025 at 8:34 AM
New preprint from member of FORRT - How to Develop and Use Open Educational Resources 📣
In this chapter, we position Open Educational Resources (OERs) as not only cost-saving tools but as instruments of epistemic justice and inclusion.
📃 osf.io/preprints/ed...
🧵👇
In this chapter, we position Open Educational Resources (OERs) as not only cost-saving tools but as instruments of epistemic justice and inclusion.
📃 osf.io/preprints/ed...
🧵👇
OPEN FOR SUBMISSIONS! NOW!
ReplicationResearch.org is now open for submissions!
Submit replications and reproductions from many different fields, as well as conceptual contributions. With diamond OA, open and citable peer review reports, and reproducibility checks, we push the boundaries of open and fair publishing.
Submit replications and reproductions from many different fields, as well as conceptual contributions. With diamond OA, open and citable peer review reports, and reproducibility checks, we push the boundaries of open and fair publishing.
October 10, 2025 at 6:24 AM
OPEN FOR SUBMISSIONS! NOW!
Prolonged White Matter Remodeling Trajectories Predict Cognitive and Emotional Recovery After Mild Traumatic Brain Injury, 03 October 2025 (preprint)
Aishwarya Rajesh, Timothy Laumann, Qing Wang et al.
doi.org/10.21203/rs....
Aishwarya Rajesh, Timothy Laumann, Qing Wang et al.
doi.org/10.21203/rs....
https://doi.org/10.21203/rs.3.rs-7682138/v1]
October 8, 2025 at 7:24 PM
Prolonged White Matter Remodeling Trajectories Predict Cognitive and Emotional Recovery After Mild Traumatic Brain Injury, 03 October 2025 (preprint)
Aishwarya Rajesh, Timothy Laumann, Qing Wang et al.
doi.org/10.21203/rs....
Aishwarya Rajesh, Timothy Laumann, Qing Wang et al.
doi.org/10.21203/rs....
ComBatLS: A Location- and Scale-Preserving Method for Multi-Site Image Harmonization
doi.org/10.1002/hbm....
doi.org/10.1002/hbm....
ComBatLS: A Location‐ and Scale‐Preserving Method for Multi‐Site Image Harmonization
We introduce ComBatLS, a new harmonization method that preserves the effects of biological covariates like sex and age on brain feature distributions' variances or scale parameters. We show that ComB...
doi.org
October 6, 2025 at 11:18 PM
ComBatLS: A Location- and Scale-Preserving Method for Multi-Site Image Harmonization
doi.org/10.1002/hbm....
doi.org/10.1002/hbm....
Haukvik, U.K., Wolfers, T., Tesli, N. et al. Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy. Transl Psychiatry 15, 118 (2025). doi.org/10.1038/s413...
Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy - Translational Psychiatry
Translational Psychiatry - Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy
doi.org
October 4, 2025 at 12:08 PM
Haukvik, U.K., Wolfers, T., Tesli, N. et al. Individual-level deviations from normative brain morphology in violence, psychosis, and psychopathy. Transl Psychiatry 15, 118 (2025). doi.org/10.1038/s413...
Judged by your neighbors: A novel framework for personalized assessment of brain structural aging effects in diverse populations
Ramona Leenings et al doi.org/10.1101/2024...
Ramona Leenings et al doi.org/10.1101/2024...
Judged by your neighbors: A novel framework for personalized assessment of brain structural aging effects in diverse populations
Despite their promise, current neuroimaging biomarkers often fail to capture the full spectrum of inter-individual variability in brain structure and aging effects. This limits their ability to detect...
doi.org
October 1, 2025 at 9:33 PM
Judged by your neighbors: A novel framework for personalized assessment of brain structural aging effects in diverse populations
Ramona Leenings et al doi.org/10.1101/2024...
Ramona Leenings et al doi.org/10.1101/2024...
Reposted by Max Korbmacher
Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia www.nature.com/articles/s41...
Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia - Nature Communications
Individuals with schizophrenia show reduced structural similarity in temporal, cingulate, and insular lobes, especially those with worse cognition and symptoms, affecting late maturing association areas with low metabolism and high neurotransmission.
www.nature.com
October 1, 2025 at 12:58 PM
Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia www.nature.com/articles/s41...
Reposted by Max Korbmacher
New paper in Imaging Neuroscience by Peder A.G. Lillebostad, Arvid Lundervold, et al:
Deep-learning segmentation of the substantia nigra from multiparametric MRI: Application to Parkinson’s disease
doi.org/10.1162/IMAG...
Deep-learning segmentation of the substantia nigra from multiparametric MRI: Application to Parkinson’s disease
doi.org/10.1162/IMAG...
September 29, 2025 at 8:51 PM
New paper in Imaging Neuroscience by Peder A.G. Lillebostad, Arvid Lundervold, et al:
Deep-learning segmentation of the substantia nigra from multiparametric MRI: Application to Parkinson’s disease
doi.org/10.1162/IMAG...
Deep-learning segmentation of the substantia nigra from multiparametric MRI: Application to Parkinson’s disease
doi.org/10.1162/IMAG...