Mariska Leeflang
@mariskaleeflang.bsky.social
Professor in Clinical epidemiology, with a focus on medical tests and diagnostic test accuracy #SystematicReviews. Interested in #reproducibility of science. osiris4r.eu
#AcademicSky #EpiSky
#AcademicSky #EpiSky
Reposted by Mariska Leeflang
It's really not a surprise. I've spent the last 5 years explaining to researchers why samples collected over 2 consecutive EU projects and extracted using wildly different protocols are in no way comparable.
Too many labs think omics-related research is "just sequencing innit".
Too many labs think omics-related research is "just sequencing innit".
November 16, 2025 at 12:54 PM
It's really not a surprise. I've spent the last 5 years explaining to researchers why samples collected over 2 consecutive EU projects and extracted using wildly different protocols are in no way comparable.
Too many labs think omics-related research is "just sequencing innit".
Too many labs think omics-related research is "just sequencing innit".
Reposted by Mariska Leeflang
My #rstats cheat code for today is the binom.confint function in the binom package that will spit out *12* different ways of calculating a CI for a proportion.
Also, this is why you use R for statistics...
(and of course the correct CI method is bayes 😎)
Also, this is why you use R for statistics...
(and of course the correct CI method is bayes 😎)
November 16, 2025 at 2:52 AM
My #rstats cheat code for today is the binom.confint function in the binom package that will spit out *12* different ways of calculating a CI for a proportion.
Also, this is why you use R for statistics...
(and of course the correct CI method is bayes 😎)
Also, this is why you use R for statistics...
(and of course the correct CI method is bayes 😎)
Reposted by Mariska Leeflang
Ready to level up your research game? Join us for our next session on transparent literature reviews! Come along in person or tune in online. All the details are below!
November 14, 2025 at 3:34 PM
Ready to level up your research game? Join us for our next session on transparent literature reviews! Come along in person or tune in online. All the details are below!
Reposted by Mariska Leeflang
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 13, 2025 at 4:00 PM
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
www.nrc.nl/nieuws/2025/...
Interessante actie, maar is dit onderzoek of preventie (de tekst is wat ambigu)? Als je van alle acute problemen gaat tellen hoeveel mensen vapen, ga je in elk geval geen causaal verband aan kunnen tonen. Of mis ik iets?
Interessante actie, maar is dit onderzoek of preventie (de tekst is wat ambigu)? Als je van alle acute problemen gaat tellen hoeveel mensen vapen, ga je in elk geval geen causaal verband aan kunnen tonen. Of mis ik iets?
Landelijke studie op de SEH moet verband tussen roken en acute klachten aantonen. ‘Pas als je het in cijfers ziet, dringt de schade van nicotine door’
Rookwaar: Tijdens een onderzoeksdag op de SEH van Nederlandse ziekenhuizen wordt onderzocht of acute klachten verband houden met nicotinegebruik. Artsen maken zich onder meer ernstig zorgen over jonge...
www.nrc.nl
November 14, 2025 at 6:44 AM
www.nrc.nl/nieuws/2025/...
Interessante actie, maar is dit onderzoek of preventie (de tekst is wat ambigu)? Als je van alle acute problemen gaat tellen hoeveel mensen vapen, ga je in elk geval geen causaal verband aan kunnen tonen. Of mis ik iets?
Interessante actie, maar is dit onderzoek of preventie (de tekst is wat ambigu)? Als je van alle acute problemen gaat tellen hoeveel mensen vapen, ga je in elk geval geen causaal verband aan kunnen tonen. Of mis ik iets?
"Funders hold the cards"
Fundamentally, what we need is leadership. But we break with the chorus of most #OpenScience initiatives here and emphasize very strongly that this leadership must come from funders and institutions.
We researchers can support the battle, but we cannot lead the charge. Funders hold the cards.
6/n
We researchers can support the battle, but we cannot lead the charge. Funders hold the cards.
6/n
November 13, 2025 at 6:56 AM
"Funders hold the cards"
Reposted by Mariska Leeflang
I'm in Sydney until December 15th.
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 12, 2025 at 3:42 AM
I'm in Sydney until December 15th.
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
If any tweeps (blueskyers?) are around lets get lunch or coffee!
