@matteomazzocca.bsky.social
Postdoc @andersshansen.bsky.social Lab @ MIT | PhD @davidemazza.bsky.social Lab @ Vita-Salute San Raffaele University | 3D genome, TFs, gene regulation
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We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
May 14, 2025 at 5:58 PM
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We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
We ran simulations to estimate EP search times based on 1) measured subdiffusion, 2) physical/genomic distance. Within 300nm (~<200 kb), a gene can find 1000s of enhancers in minutes. Such encounters can’t be selective → EP selectivity needs other mechanisms, e.g. biochemical
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Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
May 14, 2025 at 5:58 PM
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Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
Such fast and long chromatin tracking is key to understanding how distal genomic elements (e.g. enhancers and promoters – EP) find each other. We found chromatin is highly subdiffusive (α ~ 0.3) -> loci are great at exploring the neighborhoods but rarely reach distant regions
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Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
May 14, 2025 at 5:58 PM
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Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)