Matt Foster
@mattwfoster.bsky.social
Proteomics, humor, bbq, gravel riding, hiking, violin, gardening. Durham, NC
Focused (now) on analyzing whole 🩸 in sepsis. Pulmonary, Allergy and Critical Care Medicine, and Proteomics and Metabolomics Core Facility, Duke University
Focused (now) on analyzing whole 🩸 in sepsis. Pulmonary, Allergy and Critical Care Medicine, and Proteomics and Metabolomics Core Facility, Duke University
Q-values of 0.00 are "probably the best ever".....
November 25, 2025 at 2:15 AM
Q-values of 0.00 are "probably the best ever".....
Proteomics core was about 6 years faster to return data….https://www.nature.com/articles/s41598-019-40546-1
Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging - Scientific Reports
Scientific Reports - Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging
www.nature.com
November 15, 2025 at 1:53 PM
Proteomics core was about 6 years faster to return data….https://www.nature.com/articles/s41598-019-40546-1
Trade-ins probably factor as well.
November 10, 2025 at 5:31 PM
Trade-ins probably factor as well.
We have a chase in the middle of the lab styled after the pictured Waters’ Wilmslow facility. Didn’t have quite enough HVAC capacity at install. If you want to hide pumps put them in a space where you can stand up rather than have to crawl around on the floor to service.
November 8, 2025 at 9:48 PM
We have a chase in the middle of the lab styled after the pictured Waters’ Wilmslow facility. Didn’t have quite enough HVAC capacity at install. If you want to hide pumps put them in a space where you can stand up rather than have to crawl around on the floor to service.
November 1, 2025 at 5:26 PM
Well I do applaud the fact that you are analyzing sub nL of plasma :)
October 7, 2025 at 2:33 PM
Well I do applaud the fact that you are analyzing sub nL of plasma :)
But is data better on an Ultra at low levels for all sample types versus a less sensitive instrument at higher loads?
October 7, 2025 at 2:25 PM
But is data better on an Ultra at low levels for all sample types versus a less sensitive instrument at higher loads?
I think the sds page was used for visualization only. Many more fluids to go, including numerous airway (bronchoalveolaer and nasal lavage, sputum, exhaled condensates) and sex-specific (breast milk, cord blood, amniotic fluid) to name a few.
October 2, 2025 at 5:28 PM
I think the sds page was used for visualization only. Many more fluids to go, including numerous airway (bronchoalveolaer and nasal lavage, sputum, exhaled condensates) and sex-specific (breast milk, cord blood, amniotic fluid) to name a few.
Nice work. Thoughts on reference pools for whole blood proteomics? Limited to mixing blood from compatible donors, which we have done on a small scale.
September 24, 2025 at 4:41 PM
Nice work. Thoughts on reference pools for whole blood proteomics? Limited to mixing blood from compatible donors, which we have done on a small scale.
We just got a box of those lab coats. So stylish with the cuffs.
September 20, 2025 at 7:17 PM
We just got a box of those lab coats. So stylish with the cuffs.
All for DIY but then they use commercial ZipTips or HLB for the cleanup 🤔
September 18, 2025 at 4:56 PM
All for DIY but then they use commercial ZipTips or HLB for the cleanup 🤔
Reposted by Matt Foster
You can make a multi-course meal with NIST standards. Quenelles de SRM 1946 anyone? Mousse au SRM 2384? Finishing with an SRM 1196, if you're so inclined. @benneely.com can probably tell you how to best prepare the SRM 1945.
September 13, 2025 at 2:18 PM
You can make a multi-course meal with NIST standards. Quenelles de SRM 1946 anyone? Mousse au SRM 2384? Finishing with an SRM 1196, if you're so inclined. @benneely.com can probably tell you how to best prepare the SRM 1945.
I misread those dates 🤣
September 11, 2025 at 5:31 PM
I misread those dates 🤣
First decision is desk reject or not.
September 11, 2025 at 5:30 PM
First decision is desk reject or not.
Huh? If you ingest it but otherwise…..
September 10, 2025 at 9:51 PM
Huh? If you ingest it but otherwise…..
An Evosep will give you most of the benefits of micro or analytical flow in terms of throughput, minimizing carryover and robustness. Except for low input, what are the benefits of nanoLC?
September 7, 2025 at 5:28 PM
An Evosep will give you most of the benefits of micro or analytical flow in terms of throughput, minimizing carryover and robustness. Except for low input, what are the benefits of nanoLC?
Still doing 1 mm (100 uL/min) for some neat biofluids where it's easy to digest a ton but I tend agree that input requirements can be limiting. The sweet spot for these systems is really 30+ micrograms on column IMO....
September 7, 2025 at 5:28 PM
Still doing 1 mm (100 uL/min) for some neat biofluids where it's easy to digest a ton but I tend agree that input requirements can be limiting. The sweet spot for these systems is really 30+ micrograms on column IMO....
I feel like we just used the keyboard for most games on the Apple 2 and Atari 800. karateka, joust, ….
September 6, 2025 at 11:39 PM
I feel like we just used the keyboard for most games on the Apple 2 and Atari 800. karateka, joust, ….
Also there is a direct connection to QuantumSi in this referenced work. The single molecule counting idea has been around a long time.
August 30, 2025 at 10:42 PM
Also there is a direct connection to QuantumSi in this referenced work. The single molecule counting idea has been around a long time.