Also ... if you allow random strangers to join your D&D* group for a few weeks ... pleeeeeeease let me know :)))
___
* or whatever pen & paper y'all are up to
Reposted by Mariska Leeflang
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests
Essential first steps in performing a health technology assessment (HTA) for a diagnostic
test include: consideration of the clinical pathway in which the test will be used,
specifying the clinical cl...
www.jclinepi.com
November 10, 2025 at 3:50 PM
Methodological review reveals essential gaps and inconsistencies in clinical claims, effects and outcomes in HTA reviews of diagnostic tests - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Mariska Leeflang
Voor mensen die mijn webshop willen bekijken, het is niks bijzonders. Er staat 1 product in maar wel met 6 verschillende betaalmethoden. En bestellen kan nog steeds gewoon hier op Bluesky voornamelijk tot ik alles uitgevogeld heb.
Www.hetwonderkabinet.nl
Www.hetwonderkabinet.nl
Het Wonderkabinet
De Atelier en Wunderkammer van Hester Loeff. Met handgemaakte kabinetjes en schelptekeningen maar ook naturalia zoals fossielen en schelpen.
Www.hetwonderkabinet.nl
November 8, 2025 at 1:24 PM
Voor mensen die mijn webshop willen bekijken, het is niks bijzonders. Er staat 1 product in maar wel met 6 verschillende betaalmethoden. En bestellen kan nog steeds gewoon hier op Bluesky voornamelijk tot ik alles uitgevogeld heb.
Www.hetwonderkabinet.nl
Www.hetwonderkabinet.nl
Reposted by Mariska Leeflang
De zorg doet domme dingen met slimme technologie. Terwijl het zo eenvoudig beter kan. www.artsenauto.nl/domme-dingen...
Domme dingen doen met slimme technologie - Arts en Auto - Frank van Wijck
Wat speelt in de zorg? Frank van Wijck schrijft op vrijdag over actuele uitspraken en ontwikkelingen. Deze keer: aanmeldzuilen.
www.artsenauto.nl
November 7, 2025 at 7:29 AM
De zorg doet domme dingen met slimme technologie. Terwijl het zo eenvoudig beter kan. www.artsenauto.nl/domme-dingen...
Reposted by Mariska Leeflang
Winkeldraadje van Het Wonderkabinet. Wat heb ik dit najaar te koop? Ik post alles hieronder zolang de webshop nog niet staat. Niet alles is op voorraad maar het meeste kan in opdracht (zolang de voorraad strekt en ik nog tijd heb). Graag een DM als je iets ziet en repost is lief!
November 3, 2025 at 6:59 PM
Winkeldraadje van Het Wonderkabinet. Wat heb ik dit najaar te koop? Ik post alles hieronder zolang de webshop nog niet staat. Niet alles is op voorraad maar het meeste kan in opdracht (zolang de voorraad strekt en ik nog tijd heb). Graag een DM als je iets ziet en repost is lief!
Reposted by Mariska Leeflang
‘Study after study shows that students want to develop these critical thinking skills, are not lazy, and large numbers of them would be in favor of banning ChatGPT and similar tools in universities’, says @olivia.science www.ru.nl/en/research/...
‘Opposing the inevitability of AI at universities is possible and necessary’ | Radboud University
Since the widespread release of ChatGPT in December of 2022, AI has taken over much of the world by storm – including academia. Most of this happened with very little pushback, despite a myriad of iss...
www.ru.nl
November 1, 2025 at 10:26 PM
‘Study after study shows that students want to develop these critical thinking skills, are not lazy, and large numbers of them would be in favor of banning ChatGPT and similar tools in universities’, says @olivia.science www.ru.nl/en/research/...
Reposted by Mariska Leeflang
Ik heb nog nieuwe groene in de maak. Ik maak ze nu met ontspiegeld Clarity glas, dat is een stuk mooier (zie foto) maar ook de prijs is anders. Ze komen dan inclusief (aangetekend) verzenden op €530,-
Als je er nog een wil reserveren (of een andere kleur) dan kun je een DM sturen.
Repost is lief
Als je er nog een wil reserveren (of een andere kleur) dan kun je een DM sturen.
Repost is lief
November 1, 2025 at 7:41 AM
Ik heb nog nieuwe groene in de maak. Ik maak ze nu met ontspiegeld Clarity glas, dat is een stuk mooier (zie foto) maar ook de prijs is anders. Ze komen dan inclusief (aangetekend) verzenden op €530,-
Als je er nog een wil reserveren (of een andere kleur) dan kun je een DM sturen.
