@matteomazzocca.bsky.social
Postdoc @andersshansen.bsky.social Lab @ MIT | PhD @davidemazza.bsky.social Lab @ Vita-Salute San Raffaele University | 3D genome, TFs, gene regulation
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This was a true team effort with @domenicnarducci.bsky.social, Simon Grosse-Holz,
@jessematthias.bsky.social & @andersshansen.bsky.social. I’m grateful and proud to have worked together. Huge thanks to AICF for their fellowship support. Check out the preprint:
www.biorxiv.org/content/10.1...
This was a true team effort with @domenicnarducci.bsky.social, Simon Grosse-Holz,
@jessematthias.bsky.social & @andersshansen.bsky.social. I’m grateful and proud to have worked together. Huge thanks to AICF for their fellowship support. Check out the preprint:
www.biorxiv.org/content/10.1...
Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude
Chromatin dynamics control the timescales of essential biological processes including DNA damage repair and activation of gene promoters by distal enhancers. Prior chromatin dynamics studies have repo...
www.biorxiv.org
May 14, 2025 at 5:58 PM
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This was a true team effort with @domenicnarducci.bsky.social, Simon Grosse-Holz,
@jessematthias.bsky.social & @andersshansen.bsky.social. I’m grateful and proud to have worked together. Huge thanks to AICF for their fellowship support. Check out the preprint:
www.biorxiv.org/content/10.1...
This was a true team effort with @domenicnarducci.bsky.social, Simon Grosse-Holz,
@jessematthias.bsky.social & @andersshansen.bsky.social. I’m grateful and proud to have worked together. Huge thanks to AICF for their fellowship support. Check out the preprint:
www.biorxiv.org/content/10.1...
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However, as distance increases search times become progressively more challenging. At ~1µm (1-3 Mb), EP can take ~5-24 h to randomly find each other – potentially too long for a cell cycle → distant EP need help (e.g. loop extrusion)
However, as distance increases search times become progressively more challenging. At ~1µm (1-3 Mb), EP can take ~5-24 h to randomly find each other – potentially too long for a cell cycle → distant EP need help (e.g. loop extrusion)
May 14, 2025 at 5:58 PM
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However, as distance increases search times become progressively more challenging. At ~1µm (1-3 Mb), EP can take ~5-24 h to randomly find each other – potentially too long for a cell cycle → distant EP need help (e.g. loop extrusion)
However, as distance increases search times become progressively more challenging. At ~1µm (1-3 Mb), EP can take ~5-24 h to randomly find each other – potentially too long for a cell cycle → distant EP need help (e.g. loop extrusion)
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We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
May 14, 2025 at 5:58 PM
3/
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
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Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
May 14, 2025 at 5:58 PM
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Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions