End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon.
🌐 evedesign.bio

Below we show GPU-accelerated Foldseek, searching 128 structures against AFDB50 (54 million structures). On 128 CPU cores this takes ~120 seconds, whereas a single GPU completes it in ~25 seconds. 2/n

Folddisco webserver result view update:
- Added description texts for AFDB
- Integrated TaxoView taxonomy visualization & filter by @sunjaelee.bsky.social
- Inter-residue distance clustering by DBSCAN to explore motif diversity.
🌐 search.foldseek.com/folddisco
📄 www.biorxiv.org/content/10.1...

We provide a user-friendly Folddisco webserver, enabling instant structural motif searches in PDB, AFDB-Proteomes, AFDB50 (available later today), and ESMatlas (ESM30). Explore it here: search.foldseek.com/folddisco 8/9

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco

We've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments.
🌐 afesm.foldseek.com
Read more about the work in the skeetorial
🦋 bsky.app/profile/mart...
or our preprint
📄 www.biorxiv.org/content/10.1...

Explore AFESM with our website! You can search your favorite proteins from ESMatlas or AFDB using their identifiers. It's still a work in progress, with many exciting features on the way! 7/n
🌐 afesm.foldseek.com