Repost is lief
Als je er nog een wil reserveren (of een andere kleur) dan kun je een DM sturen.
Repost is lief
Reposted by Mariska Leeflang
#EpiSky, don't miss out on the opportunity to listen to interesting & entertaining keynote lectures by @mariskaleeflang.bsky.social (@amsterdamumc.bsky.social) & #OliverKuss (@ddzdiabetes.bsky.social, @hhu.de)! It's free & there will be food!
🍂 Herbstworkshop in Bielefeld 🍂
Am 20.–21.11.2025 treffen sich Expertinnen und Experte aus Statistik, Epidemiologie und klinischer Forschung zum interdisziplinären Austausch unter dem Motto:
From Evidence Synthesis to Precision Medicine
🔗 Registrierung: lnkd.in/eBU6iSQ2
ℹ️ Infos: lnkd.in/ezpD_kiV
Am 20.–21.11.2025 treffen sich Expertinnen und Experte aus Statistik, Epidemiologie und klinischer Forschung zum interdisziplinären Austausch unter dem Motto:
From Evidence Synthesis to Precision Medicine
🔗 Registrierung: lnkd.in/eBU6iSQ2
ℹ️ Infos: lnkd.in/ezpD_kiV
October 30, 2025 at 4:45 PM
#EpiSky, don't miss out on the opportunity to listen to interesting & entertaining keynote lectures by @mariskaleeflang.bsky.social (@amsterdamumc.bsky.social) & #OliverKuss (@ddzdiabetes.bsky.social, @hhu.de)! It's free & there will be food!
Reposted by Mariska Leeflang
Radboud researchers René Aquarius @deadneanderthals.bsky.social and Kim Wever were about to embark on a literature review project when they noticed several odd things that made them stop in their tracks, then change the course of their study entirely.
October 30, 2025 at 6:48 PM
Radboud researchers René Aquarius @deadneanderthals.bsky.social and Kim Wever were about to embark on a literature review project when they noticed several odd things that made them stop in their tracks, then change the course of their study entirely.
For all those among us who like their multivariable analyses in what these authors call "factors associated with" studies.
We wrote an article explaining why you shouldn't put several variables into a regression model and report which are statistically significant - even as exploratory research. bmjmedicine.bmj.com/content/4/1/.... How did we do?
October 27, 2025 at 8:04 PM
For all those among us who like their multivariable analyses in what these authors call "factors associated with" studies.
Reposted by Mariska Leeflang
MetaROR, a platform for reviews of research on research, is a success! We have published 24 sets of reviews and have 16 submissions in process. MetaROR now has 9 partners - these are journals that agree to use our reviews when authors submit to them. metaror.org #metascience #openaccess
Home - MetaROR
MetaResearch Open Review
MetaResearch Open Review MetaResearch Open Review
A new platform designed to transform how we review and share metaresearch
A new platform designed to transform
metaror.org
October 26, 2025 at 10:33 PM
MetaROR, a platform for reviews of research on research, is a success! We have published 24 sets of reviews and have 16 submissions in process. MetaROR now has 9 partners - these are journals that agree to use our reviews when authors submit to them. metaror.org #metascience #openaccess
Reposted by Mariska Leeflang
this thread nicely describes the epistemology of a decent portion of modern meta-science, and i think also explains why it lost steam
Simonsohn has now posted a blog response to our recent paper about the poor statistical properties of the P curve. @clintin.bsky.social and I are finishing up a less-technical paper that will serve as a response. But I wanted to address a meta-issue *around* this that may clarify some things. 1/x
Would p-curve work if you dropped a piano on it?
datacolada.org/129
datacolada.org/129
October 24, 2025 at 5:29 AM
this thread nicely describes the epistemology of a decent portion of modern meta-science, and i think also explains why it lost steam
Reposted by Mariska Leeflang
Iemand in (de buurt) van Utrecht die wil en kan?
October 16, 2025 at 2:08 PM
Iemand in (de buurt) van Utrecht die wil en kan?
Reposted by Mariska Leeflang
Zoek de verschillen
October 16, 2025 at 2:13 PM
Zoek de verschillen
Reposted by Mariska Leeflang
Energy requirements for AI mean that the only way for the bubble not to burst would require companies to multiply their carbon footprint to an unimaginable degree. Right now, while AI is barely functional and mostly a novelty for the lazy, it requires so much energy that data centers rival cities.
October 9, 2025 at 11:11 AM
Energy requirements for AI mean that the only way for the bubble not to burst would require companies to multiply their carbon footprint to an unimaginable degree. Right now, while AI is barely functional and mostly a novelty for the lazy, it requires so much energy that data centers rival cities.
Reposted by Mariska Leeflang
⭐️Nominate an Impactful Dataset
@agu.org invites you to nominate an impactful dataset!
📊Submissions will be considered for inclusion in an upcoming featured commentary published in AGU Advances.
Submit nominations by 20 October.
docs.google.com/forms/d/e/1F...
@agubiogeosciences.bsky.social
@agu.org invites you to nominate an impactful dataset!
📊Submissions will be considered for inclusion in an upcoming featured commentary published in AGU Advances.
Submit nominations by 20 October.
docs.google.com/forms/d/e/1F...
@agubiogeosciences.bsky.social
Nominate an Impactful Dataset
You are invited to nominate a dataset to be included in a commentary about the impact of Earth, space, and environmental data using the dimensions of people, planet, and prosperity. Selected submitter...
docs.google.com
October 5, 2025 at 6:32 PM
⭐️Nominate an Impactful Dataset
@agu.org invites you to nominate an impactful dataset!
📊Submissions will be considered for inclusion in an upcoming featured commentary published in AGU Advances.
Submit nominations by 20 October.
docs.google.com/forms/d/e/1F...
@agubiogeosciences.bsky.social
@agu.org invites you to nominate an impactful dataset!
📊Submissions will be considered for inclusion in an upcoming featured commentary published in AGU Advances.
Submit nominations by 20 October.
docs.google.com/forms/d/e/1F...
@agubiogeosciences.bsky.social
Reposted by Mariska Leeflang
I have just left a lengthy Pubpeer comment on the autism/Tylenol study being cited by the Trump administration. There appear to be a number of fairly straightforward errors in the paper.
pubpeer.com/publications...
pubpeer.com/publications...
PubPeer - Evaluation of the evidence on acetaminophen use and neurodev...
There are comments on PubPeer for publication: Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology (2025)
pubpeer.com
October 1, 2025 at 5:03 AM
I have just left a lengthy Pubpeer comment on the autism/Tylenol study being cited by the Trump administration. There appear to be a number of fairly straightforward errors in the paper.
pubpeer.com/publications...
pubpeer.com/publications...
Great idea!
@ingestegeman.bsky.social
@ingestegeman.bsky.social
AI peer review needs to be peer-reviewed: Can AI match the insights of human referees? We don’t know. So before implementation, let’s run the experiment www.timeshighereducation.com/opinion/ai-p...
AI peer review needs to be peer-reviewed
Can AI match the insights of human referees? We don’t know. So before implementation, let’s run the experiment, says Sheldon H. Jacobson
buff.ly
September 24, 2025 at 4:17 PM
Great idea!
@ingestegeman.bsky.social
@ingestegeman.bsky.social
Reposted by Mariska Leeflang
"De wetenschappelijke integriteit staat op het spel nu universiteiten [AI] zonder kritische bezinning omarmen. Dat is de waarschuwing van een internationale groep van achttien wetenschappers, onder leiding van onderzoekers van de Radboud Universiteit.”
www.scienceguide.nl/2025/09/ai-s... 1/🧵
www.scienceguide.nl/2025/09/ai-s... 1/🧵
AI schaadt wetenschappelijke integriteit en vergroot kansenongelijkheid, waarschuwen wetenschappers - ScienceGuide
De wetenschappelijke integriteit staat op het spel nu universiteiten kunstmatige intelligentie zonder kritische bezinning omarmen. Dat is de waarschuwing van een internationale groep van zestien weten...
www.scienceguide.nl
September 18, 2025 at 9:02 PM
"De wetenschappelijke integriteit staat op het spel nu universiteiten [AI] zonder kritische bezinning omarmen. Dat is de waarschuwing van een internationale groep van achttien wetenschappers, onder leiding van onderzoekers van de Radboud Universiteit.”
www.scienceguide.nl/2025/09/ai-s... 1/🧵
www.scienceguide.nl/2025/09/ai-s... 1/🧵